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Вестник трансплантологии и искусственных органов

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БИОМАРКЕРЫ ИММУННОЙ ТОЛЕРАНТНОСТИ ПРИ ТРАНСПЛАНТАЦИИ ПЕЧЕНИ

https://doi.org/10.15825/1995-1191-2016-3-137-144

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Аннотация

Обзор литературы посвящен анализу исследований биомаркеров, позволяющих прогнозировать формирование иммунной толерантности и идентифицировать пациентов, которым можно безопасно минимизировать иммуносупрессию после трансплантации печени. В обзоре проанализированы 46 источников литературы, большая часть которых опубликована в последние пять лет. В настоящее время бурно развиваются новые технологии, позволяющие понять молекулярные механизмы нормальных, патологических и фармакологических процессов, протекающих при трансплантации органов. Однако до настоящего времени нет биомаркеров, валидированных для определения состояния иммунной толерантности и индивидуального подбора иммуносупрессантов. Накопление данных по пациентам вкупе с совершенствованием биоинформатики может значительно ускорить процесс развития подходов для стратификации пациентов. 

Об авторах

О. П. Шевченко
ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России, Москва; ГБОУ ВПО «Первый МГМУ имени И.М. Сеченова», Москва
Россия

Кафедра трансплантологии и искусственных органов

123182, Москва, ул. Щукинская, 1. Тел. (499) 190-38-77



Р. М. Курабекова
ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России, Москва
Россия


О. М. Цирульникова
ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России, Москва; ГБОУ ВПО «Первый МГМУ имени И.М. Сеченова», Москва
Россия
Кафедра трансплантологии и искусственных органов


Список литературы

1. Adams DH, Sanchez-Fueyo A, Samuel D. From immunosuppression to tolerance. J. Hepatol. 2015; 62: 170–185.

2. Готье СВ. Трансплантология: итоги и перспективы. Том VI. 2014 год. М.–Тверь: Триада; 2015. 448 с. Gautier SV. Transplantologiya: itogi i perspectivy. Tom VI. 2014 god. M.–Tver: Triada; 2015. 448. [In Russian]

3. Marcen R. Immunosuppressive drugs in kidney transplantation: impact on patient survival, and incidence of cardiovascular disease, malignancy and infection. Drugs. 2009; 69 (16): 2227–2243.

4. Ekberg H, Bernasconi C, Noldeke J, Yussim A, Mjornstedt L, Erken U et al. Cyclosporine, tacrolimus and sirolimus retain their distinct toxicity profi les despite low doses in the Symphony study. Nephrol. Dial. Transplant. 2010; 25 (6): 2004–2010.

5. Heidt S, Wood KJ. Biomarkers of Operational Tolerance in Solid Organ Transplantation. Expert Opin. Med. Diagn. 2012; 6 (4): 281–293.

6. Benitez C, Londono MC, Miquel R, Manzia TM, Abral￾des JG, Lozano JJ et al. Prospective multicenter clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients. Hepatology. 2013; 58 (5): 1824–1835.

7. Schildberg FA, Hegenbarth SI, Schumak B, Scholz K, Limmer A, Knolle PA. Liver sinusoidal endothelial cells veto CD8 T-cell activation by antigen-presenting dendritic cells. Eur. J. Immunol. 2008; 38 (4): 957–967.

8. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T-cells. Nature. 2006; 441 (7090): 235–238.

9. Marie JC, Liggitt D, Rudensky AY. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T-cell-specifi c targeting of transforming growth factor-beta receptor. Immunity. 2006; 25 (3): 441–454.

10. Li MO, Wan YY, Flavell RA. T cell-produced transforming growth factor-beta1 controls T-cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity. 2007; 26 (5): 579–591.

11. Charles R, Chou HS, Wang L, Fung JJ, Lu L, Qian S. Human hepatic stellate cells inhibit T-cell response through B7-H1 pathway. Transplantation. 2013; 96 (1): 17–24.

12. Jiang Z, Chen Y, Feng X, Jiang J, Chen T, Xie H et al. Hepatic stellate cells promote immunotolerance following orthotopic liver transplantation in rats via induction of T-cell apoptosis and regulation of Th2/Th3-like cell cytokine production. Exp. Ther. Med. 2013; 5 (1): 165–169.

13. Sanchez-Fueyo A, Strom TB. Immunologic basis of graft rejection and tolerance following transplantation of liver or other solid organs. Gastroenterology. 2011; 140 (1): 51–64.

14. Owen RD. Immunogenetic Consequences of Vascular Anastomoses between Bovine Twins. Science. 1945; 102 (2651): 400–401.

15. Billingham RE, Brent L, Medawar PB. Actively acquired tolerance of foreign cells. Nature. 1953; 172 (4379): 603–606.

16. Starzl TE. Clinical and basic scientifi c implications of cell migration and microchimerism after organ transplantation. Artif. Organs. 1997; 21 (11): 1154–1155.

