ROLE OF NUCLEAR FACTOR NF-κB IN ALLOGRAFT REJEKTION
https://doi.org/10.15825/1995-1191-2010-1-72-77
Abstract
Nuclear factor kappa B (NF-κB) is a rapid response transcription factor for genes whose products are critical for inflammation and immunity. In this review structure and general properties of NF-κB the role of transcription factor NF-κB in allograft rejection are presented. In this review considered the mechanism activation of NF-κB in allograft rejection and its role in following pathological processes: endothelial cells activation, recipient T-cells activation and maturation of dendritic cells (antigen – presenting immune cells). NF-κB – targeted therapeutics approaches, that might be effective in transplantation are presented.
About the Author
N. V. Kuncevich
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
References
1. Sen R., Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequence // Cell. 1986. Vol. 80. P. 321–330.
2. Li Q., Verma I.M. NF-κB regulation in the immune sys- tem // Nat. Rev. Immunol. 2002. Vol. 2. P. 925–934.
3. Karin M., Lin A. NF-κB at the cross roads of life and
4. death // Nat. Immunol. 2002. Vol. 3. P. 221–227.
5. Baeuerle P.A., Baltimere D. NF-κB: Ten years after. Cell.
6. Vol. 87. P. 13–20.
7. Lopez F.O., Suzuki Y., Sanjuan G. et al. Nuclear factor-
8. κB inhibitors as potential novel anti-inflammatory agents for the treatment of immune glomerulonephritis // Am J. Pathol. 2002. Vol. 161. P. 1497–1505.
9. Ghosh S., May M., Kopp E. NF-κB and Rel proteins: evolutionarily conserved mediators of the immune re- sponse // Ann Rev. Immunol. 1998. Vol. 16. P. 225–260.
10. Thanos D., Maniatis T. NF-κB: a lesson in family va- lues // Cell. 1995. Vol. 80. P. 529–532.
11. Ben-Neriah Y. Regulatory functions of ubiquitination in the immune system // Nat. Immunol. 2002. Vol. 3. P. 20–26.
12. Barnes P.J., Karin M. Nuclear factor-κB: a pivotal tran- scription factor in chronic inflammatory diseases // N. Eng. J. Med. 1997. Vol. 336. P. 1066–1071.
13. May M.J., Sankar G. Signal transduction through NF- κB // Immunol. Today. 1998. Vol. 19. P. 80–88.
14. Solez K., Racusen L.C., Abdulkareem F. et al. Adhesion molecules and rejection of renal allograft // Kidney Int. 1997. Vol. 51. P. 1476–1480.
15. Feeley B.T., Miniati D.N., Park A.K. et al. Nuclear fac- tor-kappa B transcription factor decoy treatment inhibits graft coronary artery disease after cardiac transplanta- tion in rodents // Transplantation. 2000. Vol. 70. P. 1560– 1568.
16. Vos I.H., Govers R., Grone H.J. et al. NF-κB decoy oli- godexynucleotides reduce monocyte infiltration in renal allografts // FASEB J. 2000. Vol. 14. P. 815–822.
17. Brand K., Page S., Walli A.K. et al. Role of nuclear fac- tor-κB in atherogenesis // Exp. Physiol. 1997. Vol. 82. P. 297–304.
18. Janssen-Heininger Y.M., Poynter M.E., Baeuerle P.A. Recent advances towards understanding redox mecha- nisms in the activation of nuclear factor-κB // Free Ra- dic. Biol. Med. 2000. Vol. 28. P. 1317–1327.
19. Haddad J.J. Redox regulation of pro-inflammatory cy- tokines and IκB-alpha/NF-κB nuclear translocation and activation // Biochem. Biophy Res. Commun. 2002. Vol. 296. P. 847–856.
20. Russell M.E., Wallace A.F., Hancock W. et al. Up-regula- tion of cytokines associated with macrophage activation in the Lewis-to-F344 rat transplantation model of chro- nic cardiac rejection // Transplantation 1995. Vol. 59. P. 572–578.
21. Sakurai H., Hisada Y., Ueno M. et al. Activation of tran- scription factor NF-κB in experimental glomerulonephri- tis in rats // Biochim. Biophys. Acta. 1996. Vol. 1316. P. 132–138.
22. Azuma H., Tomita N., Kaneda Y. et al. Transfection of NF-κB-decoy oligodeoxynucleotides using efficient ul- trasound mediated gene transfer into donor kidneys pro- longed survival of rat renal allografts // Gene Ther. 2003. Vol. 10. P. 415–425.
