ЭТИОЛОГИЯ, ПАТОГЕНЕЗ И МОРФОЛОГИЯ ЭФФЕКТА QUILTY
Аннотация
Несмотря на то что изучение эндокардиальных инфильтратов (Quilty effect) в трансплантированном сердце продолжается уже более 30 лет, этиология, морфология и клиническое значение этого феномена остаются до конца не выясненными. В статье приведены данные доступной литературы о возможных причинах и механизмах развития эффекта Quilty, а также о его влиянии на функцию трансплантированного сердца.
Об авторах
Л. С. Алексеева
ФГБУ «ФНЦ трансплантологии и искусственных органов имени академика В.И. Шумакова»
Минздрава России, г. Москва
Россия
123182, г. Москва, ул. Щукинская, д. 1. Тел. 8 (968) 803-12-69
Россия
123182, г. Москва, ул. Щукинская, д. 1. Тел. 8 (968) 803-12-69
И. М. Ильинский
ФГБУ «ФНЦ трансплантологии и искусственных органов имени академика В.И. Шумакова»
Минздрава России, г. Москва
Кафедра трансплантологии и искусственных органов I МГМУ имени И.М. Сеченова, г. Москва
Россия
Россия
Список литературы
1. Mohacsi PJ, Joshi A, Wang J, Morris RE, Billingham ME. Endocardial mononuclear cell infi ltrates (Quilty effect) in heterotopic cardiac allografts in rapamycin-treated rats. Transplant Proc. 1994 Dec; 26 (6): 3255–3259.
2. Gopal S, Narasimhan U, Day JD, Gao R, Kasper EK, Chen CL et al. The Quilty lesion enigma: focal apoptosis/necrosis and lymphocyte subsets in human cardiac allografts. Pathol Int. 1998 Mar; 48 (3): 191–198.
3. Duquesnoy RJ, Liu K, Fu XF, Murase N, Ye Q, Demetris cardiac allograft model of chronic rejection. Transplantation. 1999 Jan 15; 67 (1): 156–164.
4. Kottke-Marchant K, Ratliff NB. Endomyocardial lymphocytic infi ltrates in cardiac transplant recipients. Incidence and characterization. Arch Pathol Lab Med. 1989 Jun; 113 (6): 690–698.
5. Pardo-Mindán FJ1, Lozano MD. «Quilty effect» in heart transplantation: is it related to acute rejection? J Heart Lung Transplant. 1991 Nov-Dec; 10 (6): 937–941.
6. Costanzo-Nordin MR, Winters GL, Fisher SG, O'Sullivan J, Heroux AL, Kao W et al. Endocardial infiltrates in the transplanted heart: clinical signifi cance emerging from the analysis of 5026 endomyocardial biopsy specimens. J Heart Lung Transplant. 1993 Sep-Oct; 12 (5): 741–747.
7. Joshi A, Masek MA, Brown BW Jr, Weiss LM, Billingham ME. «Quilty» revisited: a 10-year perspective. Hum Pathol. 1995 May; 26 (5): 547–557.
8. Yamani MH, Ratliff NB, Starling RC, Tuzcu EM, Yu Y, Cook DJ et al. Quilty lesions are associated with increased expression of vitronectin receptor (alphavbeta3) and subsequent development of coronary vasculopathy. J Heart Lung Transplant. 2003 Jun; 22 (6): 687–690.
9. Di Carlo E, D'Antuono T, Contento S, Di Nicola M, Ballone E, Sorrentino C. Quilty effect has the features of lymphoid neogenesis and shares CXCL13-CXCR5 pathway with recurrent acute cardiac rejections. Am J Transplant. 2007 Jan; 7 (1): 201–210.
10. Hiemann NE, Knosalla C, Wellnhofer E, Lehmkuhl HB, Hetzer R, Meyer R. Quilty indicates increased risk for microvasculopathy and poor survival after heart transplantation. J Heart Lung Transplant. 2008 Mar; 27 (3):289–296.
