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Вестник трансплантологии и искусственных органов

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РОЛЬ НУКЛЕАРНОГО ФАКТОРА ТРАНСКРИПЦИИ NF-κB В РАЗВИТИИ ОТТОРЖЕНИЯ ТРАНСПЛАНТАТА

https://doi.org/10.15825/1995-1191-2010-1-72-77

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Аннотация

В обзоре представлена информация о роли нуклеарного фактора транскрипции NF-κB при отторжении пересаженного органа. Описаны структура и основные функции NF-κB. Представлены механизмы активации NF-κB при развитии отторжения пересаженного органа и его роль в следующих патологических процессах: активация эндотелиальных клеток, активация T-клеток реципиента, созревание дендритных клеток (антиген представляющих иммунных клеток). Рассмотрены возможные терапевтические подходы, направленные на изменение активности на NF-κB у трансплантологических больных и позволяющие продлить выживаемость пересаженного органа. 

Об авторе

Н. В. Кунцевич
ФГУ «Федеральный научный центр трансплантологии и искусственных органов им. академика В.И. Шумакова» Минздравсоцразвития РФ, Москва
Россия


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Для цитирования:


Кунцевич Н.В. РОЛЬ НУКЛЕАРНОГО ФАКТОРА ТРАНСКРИПЦИИ NF-κB В РАЗВИТИИ ОТТОРЖЕНИЯ ТРАНСПЛАНТАТА. Вестник трансплантологии и искусственных органов. 2010;12(1):72-77. https://doi.org/10.15825/1995-1191-2010-1-72-77

For citation:


Kuncevich N.V. ROLE OF NUCLEAR FACTOR NF-κB IN ALLOGRAFT REJEKTION. Russian Journal of Transplantology and Artificial Organs. 2010;12(1):72-77. (In Russ.) https://doi.org/10.15825/1995-1191-2010-1-72-77

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ISSN 1995-1191 (Print)
ISSN 2412-6160 (Online)