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Диагностические возможности применения микро‑РНК при трансплантации почки

https://doi.org/10.15825/1995-1191-2018-3-87-94

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Аннотация

Аллогенная трансплантация почки является оптимальным подходом для лечения пациентов с терминальной стадией хронической болезни почек. При этом посттрансплантационный  мониторинг и оптимизация иммуносупрессивной терапии с помощью ранних неинвазивных  молекулярно-биологических маркеров может значительно улучшить долгосрочный результат  трансплантационного лечения. В качестве маркеров повреждения почечного трансплантата  предлагается использовать микро-РНК, играющие фундаментальную роль в регуляции активности  различных генов. Уровень экспрессии микро-РНК в различных тканях может коррелировать с  определенными патологическими состояниями. В настоящем обзоре рассмотрены литературные  данные, касающиеся изучения перспектив применения микро-РНК в качестве биомаркеров течения посттрансплантационного периода у реципиентов почечного трансплантата.

Об авторах

И. А. Пирожков
ГБУ «Санкт-Петербургский научно-исследовательский институт скорой помощи имени И.И. Джанелидзе»
Россия

Адрес: 192242, Санкт-Петербург, ул. Будапештская, д. 3, лит. А. Тел. (911) 709-90-14



М. Е. Малышев
ГБУ «Санкт-Петербургский научно-исследовательский институт скорой помощи имени И.И. Джанелидзе»
Россия


О. Н. Резник
ГБУ «Санкт-Петербургский научно-исследовательский институт скорой помощи имени И.И. Джанелидзе»
Россия


В. А. Мануковский
ГБУ «Санкт-Петербургский научно-исследовательский институт скорой помощи имени И.И. Джанелидзе»
Россия


А. Е. Скворцов
ГБУ «Санкт-Петербургский научно-исследовательский институт скорой помощи имени И.И. Джанелидзе»
Россия


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Для цитирования:


Пирожков И.А., Малышев М.Е., Резник О.Н., Мануковский В.А., Скворцов А.Е. Диагностические возможности применения микро‑РНК при трансплантации почки. Вестник трансплантологии и искусственных органов. 2018;20(3):87-94. https://doi.org/10.15825/1995-1191-2018-3-87-94

For citation:


Pirozhkov I.A., Malyshev M.E., Reznik O.N., Manukovsky V.A., Skvortsov A.E. Diagnostic possibilities of using micro-RNA for kidney transplantation. Russian Journal of Transplantology and Artificial Organs. 2018;20(3):87-94. (In Russ.) https://doi.org/10.15825/1995-1191-2018-3-87-94

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ISSN 1995-1191 (Print)
ISSN 2412-6160 (Online)