11. Zakliczynski M, Nozynski J, Konecka-Mrowka D, Pyka L, Trybunia D, Swierad M et al. Quilty effect correlates with biopsy-proven acute cellular rejection but does not predict transplanted heart coronary artery vasculopathy. J Heart Lung Transplant. 2009 Mar; 28 (3): 255–259.
12. Chu KE, Ho EK, de la Torre L, Vasilescu ER, Marboe CC. The relationship of nodular endocardial infi ltrates (Quilty lesions) to survival, patient age, anti-HLA antibodies, and coronary artery disease following heart transplantation. Cardiovasc Pathol. 2005 Jul-Aug; 14 (4): 219–224.
13. Plaza DM, Fernandez D, Builes M, Villegas A, Garcнa LF. Cytokine gene polymorphisms in heart transplantation: association of low IL-10 production genotype with Quilty effect. J Heart Lung Transplant. 2003 Aug; 22 (8): 851–856.
14. Beletskaya LV, Kupriyanova AG, Baranova FS, Shumakov VI. Heart allograft lymphatic system changes and Quilty lesion. J Heart Lung Transplant. 2005 Nov; 24 (11): 1999–2000.
15. Gajjar NA, Kobashigawa JA, Laks H, Espejo-Vassilakis M, Fishbein MC. FK506 vs. cyclosporin. Pathologic fi ndings in 1067 endomyocardial biopsies. Cardiovasc Pathol. 2003 Mar-Apr; 12 (2): 73–76.
16. Forbes RD, Rowan RA, Billingham ME. Endocardial infi ltrates in human heart transplants: a serial biopsy analysis comparing four immunosuppression protocols. Hum Pathol. 1990 Aug; 21 (8): 850–855.
17. Smith RN, Chang Y, Houser S, Dec GW, Grazette L. Higher frequency of high-grade rejections in cardiac allograft patients after Quilty B lesions or grade 2/4 rejections. Transplantation. 2002 Jun 27; 73 (12): 1928–1932.
18. Radio SJ, McManus BM, Winters GL, Kendall TJ, Wilson JE, Costanzo-Nordin MR et al. Preferential endocardial residence of B-cells in the «Quilty effect» of human heart allografts: immunohistochemical distinction from rejection. Mod Pathol. 1991 Sep; 4 (5): 654–660.
19. Barone JH, Fishbein MC, Czer LS, Blanche C, Trento A, Luthringer DJ. Absence of endocardial lymphoid infi ltrates (Quilty lesions) in nonheart transplant recipients treated with cyclosporine. J Heart Lung Transplant. 1997 Jun; 16 (6): 600–603.
20. Freimark D, Czer LS, Aleksic I, Ruan XM, Admon D, Blanche C et al. Pathogenesis of Quilty lesion in cardiac allografts: relationship to reduced endocardial cyclosporine A. J Heart Lung Transplant. 1995 Nov-Dec; 14 (6 Pt 1): 1197–1203.
21. Kemnitz J, Cremer J, Schaefers HJ, Restrepo-Specht I, Haverich A, Uysal A et al. Some aspects of changed histopathologic appearance of acute rejection in cardiac allografts after prophylactic application of OKT3. J Heart Lung Transplant. 1991 May-Jun; 10 (3): 366–372.
22. Hiemann NE, Hetzer R, Meyer R. Quilty effect, acute cellular rejection, and transplant vasculopathy: still controversial. J Heart Lung Transplant. 2009 Nov; 28 (11): 1240.
23. Fishbein MC, Bell G, Lones MA, Czer LS, Miller JM, Harasty D et al. Grade 2 cellular heart rejection: does it exist? J Heart Lung Transplant. 1994 Nov-Dec; 13 (6): 1051–1057.
24. Marboe CC, Billingham M, Eisen H, Deng MC, Baron H, Mehra M et al. Nodular endocardial infi ltrates (Quilty lesions) cause signifi cant variability in diagnosis of ISHLT Grade 2 and 3A rejection in cardiac allograft recipients. J Heart Lung Transplant. 2005 Jul; 24 (7 Suppl): S219–226.
