ПРИНЦИПЫ ИНТЕНСИВНОЙ ТЕРАПИИ ДОНОРА СО СМЕРТЬЮ МОЗГА
https://doi.org/10.15825/1995-1191-2010-4-72-79
Аннотация
Ведение потенциального донора со смертью мозга – один из важнейших моментов в органном донор- стве. В мире накоплен большой практический опыт ведения потенциального донора, но нет единого мнения о многих принципиальных моментах. В статье представлен обзор современных представлений о патофизиологии смерти мозга, клинических ее проявлениях и основных принципах ведения донора. Анестезиолог-реаниматолог является ключевой фигурой в подготовке донора к эксплантации, и если ка- чество этого процесса улучшится, увеличится количество донорских органов и выживание реципиентов.
Об авторах
С. К. Сергиенко
ГУ «Санкт-Петербургский научно-исследовательский институт скорой помощи им. И.И. Джанелидзе»
Россия
Россия
О. Н. Резник
ГУ «Санкт-Петербургский научно-исследовательский институт скорой помощи им. И.И. Джанелидзе»
Россия
Россия
А. А. Пустовалов
ГУ «Санкт-Петербургский научно-исследовательский институт скорой помощи им. И.И. Джанелидзе»
Россия
Россия
И. В. Логинов
ГУ «Санкт-Петербургский научно-исследовательский институт скорой помощи им. И.И. Джанелидзе»
Россия
Россия
Список литературы
1. Козлов И.А., Сазонцева И.Е., Мойсюк Я.Г., Ермо- ленко А.Е., Ильницкий В.В. Нейроэндокринные рас- стройства у доноров со смертью мозга во время опе- раций мультиорганного забора // Анестезиология и реаниматология. 1992. No 1. С. 52–56.
2. Arbour R. Clinical management of the organ donor // AACN Clin Issues. 2005. Vol. 16. P. 551–580.
3. Barklin A. Systemic inflammation in the brain-dead or- gan donor // Acta Anaesthesiol Scand. 2009. Vol. 53. P. 425–435.
4. Chamorro C., Silva J.A., Romera M.A. Cardiac donor management: another point of view // Transplant Proc. 2003. Vol. 35. P. 1935–1937.
5. Cohen J., Chernov K., Ben-Shimon O., Singer P. Man- agement of the brain-dead, heart-beating potential do- nor // Isr. Med. Assoc. J. 2002. Vol. 4. P. 243–246.
6. Cooper D.K., Novitzky D., Wicomb W.N. The pathophy- siological effects of brain death on potential donor or- gans, with particular reference to the heart // Annals of the Royal College of Surgeons of England. 1989. Vol. 71. P. 261–266.
7. Cooper D.K., Novitzky D., Wicomb W.N. et al. A review of studies relating to thyroid hormone therapy in brain- dead organ donors // Front Biosci. 2009. Jan 1. Vol. 14. P. 3750–3770.
8. Debaveye Y.A., Van den Berghe G.H. Is there still a place for dopamine in the modern intensive care unit? // An- esth. Analg. 2004. Vol. 98. P. 461–468.
9. Dictus C., Vienenkoetter B., Esmaeilzadeh M., Unter- berg A., Ahmadi R. Critical care management of potential organ donors: our current standard // Clin. Transplant. 2009. Vol. 23 (Suppl. 21). P. 2–9.
10. DuBose J., Salim A. Aggressive Organ Donor Manage- ment Protocol // Journal of Intensive Care Medicine. 2008. Vol. 23. P. 367–375.
11. Fitzgerald R.D., Hieber C., Schweitzer E. et al. Intraope- rative catecholamine release in brain-dead organ donors is not suppressed by administration of fentanyl // Eur. J. Anaesthesiol. 2003. Vol. 20. P. 952–956.
12. Hevesi Z.G., Lopukhin S.Y., Angelini G., Coursin D.B. Supportive care after brain death for the donor candi- date // Int. Anesthesiol. Clin. 2006. Vol. 44 (3). P. 21–34.
13. Hing A., Hicks M., Gao L. et al. The case for a standard- ised protocol that includes hormone resuscitation for the management of the cadaveric multi-organ donor // Criti- cal Care and Resuscitation. 2005. Vol. 7. P. 43–50.
14. Gasser M., Waaga A.M., Laskowski I.A., Tilney N.L. Or- gan transplantation from brain-dead donors: its impact on short- and long-term outcome revisited // Transplan- lalion Reviews. 2001. Vol. 15. P. 1–10.
