In this study 71 patients (61 male and 10 female) were included, who have been operated in our institute from 1987 to 2006. All of them were undergoing orthotopic heart transplantation. The age of patients was from 14 to 57 years (the mean age 34,5). Only patients who were discharged from the hospital were included in the study. For statistical analysis Kaplan-Mayer survival analysis, relative risks (RR) and ODDR, proportional hazard risks regression of Cox were used. Coronary arteries disease was identifi ed as risk factor for long-term survival prognosis. Types B1, B2 and C arteriopathy are very unfavorable for long-term survival prognosis.

Percutaneus coronary intervention for type A improves long-term survival prognosis in comparison with types B and C.

There was an analysis restoration of sinus node normal function after heart transplantation. The terms mode restore normal activity of sinus node dysfunction with his appearance. It’s offered to classify sinus node dysfunction in terms of the emergence on the early (the period of functional adaptation of transplanted heart during the fi rst month after transplantation) and late (resulting in posthospital period), as well as on the stability degree – transient (temporary) and persistent (permanent form).

There’s an estimation of tricuspid dysfunction detection of various degrees in posttransplant period depending on operation technique. The article presents the dependence of development tricuspid dysfunction up to 1 st. degree from the level of transpulmonary gradient, which is integrated index of pulmonary hypertension level and which doesn’t change over postransplant period. In this research tricuspid dysfunction of 2–3 degrees most frequently detected in the remote period after heart transplantation or was the result of any postransplant complication.

The paper presents the experience with plasmapheresis in the treatment of сoronary artery disease with drug therapy. 19 recipients at different time after cardiac transplantation with coronary artery disease confi rmed by angiography were treated by therapeutic plasmapheresis courses. The effectiveness was estimated by radioisotope, immunomorphological and laboratory methods. After the course there were increase of regional and local myocardium contractility, increase in left ventricle ejection fraction, reducing intraventricular asynchrony, permission immunocomplex syndrome and lack of local intravascular blood coagulation. Plasmapheresis is considered as a promising method for the impact on the factors contributing to the accelerated nature of the development of coronary arteries lesions in transplanted heart.

The aim of this study was morphological characteristics of peculiar properties of acute T-cells- (ATMR) and antibody-mediated kidney allograft rejection (AAMR). Histological slices of kidney allograft biopsies were examined after coloration by routine methods and immunohistochemical proceeding for C4d, CD45R0 T-lymphocytes antigen and CD68 macrophages antigen. We’ve determined that the key features of ATMR are: increasing of T-lymphocytes interstitial infi ltration with the same level of macrophages infi ltration comparing with implantation biopsies, mild mononuclear glomerulitis and capillaritis; tubulitis. Morphological traits of AAMR are neutrophilic and T-lymphocytes glomerulitis, diffuse capillaritis, capillaries dilatation and margination of mononuclear cells with admixture of neutrophils, macrophagal interstitial infi ltration under semiquantitative evaluation, as well as, more pronounced, than in ATMR, T-lymphoctes and macrophages interstitial infi ltration under quantitative evaluation.

The study included 15 consecutive patients with heart failure and substantial LV dyssynchrony undergoing CRT. Clinical and phase analysis of gated myocardial perfusion SPECT assessed at baseline, after 2–3 days and after 3–4 months of CRT. The results demonstrated inversely relationship between the response to CRT and the nonviable myocardium. Evaluation of myocardial viability is necessary to considered in the selection process for CRT.

The conditions which are necessary for successful functioning of implants based on polymer matrix having the structure of a chaotic three-dimensional grid are analyzed. The investigation is aimed on the development of techniques for manufacturing the volumetric structured matrixes from polymer biocompatible materials and techniques of implant creation by electro-physical surface treatment of the matrix structure with the purpose of management of their biochemical and biological activity. Morphological characteristics of the matrixes, produced by the method of freeze-drying of the polymeric gel are reported. The complex energy system created for volumetric discharges generation in the structured heterogeneous substances is described. 

New implant materials for regenerative and replacement surgery based on biodegradable polymers like collagens and polyoxybutirates are developed. Porous structures with controllable morphology were formed from biodegradable polymers using electrospinning and bioprinting technologies. The matrixes were studied by visible and electron scanning microscopy as well as INTEGRA Tomo scanning probe platform making possible the restoration of inner 3D structure of polymer matrix. 

We studied the viability and dynamic of cell distribution during long-term cultivation of broblasts 3T3 in spider silk spidroin 1-based scaffold. Laser scanning confocal microscopy is shown to have advantages for visualization of cells situated on the external and internal surfaces of scaffold. Fibroblasts maintain high proliferative ability and viability during long term cultivation. Spidroin 1-based scaffold are the perspective materials for bioengineering. 

The article presents analysis of scientific literature of the last 15 years about complications after orthotopic liver transplantation, depending on the severity of the initial status of recipient and expression of metabolic and functional disorders. Factors affecting the development of vascular complications (arterial and venous thrombosis), biliary complications (cholestasis, cholangitis), immune response (acute rejection), and also surgical and infectious complications and functional insufficiency of the graft are analyzed in this review. The necessity to improve monitoring in the immediate post transplant period is considered. 

In this review the modern conception of development of autoimmune diabetes mellitus was presented. Possibilities of immune disturbances correction and β-cells regeneration at transplantation of bone marrow and umbilical cord blood cells were considered.