25. Clelland C, Fielding S, Storie I, Kennedy A, Smith G, Locke T. A comparison of the cytology of endomyocardial biopsy washings from heart transplants with biopsy histologic study and peripheral blood lymphocyte counts. J Heart Lung Transplant. 1997 May; 16 (5): 477–483.
26. Cano LC, Arteta AA, Fernandez R, Garcna-Asenjo JA, Hernandez S, Fernandez D et al. Quilty effect areas are frequently associated with endocardial C4d deposition. J Heart Lung Transplant. 2008 Jul; 27 (7): 775–779.
27. Luthringer DJ, Yamashita JT, Czer LS, Trento A, Fishbein MC. Nature and signifi cance of epicardial lymphoid infi ltrates in cardiac allografts. J Heart Lung Transplant. 1995 May-Jun; 14 (3): 537–543.
28. Hiemann NE, Knosalla C, Wellnhofer E, Lehmkuhl HB, Hetzer R, Meyer R. Quilty in biopsy is associated with poor prognosis after heart transplantation. Transpl Immunol. 2008 Jul; 19 (3–4): 209–214.
29. Stewart S, Winters GL, Fishbein MC, Tazelaar HD, Kobashigawa J, Abrams J et al. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant. 2005 Nov; 24 (11): 1710–1720.
30. Michaels PJ, Kobashigawa J, Laks H, Azarbal A, Espejo ML, Chen L et al. Differential expression of RANTES chemokine, TGF-beta, and leukocyte phenotype in acute cellular rejection and quilty B lesions. J Heart Lung Transplant. 2001 Apr; 20 (4): 407–416.
31. Sattar HA, Husain AN, Kim AY, Krausz T. The presence of a CD21+ follicular dendritic cell network distinguishes invasive Quilty lesions from cardiac acute cellular rejection. Am J Surg Pathol. 2006 Aug; 30 (8): 1008–1013.
32. Jonigk D, Lehmann U, Stuht S, Wilhelmi M, Haverich A, Kreipe H et al. Recipient-derived neoangiogenesis of arterioles and lymphatics in quilty lesions of cardiac allografts. Transplantation. 2007 Nov 27; 84 (10): 1335– 1342.
33. Laguens RP, Meckert PM, Martino JS, Perrone S, Favaloro R. Identifi cation of programmed cell death (apoptosis) in situ by means of specifi c labeling of nuclear DNA fragments in heart biopsy samples during acute rejection episodes. J Heart Lung Transplant. 1996 Sep; 15 (9): 911–918.
34. Jollow KC, Sundstrom JB, Gravanis MB, Kanter K, Herskowitz A, Ansari AA. Apoptosis of mononuclear cell infi ltrates in cardiac allograft biopsy specimens questions studies of biopsy-cultured cells. Transplantation. 1997 May 27; 63 (10): 1482–1489.
35. Dong C, Winters GL, Wilson JE, McManus BM. Enhanced lymphocyte longevity and absence of proliferation and lymphocyte apoptosis in Quilty effects of human heart allografts. Am J Pathol. 1997 Jul; 151 (1): 121–130.
36. Truell JS, Fishbein MC. Case report of a Quilty lesion within a coronary artery. Cardiovasc Pathol. 2006 May-Jun; 15 (3): 161–164.
Для цитирования:
Алексеева Л.С., Ильинский И.М. ЭТИОЛОГИЯ, ПАТОГЕНЕЗ И МОРФОЛОГИЯ ЭФФЕКТА QUILTY. Вестник трансплантологии и искусственных органов. 2014;16(4):117-124. https://doi.org/10.15825/1995-1191-2014-4-117-124
For citation:
Alexeeva L.S., Iljinsky I.M. ETIOLOGY, PATHOGENESIS AND MORPHOLOGY OF THE QUILTY EFFECT. Russian Journal of Transplantology and Artificial Organs. 2014;16(4):117-124. (In Russ.) https://doi.org/10.15825/1995-1191-2014-4-117-124
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