15. Gelb A.W., Robertson K.R. Anaesthetic management of the brain dead for organ donation // Can. J. Anaesth. 1990. Vol. 37. P. 806–812.
16. Kutsogiannis D.J., Pagliarello G., Doig C., Ross H., Shemie S.D. Medical management to optimize donor or- gan potential: review of the literature // Can. J. Anaesth. 2006. Vol. 53. P. 820–830.
17. Lopez-Navidad A., Caballero F. For a rational approach to the critical points of the cadaveric donation process // Transplant Proc. 2001. Vol. 33. P. 795–805.
18. MacLean A., Dunning J. The retrival of thoracic organs: donor assessment and management // British Medical Bulletin. 1997. Vol. 53. P. 829–843.
19. Marik P.E., Mohedin M. The contrasting effects of dopamine and norepinephrine on systemic and splanchnicn oxygen utilization in hyperdynamic sepsis // JAMA.
20. Vol. 272. P. 1354–1357.
21. Martin C., Viviand X., Leone M., Thirion X. Effect of
22. norepinephrine on the outcome of septic shock // Crit
23. Care Med. 2000. Vol. 28. P. 2758–2765.
24. Mascia L., Mastromauro I., Viberti S., Vincenzi M.,
25. Zanello M. Management to optimize organ procurement in brain dead donors // Minerva Anestesiol. 2009 Mar. Vol. 75. P. 125–133.
26. Medical management to optimize donor organ potential: A Canadian Forum // Report and recommendations. Feb- ruary 23–25, 2004. Mont Tremblant, Quebec.
27. Novitzky D., Horak A., Cooper D.K., Rose A.G. Electro- cardiographic and histopathologic changes developing during experimental brain death in the baboon // Trans- plant Proc. 1989. Vol. 21. P. 2567–2569.
28. Nygaard C.E., Townsend R.N., Diamond D.L. Organ donor management and organ outcome: a 6-year review from a Level I trauma center // J. Trauma. 1990. Vol. 30. P. 728–732.
29. Phongsamran P.V. Critical care pharmacy in donor man- agement // Prog. Transplantation. 2004. Vol. 14 (2). P. 105–113.
30. Powner D.J. Donor care before pancreatic tissue trans- plantation // Prog. Transplant. 2005. Vol. 15. P. 129– 136.
31. Powner D.J. Aggressive donor care–to what end? // In- tensive Care Med. 2008. Vol. 23. P. 409–411.
32. Powner D.J., Darby J.M. Management of variations in blood pressure during care of organ donors // Prog. Transplant. 2000. Vol. 10. P. 25–30.
33. Powner D.J., Darby J.M., Kellum J.A. Proposed treat- ment guidelines for donor care // Prog. Transplant. 2004. Vol. 14. P. 16–26.
34. Powner D.J., Hernandez M. A review of thyroid hor- mone administration during adult donor care // Prog. Transplant. 2005. Vol. 15. P. 202–207.
35. Powner D.J., Kellum J.A. Maintaining acid-base balance in organ donors // Prog. Transplant. 2000. Vol. 10. P. 98– 105.
36. Powner D.J., Kellum J.A., Darby J.M. Abnormalities in fluids, electrolytes, and metabolism of organ donors // Prog. Transplant. 2000. Vol. 10. P. 88–94.
37. Powner D.J., Reich H.S. Regulation of coagulation ab- normalities and temperature in organ donors // Prog. Transplant. 2000. Vol. 10. P. 146–151.
38. Pratschke J., Neuhaus P., Tullius S.G. What can be learned from brain-death models? // Transplant Interna- tional. 2005. Vol. 18. P. 15–21.
39. Ramos H.C., Lopez R. Critical care management of the. brain-dead organ donor // Curr Opin Organ Transplant. 2002. Vol. 7. P. 70–75.
40. Rosendale J.D., Chabalewski F.L., McBride M.A. In- creased transplanted organs from the use of a standard- ized donor management protocol // Am. J. Transplant. 2002. Vol. 2. P. 761–768.
41. Salim A., Martin M., Brown C. et al. Complications of brain death: frequency and impact on organ retrieval // Am Surg. 2006. Vol. 72. P. 377–381.
42. Salim A., Vassiliu P., Velmahos G.C. et al. The role of thyroid hormone administration in potential organ do- nors // Arch Surg. 2001. Vol. 136. P. 1377–1380.
43. Saner F.H., Kavuk I., Lang H. et al. Organ protective ma- nagement of the brain-dead donor // Eur. J. Med. Res. 2004. Vol. 9. P. 485–490.
