ACUTE TACROLIMUS-INDUCED KIDNEY INSUFFICIENCY IN PATIENT AFTER HEART TRANSPLANTATION
https://doi.org/10.15825/1995-1191-2016-1-53-57
Abstract
In recent years the success of transplantation is associated primarily with extensive use of calcineurin inhibitors (CNIs) – cyclosporine and tacrolimus which became the basis of the various immunosuppressive therapy protocols. These drugs despite their effectiveness in the prevention of transplant rejection have serious side effects. Nephrosclerosis due to chronic nephrotoxic effect is recognized as the most important of them. But along with chronic nephrotoxic effects there are cases of acute kidney injury on the background of calcineurin inhibitors usage. The article presents a clinical case demonstrating the development of severe reversible nephropathy in a patient after heart transplantation receiving tacrolimus in standard dose.
About the Authors
D. V. Doronin
E.N. Meshalkin Novosibirsk State Research Institute of Circulation Pathology,
Ministry of Healthcare of the Russian Federation
Russian Federation
15, Rechkunovskaja str., Novosibirsk, 630055
Russian Federation
15, Rechkunovskaja str., Novosibirsk, 630055
A. M. Chernyavskiy
E.N. Meshalkin Novosibirsk State Research Institute of Circulation Pathology,
Ministry of Healthcare of the Russian Federation
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
A. V. Fomichev
E.N. Meshalkin Novosibirsk State Research Institute of Circulation Pathology,
Ministry of Healthcare of the Russian Federation
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
M. N. Deryagin
E.N. Meshalkin Novosibirsk State Research Institute of Circulation Pathology,
Ministry of Healthcare of the Russian Federation
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
V. N. Gorbatykh
E.N. Meshalkin Novosibirsk State Research Institute of Circulation Pathology,
Ministry of Healthcare of the Russian Federation
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
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Review
For citations:
Doronin D.V., Chernyavskiy A.M., Fomichev A.V., Deryagin M.N., Gorbatykh V.N. ACUTE TACROLIMUS-INDUCED KIDNEY INSUFFICIENCY IN PATIENT AFTER HEART TRANSPLANTATION. Russian Journal of Transplantology and Artificial Organs. 2016;18(1):53-57. (In Russ.) https://doi.org/10.15825/1995-1191-2016-1-53-57
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