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Противовирусная терапия гепатита С 1 генотипа после трансплантации печени

https://doi.org/10.15825/1995-1191-2018-3-105-115

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Аннотация

Хроническая HCV-инфекция является ведущей причиной трансплантации печени взрослым в развитых странах. К сожалению, реинфицирование трансплантата неизбежно происходит у всех  пациентов с сохраняющейся репликацией вируса. На фоне необходимой иммуносупрессивной  терапии прогрессирование заболевания ускоряется, приводя к быстрой декомпенсации печени.  Проведение противовирусной терапии значительно улучшает результаты трансплантации, однако  применение стандартных схем на основе интерферона сопряжено с низкой эффективностью (не  более 30% для наиболее распространенного 1-го генотипа вируса) и плохой переносимостью. В  статье описаны новые безинтерфероновые пероральные режимы терапии, применяемые для лечения рецидива HCV-инфекции 1-го генотипа.

Об авторах

О. М. Цирульникова
ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский университет)
Россия


Д. В. Умрик
ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России
Россия

Адрес: 123182, Москва, ул. Щукинская, д. 1. Тел. (926) 434-16-24



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Для цитирования:


Цирульникова О.М., Умрик Д.В. Противовирусная терапия гепатита С 1 генотипа после трансплантации печени. Вестник трансплантологии и искусственных органов. 2018;20(3):105-115. https://doi.org/10.15825/1995-1191-2018-3-105-115

For citation:


Tsiroulnikova O.M., Umrik D.V. Antiviral therapy of hepatitis C with 1 genotype after liver transplantation. Russian Journal of Transplantology and Artificial Organs. 2018;20(3):105-115. (In Russ.) https://doi.org/10.15825/1995-1191-2018-3-105-115

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ISSN 1995-1191 (Print)
ISSN 2412-6160 (Online)