PATHOMORPHОLOGY OF BILIARY ATRESIA IN CHILDREN – RECIPIENT OF LIVER
https://doi.org/10.15825/1995-1191-2013-4-47-54
Abstract
Aim of the work. Сlinical and morphological research of the features of biliary atresia at children-recipients of liver, to whom a portoenterostomy was made in comparison with patients to whom such surgery wasn't carried out.
Materials and methods. Clinical records and histological research of liver of 49 children suffering a bili- ary atresia are analyzed. Two groups were created: the 1st group – 21 children without portoenterostomy before liver transplantation and 2nd group – 28 children with portoenterostomy before liver transplantation.
Results. Pathomorphology of liver the characteristics in structure of proliferation bile ducts are established: hypostasis and dystrophic changes of cholangiocytes at patients of the first group (p = 0,035) and sclerosis of bile ducts with disappearance of an epithelium at patients of the second group (p = 0,01). In first group of children activity of inflammatory process in liver were significantly higher than in second group (p = 0,02).
Conclusion. Our experi- ence has demonstrated that portoenterostomy doesn’t prevent fibrosis of intrahepatic bile ducts and development of fibrosis, and then a development of cirrhosis.
About the Authors
O. E. Iryshkin
Academician V.I. Shumakov Federal Research Center of Transplantjlogy and Artificial Organs (Director – academic of RAMSci, prof. S.V. Gautier), Moscow, Russian Federation
I. M. Iljinsky
Academician V.I. Shumakov Federal Research Center of Transplantjlogy and Artificial Organs (Director – academic of RAMSci, prof. S.V. Gautier), Moscow, Russian Federation
Chair of transplantology and artificial organs (Head – academician of RAMSci, prof. S.V. Gautier) I.M. Sechenov First Moscow State Medical University (Rector – corresponding member of RAMSci, prof. P.V. Glybochko), Moscow, Russian Federation
O. M. Tsirulnikova
Academician V.I. Shumakov Federal Research Center of Transplantjlogy and Artificial Organs (Director – academic of RAMSci, prof. S.V. Gautier), Moscow, Russian Federation
Chair of transplantology and artificial organs (Head – academician of RAMSci, prof. S.V. Gautier) I.M. Sechenov First Moscow State Medical University (Rector – corresponding member of RAMSci, prof. P.V. Glybochko), Moscow, Russian Federation
S. V. Gautier
Academician V.I. Shumakov Federal Research Center of Transplantjlogy and Artificial Organs (Director – academic of RAMSci, prof. S.V. Gautier), Moscow, Russian Federation
Chair of transplantology and artificial organs (Head – academician of RAMSci, prof. S.V. Gautier) I.M. Sechenov First Moscow State Medical University (Rector – corresponding member of RAMSci, prof. P.V. Glybochko), Moscow, Russian Federation
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Review
For citations:
Iryshkin O.E., Iljinsky I.M., Tsirulnikova O.M., Gautier S.V. PATHOMORPHОLOGY OF BILIARY ATRESIA IN CHILDREN – RECIPIENT OF LIVER. Russian Journal of Transplantology and Artificial Organs. 2013;15(4):47-54. (In Russ.) https://doi.org/10.15825/1995-1191-2013-4-47-54
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