44. Schnuelle P., Berger S., de Boer J. et al. Effects of cate- cholamine application to brain-dead donors on graft sur- vival in solid organ transplantation // Transplantation. 2001. Vol. 72. P. 455–463.
45. Shah V.R. Aggressive Management of Multiorgan Do- nor // Transplant Proc. 2008. Vol. 40. P. 1087–1090.
46. Shemie S.D., Ross H., Pagliarello J. et al. Organ do-
47. nor management in Canada: recommendations of the forum on Medical Management to Optimize Donor Or- gan Potential // Can. Med. Assoc. J. 2006. Vol. 174 (6). P. 13–32.
48. Shivalkar B., Van Loon J., Wieland W. et al. Variable effects of explosive or gradual increase of intracranial pressure on myocardial structure and function // Circula- tion. 1993. Vol. 87. P. 230–239.
49. Sinner B., Graf B.M. Anaesthesie zur Organentnahme [Anaesthesia for organ explantation] // Der Anaesthesist. 2002. Vol. 51. P. 493–511.
50. Smith M. Physiologic Changes During Brain Stem Death–Lessons for Management of the Organ Donor // J. Heart Lung Transplant. 2004. Vol. 23. S. 217–222.
51. Stocker R., Burgi U., Rohling R. Intensive care of the multiorgan donor // Eur. J. Trauma. 2000. Vol. 26. P. 53–61.
52. Tuttle-Newhall J.E., Collins B.H., Kuo P.C. et al. Organ donation and treatment of the multiorgan donor // Curr. Prob. Surg. 2003. Vol. 40 (5). P. 253–310.
53. Ullah S., Zabala L., Watkins B., Schmitz M.L. Cardiac organ donor management // Perfusion. 2006. Vol. 21. P. 93–98.
54. Venkataraman R., Song M., Lynas R., Kellum J.A. He- moadsorption to improve organ recovery from brain- dead organ donors: a novel therapy for a novel indica- tion? // Blood Purif. 2004. Vol. 22. P. 143–149.
55. Venkateswaran R.V., Patchell V.B., Wilson I.C. et al. Ear- ly donor management increases the retrieval rate of lungs for transplantation // Ann Thorac Surg. 2008. Vol. 85. P. 278–286.
56. Venkateswaran R.V., Steeds R.P., Quinn D.W. et al. The haemodynamic effects of adjunctive hormone therapy in potential heart donors: a prospective randomized double- blind factorially designed controlled trial // Eur Heart J. 2009. Vol. 30. P. 1771–1780.
57. Vroom M.B. An overview of inotropic agents // Semin Cardiothorac Vasc Anesth. 2006. Vol. 10. P. 246–252.
58. Wheeldon D.R., Potter C.D., Oduro A., Wallwork J., Large S.R. Transforming the «unacceptable» donor: out- comes from the adoption of a standardized donor ma- nagement technique // J. Heart Lung Transplant. 1995 Jul-Aug. Vol. 14 (4). P. 734–742.
59. Wood K.E., Becker B.N., McCartney J.G., D’Alessand- ro A.M., Coursin D.B. Care of the potential organ donor // Engl. J. Med. 2004. Vol. 351. P. 2730–2739.
60. Wood K.E., Coursin D.B. Intensivists and organ do- nor management // Current opinion in anaesthesiology. 2007. Vol. 20. P. 97–99.
61. Zaroff J.G., Rosengard B.R., Armstrong W.F. et al. Con- sensus conference report: maximizing use of organs re- covered from the cadaver donor // Cardiac recommendations, March 28–29, 2001, Crystal City, Va. Circulation. 2002. Vol. 106. P. 836–841.
62. Young P.J., Matta B.F. Anaesthesia for organ donation in the brainstem dead-why bother? // Anaesthesia. 2000. Vol. 55. P. 105–106.
Рецензия
Для цитирования:
Сергиенко С.К., Резник О.Н., Пустовалов А.А., Логинов И.В. ПРИНЦИПЫ ИНТЕНСИВНОЙ ТЕРАПИИ ДОНОРА СО СМЕРТЬЮ МОЗГА. Вестник трансплантологии и искусственных органов. 2010;12(4):72-79. https://doi.org/10.15825/1995-1191-2010-4-72-79
For citation:
Sergienko S.K., Reznik O.N., Pustovalov A.A., Loginov I.V. PRINCIPLES OF INTENSIVE CARE OF BRAIN DEATH DONOR. Russian Journal of Transplantology and Artificial Organs. 2010;12(4):72-79. (In Russ.) https://doi.org/10.15825/1995-1191-2010-4-72-79
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