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ТРАНСФОРМИРУЮЩИЙ ФАКТОР РОСТА 1 ПРИ ТРАНСПЛАНТАЦИИ ПЕЧЕНИ

https://doi.org/10.15825/1995-1191-2015-3-76-82

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Аннотация

Обзор литературы посвящен анализу роли трансформирующего фактор роста бета 1 (TGF-β1) при трансплантации печени. TGF-β1 играет ключевую роль в развитии фиброза печени, а также в развитии иммунного ответа; его концентрация в ткани и в крови изменяется при заболеваниях печени. Уровень TGF-β1 в крови реципиентов печени связан с развитием фиброза, формированием иммунной толерантности и иммунным ответом на активную инфекцию. Измерение уровня TGF-β1 при трансплантации печени может иметь диагностическое и прогностическое значение при оценке состояния трансплантата. В настоящее время клинических данных о роли цитокина при трансплантации печени накоплено недостаточно, и необходимы дальнейшие исследования связи уровня TGF-β1 с различными клиническими и лабораторными показателями у реципиентов печени. В обзоре проанализированы 54 источника литературы, более половины из которых опубликованы в последние пять лет.

Об авторах

Р. М. Курабекова
ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России, Москва, Российская Федерация
Россия


О. П. Шевченко
ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России, Москва, Российская Федерация Кафедра трансплантологии и искусственных органов ГБОУ ВПО «Первый МГМУ им. И.М. Сеченова», Москва, Российская Федерация
Россия

123182, г. Москва, ул. Щукинская, д. 1. Тел. (499) 190-38-77



О. М. Цирульникова
ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России, Москва, Российская Федерация Кафедра трансплантологии и искусственных органов ГБОУ ВПО «Первый МГМУ им. И.М. Сеченова», Москва, Российская Федерация
Россия


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Для цитирования:


Курабекова Р.М., Шевченко О.П., Цирульникова О.М. ТРАНСФОРМИРУЮЩИЙ ФАКТОР РОСТА 1 ПРИ ТРАНСПЛАНТАЦИИ ПЕЧЕНИ. Вестник трансплантологии и искусственных органов. 2015;17(3):76-82. https://doi.org/10.15825/1995-1191-2015-3-76-82

For citation:


Kurabekova R.M., Shevchenko O.P., Tsiroulnikova O.M. TRANSFORMING GROWTH FACTOR 1 AT LIVER TRANSPLANTATION. Russian Journal of Transplantology and Artificial Organs. 2015;17(3):76-82. (In Russ.) https://doi.org/10.15825/1995-1191-2015-3-76-82

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ISSN 1995-1191 (Print)
ISSN 2412-6160 (Online)