References

vtio

Вестник трансплантологии и искусственных органов

Russian Journal of Transplantology and Artificial Organs

1995-1191

Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation

10.15825/1995-1191-2018-3-87-94

vtio-917

Research Article

Обзор литературы

Literature Reviews

Диагностические возможности применения микро‑РНК при трансплантации почки

Diagnostic possibilities of using micro-RNA for kidney transplantation

Пирожков

И. А.

Pirozhkov

I. A.

Адрес: 192242, Санкт-Петербург, ул. Будапештская, д. 3, лит. А. Тел. (911) 709-90-14

Address: 3, Budapeshtskaya str., St. Petersburg, 192242, Russian Federation. Теl. (911) 709-90-14

ipir@mail.ru

Малышев

М. Е.

Malyshev

M. E.

Резник

О. Н.

Reznik

O. N.

Мануковский

В. А.

Manukovsky

V. A.

Скворцов

А. Е.

Skvortsov

A. E.

ГБУ «Санкт-Петербургский научно-исследовательский институт скорой помощи имени И.И. Джанелидзе»РоссияSaint-Petersburg I.I. Dzhanelidze State Research Institute of Emergency MedicineRussian Federation

2018

17092018

2038794

2018

Пирожков И.А., Малышев М.Е., Резник О.Н., Мануковский В.А., Скворцов А.Е.

Pirozhkov I.A., Malyshev M.E., Reznik O.N., Manukovsky V.A., Skvortsov A.E.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.transpl.ru/vtio/article/view/917

Аллогенная трансплантация почки является оптимальным подходом для лечения пациентов с терминальной стадией хронической болезни почек. При этом посттрансплантационный мониторинг и оптимизация иммуносупрессивной терапии с помощью ранних неинвазивных молекулярно-биологических маркеров может значительно улучшить долгосрочный результат трансплантационного лечения. В качестве маркеров повреждения почечного трансплантата предлагается использовать микро-РНК, играющие фундаментальную роль в регуляции активности различных генов. Уровень экспрессии микро-РНК в различных тканях может коррелировать с определенными патологическими состояниями. В настоящем обзоре рассмотрены литературные данные, касающиеся изучения перспектив применения микро-РНК в качестве биомаркеров течения посттрансплантационного периода у реципиентов почечного трансплантата.

Allogeneic kidney transplantation is the optimal approach for the treatment of patients with terminal stage of chronic kidney disease. Moreover, post-transplant monitoring and optimization of immunosuppressive therapy with early non-invasive molecular-biological markers can significantly improve the long-term outcome of transplantation. As markers of damage to the kidney transplant, it is proposed to use micro-RNAs that play a fundamental role in the regulation of the activity of various genes. The level of expression of micro-RNA in different tissues can correlate with certain pathological conditions. In this review, the literature data on the study of the perspectives for the use of micro-RNA as biomarkers of the post-transplantation period in kidney transplant recipients are considered.

микро-РНКтрансплантация почкиострое повреждение почкиострое отторжение трансплантата

micro-RNAkidney transplantationacute kidney injuryacute allograft rejection

References1

Williams WW, Taheri D, Tolkoff-Rubin N, Colvin RB. Clinical role of the renal transplant biopsy. Nat. Rev. Nephrol. 2012; 8 (2): 110–121.

Serуn D, Moreso F. Protocol biopsies in renal transplantation: prognostic value of structuralmonitoring. Kidney Int. 2007; 72 (6): 690–697.

Kozakowski N, Regele H. Biopsy diagnostics in renal allograft rejection: from histomorphology to biological function. Transpl. Int. 2009; 22 (10): 945–953.

Gwinner W. Renal transplant rejection markers. World J. Urol. 2007; 25: 445–455.

Knoll GA. Proteinuria in kidney transplant recipients: prevalence, prognosis, and evidence-based management. Am. J. Kidney Dis. 2009; 54 (6): 1131–1144.

Buob D, Grimbert P, Glowacki F, Labalette M, Dufossé F, Nochy D et al. Three-year outcome of isolated glomerulitis on 3-month protocol biopsies of donor HLA antibody negative patients. Transpl. Int. 2012; 25 (6): 663–670.

Willicombe M, Roufosse C, Brookes P, McLean AG, Galliford J, Cairns T et al. Acute cellular rejection: impact of donor-specific antibodies and C4d. Transplantation. 2014; 97: 433–439.

Weber JA, Baxter DH, Zhang S, Huang DY, Huang KH, Lee MJ et al. The microRNA spectrum in 12 body fluids. Clin. Chem. 2010; 56 (11): 1733–1741.

