ПУТИ РАСПОЗНАВАНИЯ ЧУЖЕРОДНЫХ АНТИГЕНОВ ПРИ АДАПТИВНОМ ИММУННОМ ОТВЕТЕ НА АЛЛОГЕННУЮ ТРАНСПЛАНТАЦИЮ ОРГАНОВ
https://doi.org/10.15825/1995-1191-2015-4-104-117
Аннотация
В основе реакции иммунологического отторжения аллогенного трансплантата лежит процесс распознавания донорских антигенов Т-клеточными рецепторами. В качестве антигенов, как правило, выступают молекулы главного комплекса гистосовместимости, экспрессированные клетками тканей донорского органа. По своей активности иммунный ответ на аллогенный трансплантат в значительной степени превышает реакцию на обычную инфекцию и характеризуется стойкой иммунологической памятью. При этом базовые механизмы распознавания антигена при инфекции и аллотрансплантации, по-видимому, должны быть сходными. В данном обзоре рассматриваются три основных пути распознавания аллоантигенов, принципиально различающиеся природой антигенпрезентирующих клеток, кинетикой и продолжительностью своего влияния на формирование аллоиммунитета: прямой, непрямой и смешанный. Установление взаимосвязи механизмов аллораспознавания с проявлениями реакции отторжения трансплантата имеет важное клиническое значение.
Об авторах
А. С. Беркос
ФГБУ «Российский НИИ гематологии и трансфузиологии ФМБА России», Санкт-Петербург, Российская Федерация
Россия
Россия
Г. В. Николаев
ФГБУ «Северо-Западный федеральный медицинский исследовательский центр» Минздрава России, Санкт-Петербург, Российская Федерация
Россия
Россия
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Рецензия
Для цитирования:
Беркос А.С., Николаев Г.В. ПУТИ РАСПОЗНАВАНИЯ ЧУЖЕРОДНЫХ АНТИГЕНОВ ПРИ АДАПТИВНОМ ИММУННОМ ОТВЕТЕ НА АЛЛОГЕННУЮ ТРАНСПЛАНТАЦИЮ ОРГАНОВ. Вестник трансплантологии и искусственных органов. 2015;17(4):104-117. https://doi.org/10.15825/1995-1191-2015-4-104-117
For citation:
Berkos A.S., Nikolaev G.V. PATHWAYS OF RECOGNITION OF FOREIGN ANTIGENS IN THE ADAPTIVE IMMUNE RESPONSE TO ALLOGENEIC ORGAN TRANSPLANTATION. Russian Journal of Transplantology and Artificial Organs. 2015;17(4):104-117. (In Russ.) https://doi.org/10.15825/1995-1191-2015-4-104-117
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