17. Wu SL, Pan CE. Tolerance and chimerism and allogeneic bone marrow/stem cell transplantation in liver transplantation. World J. Gastroenterol. 2013; 19 (36): 5981–5987.

18. Leventhal J, Miller J, Abecassis M, Tollerud DJ, Il dstad ST. Evolving Approaches of Hematopoietic Stem Cell – Based Therapies to Induce Tolerance to Organ Transplants: The Long Road to Tolerance. Clinical Pharmacology & Therapeutics. 2013; 93 (1): 36–45.

19. Scandling JD, Busque S, Dejbakhsh-Jones S, Benike C, Sarwal M, Millan MT et al. Tolerance and withdrawal of immunosuppressive drugs in patients given kidney and hematopoietic cell transplants. Am. J. Transplant. 2012; 12 (5): 1133–1145.

20. Bishop GA, Wang C, Sharland AF, McCaughan G. Spontaneous acceptance of liver transplants in rodents: evidence that liver leucocytes induce recipient T-cell death by neglect. Immunol. Cell Biol. 2002; 80 (1): 93–100.

21. Hamawy MM, Knechtle SJ. Strategies for tolerance induction in nonhuman primates. Curr. Opin. Immunol. 1998; 10 (5): 513–517.

22. Kawai T, Cosimi AB, Sachs DH. Preclinical and clinca l studies on the induction of renal allograft tolerance through transient mixed chimerism. Curr. Opin. Organ Transplant. 2011; 16 (4): 366–371.

23. Torrealba JR, Fernandez LA, Kanmaz T, Oberley TD, Schultz JM, Brunner KG et al. Immunotoxin-treated rhesus monkeys: a model for renal allograft chronic rejection. Transplantation. 2003; 76 (3): 524–530.

24. Page EK, Dar WA, Knechtle SJ. B iologics in organ transplantation. Transpl. Int. 2012; 25 (7): 707–719.

25. Page EK, Dar WA, Knechtle SJ. Tolerogenic therapies in transplantation. Front Immunol. 2012; 3 (198).

26. Suthanthira n M, Schwartz JE, Ding R, Abecassis M, Dadhania D, Samstein B et al. Urinary-cell mRNA pro- fi le and acute cellular rejection in kidney allografts. N. Engl. J. Med. 2013; 369 (1): 20–31.

27. Vitalone MJ, Wei L, Fujiki M, Lau AH, Littau E, Esqui￾vel C et al. Liver microRNA Profi le of Induced Allograft Tole rance. Transplantation. 2016; 100 (4): 781–790.

28. Mastoridis S, Martinez-Llordella M, Sanchez-Fueyo A. Emergent Transcriptomic Technologies and Their Role in the Discovery of Biomarkers of Liver Transplant Tolerance. Front Immunol. 2015; 6 (304).

29. Baron D, Ramstein G, Chesneau M, Echasseriau Y, Pallier A, Paul C e t al. A common gene signature across multiple studies relate biomarkers and functional regulation in tolerance to renal allograft. Kidney Int. 2015; 87 (5): 984–995.

30. Machina HK, Wild DJ. Laboratory Informatics Too ls Integration Strategies for Drug Discovery Integration of LIMS, ELN, CDS, and SDMS. Journal of laboratory automation. 2013; 18 (2): 126–136.

31. Voegele C, Tavtigian SV, de Silva D, Cuber S, Thomas A, Le C alvez-Kelm F. A Laboratory Information Management System (LIMS) for a high throughput genetic platform aimed at candidate gene mutation screening. Bioinformatics. 2007; 23 (18): 2504–2506.

32. Курабекова РМ, Бельченков АА, Олефиренко ГА, Макарова ЛВ, Кангизер АА, Шевченко ОП. Опыт автоматизации работы научно-исследовательской лаборатории с использованием стандартной лабораторной информационной системы. Лаборатория. 2015; (3): 19–22. Kurabekova RM, Belchenkov AA, Olefi renko GA, Makarova LV, Kangizer AA, Shevchenko OP. Opyt avtomatizacii raboty nauchno-issledovatel`skoi laboratorii s ispol`sovaniem standartnoi laboratornoi informacionnoi sistemy. Laboratoria. 2015; (3): 19–22. [Russian]

33. Курабекова РМ, Шевченко ОП, Цирульникова ОМ, Олефиренко ГА, Гичкун ОЕ, Цирульникова ИЕ и др. Биомаркеры у детей – реципиентов печени. Свидетельство о государственной регистрации базы данных № 2015620210; 2015. Kurabekova RM, Shevchenko OP, Tsirulnikova OM, Olefi renko GA, Gichkun OE, Tsirulnikova IE et al. Biomarkery u detey – recipientov pecheni. Svidetel`stvo o gosudarstvennoi registracii bazy dannykh № 2015620210; 2015. [Russian]

34. Pham MX, Teuteberg JJ, Kfoury A G, Starling RC, Deng MC, Cappola TP et al. Gene-expression profi ling for rejection surveillance after cardiac transplantat ion. N. Engl. J. Med. 2010; 362 (20): 1890–1900.