Allegra A1, Alonci A, Campo S, Penna G, Petrungaro A, Gerace D et al. Circulating microRNAs: new biomarkers in diagnosis, prognosis and treatment of cancer (review). Int. J. Oncol. 2012; 41 (6): 1897–1912.

Xiao YF, Yong X, Fan YH, Lü MH, Yang SM, Hu CJ. MicroRNA detection in feces, sputum, pleural effusion and urine: novel tools for cancer screening (Review). Oncol. Rep. 2013; 30 (2): 535–544.

Chekulaeva M, Filipowicz W. Mechanisms of miRNA mediated post-transcriptional regulation in animal cells. Current Opinion in Cell Biology. 2009; 21 (3): 452–460.

Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004; 116; 2: 281–297.

Аушев ВН. Микро-РНК: малые молекулы с большим значением. Клин. онкогематол. 2015; 8 (1): 1–12. Aushev VN. MicroRNA: small molecules of great significance. Klin. onkogematol. 2015; 8 (1): 1–12.

Zhuo Y, Gao G, Shi JA, Zhou X, Wang X. miRNAs: biogenesis, origin and evolution, functions on virus-host interaction. Cell. Physiol. Biochem. 2013; 32 (3): 499–510.

Ha M, Kim VN. Regulation of microRNA biogenesis. Nat. Rev. Mol. Cell. Biol. 2014; 15 (8): 509–524.

Dalmay T. Mechanism of miRNA-mediated repression of mRNA translation. Essays Biochem. 2013; 54: 29–38.

Valinezhad Orang A, Safaralizadeh R, Kazemzadeh-Bavili M. Mechanisms of miRNA- mediated gene regulation from common downregulation to mRNA-Specific upregulation. Int. J. Genomics. 2014:970607.

Lodish HF, Zhou B, Liu G, Chen CZ. Micromanagement of the immune system by miRNAs. Nat. Rev. Immunol. 2008; 8 (2): 120–130.

Spiegel JC, Lorenzen JM, Thum T. Role of miRNAs in immunity and organ transplantation. Expert Rev. Mol. Med. 2011; 13: e37.

Schrier RW, Wang W, Poole B, Mitra A. Acute renal failure: definitions, diagnosis, pathogenesis, and therapy. J. Clin. Invest. 2004; 114 (1): 5–14.

Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P. Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care (London, England). 2004; 8 (4).

Смирнов АВ, Добронравов ВА, Румянцев АШ, Шилов ЕМ, Ватазин АВ, Каюков ИГ и др. Национальные рекомендации. Острое повреждение почек: основные принципы диагностики, профилактики и терапии. Часть I. Нефрология. 2016; 20 (1): 79–104. Smirnov AV, Dobronravov VA, Rumyantsev AS, Shilov EM, Vatazin AV, Kayukov IG et al. National guidelines. Acute kidney injury: basic principles of diagnosis, prevention and therapy. Part I. Nephrology. 2016; 20 (1): 79–104.

Perico N, Cattaneo D, Sayegh MH, Remuzzi G. Delayed graft function in kidney transplantation. Lancet. 2004; 364: 1814–1827.

Siedlecki A, Irish W, Brennan DC. Delayed graft function in the kidney transplant. Am. J. Transplant. 2011; 11: 2279–2296.

Yarlagadda SG, Coca SG, Formica RN Jr, Poggio ED, Parikh CR. Association between delayed graft function and allograft and patient survival: asystematic review and meta- analysis. Nephrol. Dial. Transplant. 2009; 24: 1039–1047.

Legendre C, Canaud G, Martinez F. Factors influencing long-term outcome after kidney transplantation. Transpl. Int. 2014; 27 (1): 19–27.

Eltzschig HK, Eckle T. Ischemia and reperfusion – from mechanism to translation. Nat. Med. 2011; 17 (11): 1391–1401.

Godwin JG, Ge X, Stephan K, Jurisch A, Tullius SG, Iacomini J. Identification of a microRNA signature of renal ischemia reperfusion injury. Proc. Natl. Acad. Sci. USA. 2010; 107 (32): 14339–14344.

Zarjou A, Yang S, Abraham E, Agarwal A, Liu G. Identification of a microRNA signature in renal fibrosis: role of miR-21. Am. J. Physiol. Renal. Physiol. 2011; 301 (4): 793–801.

Saikumar J, Hoffmann D, Kim TM, Gonzalez VR, Zhang Q, Goering PL et al. Expression, circulation and excretion profile of microRNA-21, -155, and -18a following acute kidney injury. Toxicol. Sci. 2012; 129 (2): 256–267.

Yinfeng M, Jun F, Le Q, Tingting T. Serum miRNA expression and correlation with clinical characteristics in acute kidney injury. Int. J. Clin. Exp. Pathol. 2017; 10 (8): 8721– 8726.

