References

vtio

Вестник трансплантологии и искусственных органов

Russian Journal of Transplantology and Artificial Organs

1995-1191

Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation

10.15825/1995-1191-2017-2-139-151

vtio-762

Research Article

Обзор литературы

Literature Reviews

Механизм развития гуморального иммунного ответа на аллогенную трансплантацию орг

The mechanism of humoral immune response to allogeneic organ transplantation

Беркос

А. С.

Berkos

A. S.

aberkos@yandex.ru

Николаев

Г. В.

Nikolaev

G. V.

ФГБУ «Российский НИИ гематологии и трансфузиологии ФМБА России»РоссияRussian Research Institute of Hematology and TransfusiologyRussian Federation

ФГБУ «Северо-Западный федеральный медицинский исследовательский центр» Минздрава РоссииРоссияFederal State Budgetary Institution Federal Almazov North-West Medical Research Centre of the Ministry of Healthcare of the Russian FederationRussian Federation

2017

23062017

192139151

2017

Беркос А.С., Николаев Г.В.

Berkos A.S., Nikolaev G.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.transpl.ru/vtio/article/view/762

Проблема гуморального, антителоопосредованного отторжения донорского органа остается крайне актуальной. Главной мишенью антител в основном являются донорские HLA-антигены (Human Leucocyte Antigens), экспрессируемые, в частности, клетками сосудистого эндотелия трансплантата. В данном обзоре рассматриваются механизмы развития гуморального аллоиммунитета, в основе которых лежит распознавание В-клетками реципиента эпитопов донорских HLA-молекул и созревание аффинности В‑клеточных рецепторов в герминативных центрах периферической лимфатической системы. Учет показателей эпитопной нагрузки и кросс-реактивности при анализе HLA-совместимости донора и реципиента играет важную роль в профилактике гуморального отторжения аллогенного трансплантата.

The problem of antibody-mediated rejection of donor organ remains extremely relevant. The main targets of the antibodies are mainly donor HLA-antigens (Human Leucocyte Antigens), expressed, in particular, by the cells of graft vascular endothelium. This review describes the mechanisms of the development of humoral alloimmunity which are based on B-cell recognition of epitopes of donor HLA-molecules and affinity maturation of B-cell receptors in the germinal centers of peripheral lymphatic system. Monitoring of epitope load and cross-reactivity indicators to evaluate HLA-compatibility of donor and recipient plays an important role in the prevention of allograft humoral rejection.

гуморальное отторжениеаллогенный трансплантатHLA-антигеныВ-клеточные рецепторыгерминативные центрыэпитопыкросс-реактивность

humoral rejectionallograftHLA-antigensB-cell receptorsgerminal centersepitopescrossreactivity

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The authors declare that there are no conflicts of interest present.