БИОМАРКЕРЫ ИММУННОЙ ТОЛЕРАНТНОСТИ ПРИ ТРАНСПЛАНТАЦИИ ПЕЧЕНИ
Аннотация
Обзор литературы посвящен анализу исследований биомаркеров, позволяющих прогнозировать формирование иммунной толерантности и идентифицировать пациентов, которым можно безопасно минимизировать иммуносупрессию после трансплантации печени. В обзоре проанализированы 46 источников литературы, большая часть которых опубликована в последние пять лет. В настоящее время бурно развиваются новые технологии, позволяющие понять молекулярные механизмы нормальных, патологических и фармакологических процессов, протекающих при трансплантации органов. Однако до настоящего времени нет биомаркеров, валидированных для определения состояния иммунной толерантности и индивидуального подбора иммуносупрессантов. Накопление данных по пациентам вкупе с совершенствованием биоинформатики может значительно ускорить процесс развития подходов для стратификации пациентов.
Об авторах
О. П. Шевченко
ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России, Москва;
ГБОУ ВПО «Первый МГМУ имени И.М. Сеченова», Москва
Россия
Россия
Кафедра трансплантологии и искусственных органов
123182, Москва, ул. Щукинская, 1. Тел. (499) 190-38-77
Р. М. Курабекова
ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России, Москва
Россия
Россия
О. М. Цирульникова
ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России, Москва;
ГБОУ ВПО «Первый МГМУ имени И.М. Сеченова», Москва
Россия
Кафедра трансплантологии и искусственных органов
Россия
Кафедра трансплантологии и искусственных органов
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Рецензия
Для цитирования:
Шевченко О.П., Курабекова Р.М., Цирульникова О.М. БИОМАРКЕРЫ ИММУННОЙ ТОЛЕРАНТНОСТИ ПРИ ТРАНСПЛАНТАЦИИ ПЕЧЕНИ. Вестник трансплантологии и искусственных органов. 2016;18(3):137-144. https://doi.org/10.15825/1995-1191-2016-3-137-144
For citation:
Shevchenko O.P., Kurabekova R.M., Tsiroulnikova O.M. BIOMARKERS OF IMMUNE TOLERANCE IN LIVER TRANSPLANTATION. Russian Journal of Transplantology and Artificial Organs. 2016;18(3):137-144. (In Russ.) https://doi.org/10.15825/1995-1191-2016-3-137-144
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