Sui W, Dai Y, Huang Y, Lan H, Yan Q, Huang H. Microarray analysis of MicroRNA expression in acute rejection after renal transplantation. Transpl. Immunol. 2008; 19 (1): 81–85.

Betts G, Shankar S, Sherston S, Friend P, Wood KJ. Examination of serum miRNA levels in kidney transplant recipients with acute rejection. Transplantation. 2014; 97: e28–30.

Tao J, Yang X, Han Z, Lu P, Wang J, Liu X et al. Serum microRNA-99a helps detect acute rejection in renal transplantation. Transplant. Proc. 2015; 47: 1683–1687.

Anglicheau D, Sharma VK, Ding R, Hummel A, Snopkowski C, Dadhania D et al. MicroRNA expression profiles predictive of human renal allograft status. Proc. Natl. Acad. Sci. USA. 2009; 106 (13): 5330–5335.

Matz M, Fabritius K, Lorkowski C, Dürr M, Gaedeke J, Durek P. Identification of T Cell- Mediated Vascular Rejection After Kidney Transplantation by the Combined Measurement of 5 Specific MicroRNAs in Blood Transplantation. 2016; 100 (4): 898–907.

Liu X, Dong C, Jiang Z, Wu WK, Chan MT, Zhang J et al. MicroRNA-10b downregulation mediates acute rejection of renal allografts by derepressing BCL2L11. Exp. Cell Res. 2015; 333 (1): 155–163.

Misra MK, Pandey SK, Kapoor R, Sharma RK, Agrawal S. Genetic variants of MicroRNA-related genes insusceptibility and prognosis of end-stage renal disease and renal allograft outcome among north Indians. Pharmacogenetics and Genomics. 2014; 24 (9): 442–450.

Bijkerk R, Florijn BW, Khairoun M, Duijs JMGJ, Ocak G, de Vries APJ et al. Acute rejection after kidney transplantation associates with circulating microRNAs and vascular injury. Transplant. Direct. 2017; 3 (7): e174.

Scian MJ, Maluf DG, David KG, Archer KJ, Suh JL, Wolen AR et al. MicroRNA profiles in allograft tissues and paired urines associate with chronic allograft dysfunction with IF/TA. Am. J. Transplant. 2011; 11 (10): 2110–2122.

Glowacki F, Savary G, Gnemmi V, Buob D, Van der Hauwaert C, Lo-Guidice JM et al. Increased circulating miR-21 levels are associated with kidney fibrosis. PLoS One. 2013; 8 (2): e58014.

Danger R, Paul C, Giral M, Lavault A, Foucher Y, Degauque N. et al. Expression of miR-142-5p in Peripheral Blood Mononuclear Cells from Renal Transplant Patients with Chronic Antibody-Mediated Rejection. PLoS One. 2013; 8 (4): e60702.

Chen J, Zmijewska A, Zhi D, Mannon R B. Cyclosporine-mediated allograft fibrosis is associated with micro- RNA-21 through AKT signaling. Transpl. Int. 2015; 28: 232–245.

Yuan J, Benway CJ, Bagley J, Iacomini J. Micro-RNA-494 promotes cyclosporine- induced nephrotoxicity and epithelial to mesenchymal transition by inhibiting PTEN. Am. J. Transplant. 2015; 15: 1682–1691.

Lodes MJ, Caraballo M, Suciu D, Munro S, Kumar A, Anderson B. Detection of cancer with serum miRNAs on an oligonucleotide microarray. PLoS One. 2009; 4: e 6229.

Lawrie CH, Gal S, Dunlop HM, Pushkaran B, Liggins AP, Pulford K et al. Detection of elevated levels of tumour associated microRNAs in serum of patients with diffuse large b-cell lymphoma. Br. J. Haematol. 2008; 141: 672–675.

Tam S, de Borja R, Tsao MS, McPherson JD. Robust global microrna expression profiling using next-generation sequencing technologies. Lab. Invest. 2014; 94: 350– 358.

Chen Y, Gelfond JA, McManus LM, Shireman PK. Reproducibility of quantitative RT- PCR array in miRNA expression profiling and comparison with microarray analysis. BMC Genomics. 2009; 10: 407.

Linsen SE, de Wit E, Janssens G, Heater S, Chapman L, Parkin RK et al. Limitations and possibilities of small RNA digital gene expression profiling. Nat. Methods. 2009; 6: 474–476.

Sablok G, Milev I, Minkov G, Minkov I, Varotto C, Yahubyan G et al. Isomirex: Web- based identification of microRNAs, isomir variations and differential expression using next generation sequencing datasets. FEBS Lett. 2013; 587: 2629–2634.

Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, Nguyen JT et al. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res. 2005; 33: e179.

The authors declare that there are no conflicts of interest present.