THE ROLE OF PROTOCOL BIOPSIES IN EARLY PERIOD AFTER KIDNEY TRANSPLANTATION
https://doi.org/10.15825/1995-1191-2010-2-33-36
Abstract
46 protocol graft biopsies with the subsequent histological examination were performed in 39 patients after kidney transplantation. In 20 patients with stable graft function acute subclinical rejection were revealed in 12 (60%) with the following steroid therapy. In 19 patients with delayed kidney graft function acute rejection was revealed in 13 (68,4%). Treatment by steroids was successful and function renewed. Our results showed that protocol biopsy is a safe and reliable method that allows to recognize such kidney graft pathology as subclinical rejection and to perform its treatment in time.
About the Authors
V. A. Suhorukov
Latvian transplant center, Riga
Russian Federation
Russian Federation
Y. L. Yushinskis
Latvian transplant center, Riga
Russian Federation
Russian Federation
I. Shtrumfa
Latvian transplant center, Riga
Russian Federation
Russian Federation
R. L. Rozental
Latvian transplant center, Riga
Russian Federation
Russian Federation
References
1. Пункционная биопсия является практически безвредной процедурой, позволяющей получить существенную информацию о состоянии почеч- ного трансплантата.
2. Протокольная биопсия функционирующего трансплантата может давать дополнительные данные о его состоянии и основания для прове- дения антикризовой терапии.
3. Приотсроченнойфункциипочечноготрансплан- тата протокольная биопсия может служить мето- дом выбора как диагностическая процедура.
4. СПИСОК ЛИТЕРАТУРЫ
5. Danovitch G. Handbook of kidney transplantation // 4th edition Lippincot Wiliams and Wilkens. 2005. 539 p.
6. Kanetsuna Y., Yamaguchi Y., Hiroshi T., Tanabe K. His- tological evaluation of renal allograft protocol biopsies in the early period and 1 year after transplantation // Clin. Transplant. 2003. Vol. 17 (10). P. 25–29.
7. KDIGO Clinical practice guideline for the care of kidney transplant recipients. Am. J. Transplant. 2009. Vol. 9 (3). Р. S30–S32.
8. Meier-Kriesche H.U., Schold E.D., Srinivas T.R. Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era // Am. J. Transplant. Vol. 4 (3). Р. 378– 383.
9. Moreso F., Ibernon M., Goma M. et al. Subclinical re- jection associated with chronic allograft nephropathy in protocol biopsies as a risk factor for late graft loss // Am. J. Transplant. 2006. Vol. 6. Р. 747–752.
10. Nankivell B.J., Chapmen J.R. The significance of subcli- nical rejection and the value of protocol biopsies // Am. J. Transplant. 2006. Vol. 6. Р. 2006–2012.
11. Oureshie F., Rabb H., Kasiske B.L. Silent acute rejection during prolonged delayed graft function reduced kid- ney allograft survival // Transplantation. 2002. Vol. 74. Р. 1400–1404.
12. Ruch D.N., Karpinski M.E., Nickerson P. et al. Does sub- clinical rejection contribute to chronic rejection in renal transplant patients? // Clin. Transplant. 1999. Vol. 13. Р. 441–446.
13. Seron D., Moreso F. Protocol biopsies in renal transplan- tation: prognostic value of structural monitoring // Kid- ney Int. 2007. Vol. 72. Р. 690–697.
14. Solez K., Colvin R.B., Racusen L.C. et al. Banff 07 clas- sification of renal allograft pathology: updates and fu- ture directions // Am. J. Transplant. 2008. Vol. 8. Р. 753– 760.
15. Suhorukov V., Tihomirova T., Yushinskis Y., Ziedina I., Rozental R. «Silent» rejection during delayed kidney graft function // Transplant. Int. 2009. Vol. 22 (2). 188 р.
Review
For citations:
Suhorukov V.A., Yushinskis Y.L., Shtrumfa I., Rozental R.L. THE ROLE OF PROTOCOL BIOPSIES IN EARLY PERIOD AFTER KIDNEY TRANSPLANTATION. Russian Journal of Transplantology and Artificial Organs. 2010;12(2):33-36. (In Russ.) https://doi.org/10.15825/1995-1191-2010-2-33-36
Views:
893
Email this article 