PREGNANCY-ASSOCIATED PLASMA PROTEIN A (PAPP-A) IN CARDIAC ALLOGRAFT VASCULOPATHY
https://doi.org/10.15825/1995-1191-2011-2-46-51
Abstract
Cardiac allograft vasculopathy (CAV) remains to be one of the most serious complications after heart trans- plantation (HTx) and a main cause of death in patients survived the first year after transplantation. Pregnancy- associated plasma protein A (PAPP-A), a potentially proatherosclerotic zinc binding metalloproteinase, has been shown to be elevated in ischemic heart disease patients and heart transplant recipient. The aim of the study was to evaluate the relationship between РАРР-A plasma levels and the extent of coronary lesions in heart transplant recipients. The study included 37 heart transplant recipients. CAV was diagnosed in 23 recipients. Our results showed that PAPP-A plasma levels were higher in recipients with CAV, did not correlate with the duration of time after HTx but were associated with the extent of coronary lesion.
About the Authors
О. P. Shevchenko
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
O. V. Orlova
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
E. N. Kazakov
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
A. Y. Kormer
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
V. V. Chestukhin
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
B. L. Mironkov
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
A. V. Bugrov
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Shevchenko О.P., Orlova O.V., Kazakov E.N., Kormer A.Y., Chestukhin V.V., Mironkov B.L., Bugrov A.V. PREGNANCY-ASSOCIATED PLASMA PROTEIN A (PAPP-A) IN CARDIAC ALLOGRAFT VASCULOPATHY. Russian Journal of Transplantology and Artificial Organs. 2011;13(2):46-51. (In Russ.) https://doi.org/10.15825/1995-1191-2011-2-46-51
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