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Вестник трансплантологии и искусственных органов

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Особенности течения злокачественных новообразований на фоне иммуносупрессивной терапии у реципиентов сердца

https://doi.org/10.15825/1995-1191-2021-2-167-176

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Аннотация

По мере улучшения выживаемости реципиентов сердца существенное значение для их прогноза приобретает более частое развитие злокачественных новообразований в позднем послеоперационном периоде. Иммуносупрессивная терапия – одно из ключевых условий, необходимых для успешной трансплантации, однако длительное использование иммунодепрессантов повышает частоту заболеваемости злокачественными новообразованиями по сравнению с общей популяцией. Риск их развития после трансплантации органов увеличивается в 2–4 раза по сравнению с популяцией в целом. Для пациентов, перенесших трансплантацию с 2000 г., риск развития злокачественных новообразований через 1–5 лет после операции оценивается в 10–12%. Своевременное комплексное обследование пациентов, разработка новых схем иммуносупрессии, лечение инфекций, предрасполагающих к развитию злокачественных новообразований, отказ от вредных привычек позволят снизить риски возникновения злокачественных новообразований и помогут диагностировать эти серьезные осложнения на ранних стадиях, что, в свою очередь, увеличит продолжительность жизни реципиентов солидных органов, в частности сердца.

Об авторах

Л. Б. Круглый
ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России
Россия

Круглый Лев Борисович

123182, Москва, ул. Щукинская, д. 1



Н. Н. Колоскова
ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России
Россия

Москва



А. В. Никулин
ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России
Россия

Москва



И. В. Пашков
ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России
Россия

Москва



В. Н. Попцов
ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России
Россия

Москва



А. О. Шевченко
ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский университет)
Россия

Москва



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Для цитирования:


Круглый Л.Б., Колоскова Н.Н., Никулин А.В., Пашков И.В., Попцов В.Н., Шевченко А.О. Особенности течения злокачественных новообразований на фоне иммуносупрессивной терапии у реципиентов сердца. Вестник трансплантологии и искусственных органов. 2021;23(2):167-176. https://doi.org/10.15825/1995-1191-2021-2-167-176

For citation:


Krougly L.B., Koloskova N.N., Nikulin A.V., Pashkov I.V., Poptsov V.N., Shevchenko A.O. Сlinical features of malignant tumors against the background of immunosuppressive therapy in heart transplant recipients. Russian Journal of Transplantology and Artificial Organs. 2021;23(2):167-176. (In Russ.) https://doi.org/10.15825/1995-1191-2021-2-167-176

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ISSN 1995-1191 (Print)
ISSN 2412-6160 (Online)