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Вестник трансплантологии и искусственных органов

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Механизм развития гуморального иммунного ответа на аллогенную трансплантацию орг

https://doi.org/10.15825/1995-1191-2017-2-139-151

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Аннотация

Проблема гуморального, антителоопосредованного отторжения донорского органа остается крайне актуальной. Главной мишенью антител в основном являются донорские HLA-антигены (Human Leucocyte Antigens), экспрессируемые, в частности, клетками сосудистого эндотелия трансплантата. В данном обзоре рассматриваются механизмы развития гуморального аллоиммунитета, в основе которых лежит распознавание В-клетками реципиента эпитопов донорских HLA-молекул и созревание аффинности В‑клеточных рецепторов в герминативных центрах периферической лимфатической системы. Учет показателей эпитопной нагрузки и кросс-реактивности при анализе HLA-совместимости донора и реципиента играет важную роль в профилактике гуморального отторжения аллогенного трансплантата.

Об авторах

А. С. Беркос
ФГБУ «Российский НИИ гематологии и трансфузиологии ФМБА России»
Россия


Г. В. Николаев
ФГБУ «Северо-Западный федеральный медицинский исследовательский центр» Минздрава России
Россия


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Для цитирования:


Беркос А.С., Николаев Г.В. Механизм развития гуморального иммунного ответа на аллогенную трансплантацию орг. Вестник трансплантологии и искусственных органов. 2017;19(2):139-151. https://doi.org/10.15825/1995-1191-2017-2-139-151

For citation:


Berkos A.S., Nikolaev G.V. The mechanism of humoral immune response to allogeneic organ transplantation. Russian Journal of Transplantology and Artificial Organs. 2017;19(2):139-151. (In Russ.) https://doi.org/10.15825/1995-1191-2017-2-139-151

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ISSN 1995-1191 (Print)
ISSN 2412-6160 (Online)