35. Weiss JM, Subleski JJ, Back T, Chen X, Watkins SK, Yagita H et al. Regulatory T cells and myeloid-derived suppres sor cells in the tumor microenvironment undergo Fas-dependent cell death during IL-2/alphaCD40 therapy. J. Immunol. 2014; 192 (12): 5821–5829.

36. Hu M, Wang C, Zhang GY, Sa ito M, Wang YM, Fernandez MA et al. Infi ltrating Foxp3(+) regulatory T-cells from spontaneously tolerant kidney allografts demonstrate donor-specifi c tolerance. Am. J. Transplant. 2013; 13 (11): 2819–2830.

37. Zhao X, Li Y, Ohe H, Nafady-Hego H, Uemoto S, Bisho p GA et al. Intragraft Vdelta1 gammadelta T-cells with a unique T-cell receptor are closely associated with pediatric semiallogeneic liver transplant tolerance. Transplantation. 2013; 95 (1): 192–202.

38. Lozano JJ, Pallier A, Martinez-Llorde lla M, Danger R, Lopez M, Giral M et al. Comparison of transcriptional and blood cell-phenotypic markers between operationally tolerant liver and kidney recipients. Am. J. Transplant. 2011; 11 (9): 1916–1926.

39. Li L, Wo zniak LJ, Rodder S, Heish S, Talisetti A, Wang Q et al. A common peripheral blood gene set for diagnosis of operational tolerance in pediatric and adult liver trans￾plantation. Am. J. Transplant. 2012; 12 (5): 1218–1228.

40. Bohne F, Martinez-Llordella M, Lozano JJ, Miquel R, Benitez C, Londono MC et al. Intra-graft expression of g enes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation. J. Clin. Invest. 2012; 122 (1): 368–382.

41. Wei L, Gong X, Martinez OM, Krams SM. Different ial expression and functions of microRNAs in liver trans￾plantation and potential use as non-invasive biomark ers. Transpl. Immunol. 2013; 29 (1–4): 123–129.

42. Morita M, Chen J, Fujino M, Kitazawa Y, Sugioka A, Zho ng L et al. Identifi cation of microRNAs involved in acute rejection and spontaneous tolerance in murine hepatic allografts. Sci. Rep. 2014; 4 (6649).

43. Xie QY, Almudevar A, Whitney-Miller CL, Barry C T, McCall MN. A microRNA biomarker of hepatocellular carcinoma recurrence following liver transplantation accounting for within-patient heterogeneity. BMC Med. Genomic s. 2016; 9 (1): 016–0179.

44. Gautier SV, Shevchenko OP, Tsirulnikova OM, Kurabekova RM, Lugovskaya SA, Naumova EV et al. The hematopoietic stem cell number in the peripheral blood of pediatric recipie nts correlates with the outcome after living donor liver transplantation. Pediatr. Transplant. 2015; 19 (5): 531–537.

45. Schlickeiser S, Boes D, Streitz M, Sawitzki B. The use of novel diagnostics to individualize immunosuppression follo wing transplantation. Transpl. Int. 2015; 28 (8): 911–920.

46. Шевченко ОП, Цирульникова ОМ, Курабекова РМ, Цирульникова ИЕ, Олефиренко ГА, Готье СВ. Уровень трансформирующего фактора роста β1 в плазме крови детей – реципиентов печени и его связь с функцией трансплантата. Иммунология. 2015; 36 (6): 343–347. Shevchenko OP, Tsirulnikova OM, Kurabekova RM, Tsirulnikova IE, Olefi renko GA, Gautier SV. Blood plasma level of transforming growth factor β1 in pediatric liver transplant recipients and its relationship with graft function. Immunologiya. 2015; 36 (6): 343–347 [In Russian (abstract in English)].


Рецензия

Для цитирования:


Шевченко О.П., Курабекова Р.М., Цирульникова О.М. БИОМАРКЕРЫ ИММУННОЙ ТОЛЕРАНТНОСТИ ПРИ ТРАНСПЛАНТАЦИИ ПЕЧЕНИ. Вестник трансплантологии и искусственных органов. 2016;18(3):137-144. https://doi.org/10.15825/1995-1191-2016-3-137-144

For citation:


Shevchenko O.P., Kurabekova R.M., Tsiroulnikova O.M. BIOMARKERS OF IMMUNE TOLERANCE IN LIVER TRANSPLANTATION. Russian Journal of Transplantology and Artificial Organs. 2016;18(3):137-144. (In Russ.) https://doi.org/10.15825/1995-1191-2016-3-137-144

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ISSN 1995-1191 (Print)
ISSN 2412-6160 (Online)