23. Alcalde G., Merino J., Sanz S. et al. Circulating adhesion molecules during kidney allograft rejection // Transplan- tation. 1995. Vol. 59. P. 1695–1699.
24. Albert S., Baldwin Jr. Series introduction: the transcrip- tion factor NF-κB and human disease // J. Clin. Invest. 2001. Vol. 107. P. 1024.
25. Meldrum D.R. Tumor necrosis factor in the heart // Am J. Physiol. 1998. Vol. 274. P. R577–R595.
26. Finn P.W., Stone J.R., Boothby M.R. et al. Inhibition of NF-κB-dependent T-cell activation abrogates acute allo- graft rejection // J. Immunol. 2001. Vol. 167. P. 245–252.
27. Thomson A.W., Lu L. Dendritic cells as regulators of immune reactivity: implications for transplantation // Transplantation. 1999. Vol. 68. P. 1–8.
28. Lu L., Mc Caslin D., Starzl T.E. et al. Bone marrow-de- rived dendritic cell progenitors induce alloantigen-spe- cific hyporesponsiveness in murine T-lymphocytes // Transplantation. 1995. Vol. 60. P. 1539–1545.
29. Lu L., Bonham C.A., Chambers F.G. et al. Induction of nitric oxide synthase in mouse dendritic cells by IFN-gamma, endotoxin, and interaction with alloge- neic T-cells: Nitric oxide production is associated with dendritic cell apoptosis // J. Immunol. 1996. Vol. 157. P. 3577 –3586.
30. Rescigno M., Martino M., Sutherland C.L. et al. Den- dritic cell survival and maturation are regulated by dif- ferent signaling pathways // J. Exp. Med. 1998. Vol. 188. P. 2175–2180.
31. Lu L., Thomson A.W. Manipulation of dendritic cells for tolerance induction in transplantation and autoimmune disease // Transplantation. 2002. Vol. 73. P. S19–22.
32. Potoka D.A., Nadler E.P., Zhou X. et al. Inhibition of NF-κB by IκB prevents cytokine-induced NO produc- tion and promotes enterocyte apoptosis in vitro // Shock. 2000. Vol. 14. P. 366–373.
33. Lee J.I., Ganster R.W., Geller D.A. et al. Cyclosporine A inhibits the expression of costimulatory molecules on in vitro generated dendritic cells: association with redu- ced nuclear translocation of nuclear factor-κB // Trans- plantation. 1999. Vol. 68. P. 1255–1263.
34. Giannoukakis N., Bonham A., Qian S.G. et al. Prolon- gation of cardiac allograft survival using dendritic cells treated with NF-κB decoy oligodeoxyribonucleotides // Molecular Therapy. 2000. Vol. 1. P. 430–437.
35. Yamamoto Y., Gaynor R.B. Therapeutic potential of in- hibition of the NF-κB pathway in the treatment of in- flammation and cancer // J. Clin. Invest. 2001. Vol. 107. P. 135–142.
36. Sheri M.F., Jeffrey S.C., Laura S.G. et al. A D-amino acid peptide inhibitor of NF-κB nuclear localization if effica- cious in, odels of inflammatory disease // J. Immunol. 2000. Vol. 165. P. 10 004–10 012.
37. Verma I.M., Stevenson J.K., Schwarz E.M. et al. Genes Dev 1995. Vol. 9. P. 2723–2735.
38. Okada M., Okamoto T., Yamada S. et al. Successful tre- atment of chronic graft-versus-host disease with sulfasa- lazine in allogeneic bone marrow transplantation // Acta Haematol. 1999. Vol. 102. P. 107–109.
39. Ingrid H.C. Vos, Roland G., Hermann J. et al. NF-κB decoy oligodeoxynucleotides reduce monocyte infil- tration in renal allografts // FASEB J. 2000. Vol. 14. P. 815–822.
40. Morishita R., Sugimoto T., Aoki M. et al. In vivo trans- fection of cis element ‘decoy’ against nuclear factor-κB binding sites prevent myocardial infarction // Nat Med. 1997. Vol. 3. P. 894–899.
41. Jian-Feng Wei and Shu-Sen Zheng. NF-κB in allograft rejection // Hepatobilliary and Pancreatic Disease Inter- national. 2003. Vol. 2 (2). P. 180–183.
Review
For citations:
Kuncevich N.V. ROLE OF NUCLEAR FACTOR NF-κB IN ALLOGRAFT REJEKTION. Russian Journal of Transplantology and Artificial Organs. 2010;12(1):72-77. (In Russ.) https://doi.org/10.15825/1995-1191-2010-1-72-77
Views:
852
Email this article 