РОЛЬ НУКЛЕАРНОГО ФАКТОРА ТРАНСКРИПЦИИ NF-κB В РАЗВИТИИ ОТТОРЖЕНИЯ ТРАНСПЛАНТАТА
https://doi.org/10.15825/1995-1191-2010-1-72-77
Аннотация
В обзоре представлена информация о роли нуклеарного фактора транскрипции NF-κB при отторжении пересаженного органа. Описаны структура и основные функции NF-κB. Представлены механизмы активации NF-κB при развитии отторжения пересаженного органа и его роль в следующих патологических процессах: активация эндотелиальных клеток, активация T-клеток реципиента, созревание дендритных клеток (антиген представляющих иммунных клеток). Рассмотрены возможные терапевтические подходы, направленные на изменение активности на NF-κB у трансплантологических больных и позволяющие продлить выживаемость пересаженного органа.
Об авторе
Н. В. Кунцевич
ФГУ «Федеральный научный центр трансплантологии и искусственных органов им. академика В.И. Шумакова» Минздравсоцразвития РФ, Москва
Россия
Россия
Список литературы
1. Sen R., Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequence // Cell. 1986. Vol. 80. P. 321–330.
2. Li Q., Verma I.M. NF-κB regulation in the immune sys- tem // Nat. Rev. Immunol. 2002. Vol. 2. P. 925–934.
3. Karin M., Lin A. NF-κB at the cross roads of life and
4. death // Nat. Immunol. 2002. Vol. 3. P. 221–227.
5. Baeuerle P.A., Baltimere D. NF-κB: Ten years after. Cell.
6. Vol. 87. P. 13–20.
7. Lopez F.O., Suzuki Y., Sanjuan G. et al. Nuclear factor-
8. κB inhibitors as potential novel anti-inflammatory agents for the treatment of immune glomerulonephritis // Am J. Pathol. 2002. Vol. 161. P. 1497–1505.
9. Ghosh S., May M., Kopp E. NF-κB and Rel proteins: evolutionarily conserved mediators of the immune re- sponse // Ann Rev. Immunol. 1998. Vol. 16. P. 225–260.
10. Thanos D., Maniatis T. NF-κB: a lesson in family va- lues // Cell. 1995. Vol. 80. P. 529–532.
11. Ben-Neriah Y. Regulatory functions of ubiquitination in the immune system // Nat. Immunol. 2002. Vol. 3. P. 20–26.
12. Barnes P.J., Karin M. Nuclear factor-κB: a pivotal tran- scription factor in chronic inflammatory diseases // N. Eng. J. Med. 1997. Vol. 336. P. 1066–1071.
13. May M.J., Sankar G. Signal transduction through NF- κB // Immunol. Today. 1998. Vol. 19. P. 80–88.
14. Solez K., Racusen L.C., Abdulkareem F. et al. Adhesion molecules and rejection of renal allograft // Kidney Int. 1997. Vol. 51. P. 1476–1480.
15. Feeley B.T., Miniati D.N., Park A.K. et al. Nuclear fac- tor-kappa B transcription factor decoy treatment inhibits graft coronary artery disease after cardiac transplanta- tion in rodents // Transplantation. 2000. Vol. 70. P. 1560– 1568.
16. Vos I.H., Govers R., Grone H.J. et al. NF-κB decoy oli- godexynucleotides reduce monocyte infiltration in renal allografts // FASEB J. 2000. Vol. 14. P. 815–822.
17. Brand K., Page S., Walli A.K. et al. Role of nuclear fac- tor-κB in atherogenesis // Exp. Physiol. 1997. Vol. 82. P. 297–304.
18. Janssen-Heininger Y.M., Poynter M.E., Baeuerle P.A. Recent advances towards understanding redox mecha- nisms in the activation of nuclear factor-κB // Free Ra- dic. Biol. Med. 2000. Vol. 28. P. 1317–1327.
19. Haddad J.J. Redox regulation of pro-inflammatory cy- tokines and IκB-alpha/NF-κB nuclear translocation and activation // Biochem. Biophy Res. Commun. 2002. Vol. 296. P. 847–856.
20. Russell M.E., Wallace A.F., Hancock W. et al. Up-regula- tion of cytokines associated with macrophage activation in the Lewis-to-F344 rat transplantation model of chro- nic cardiac rejection // Transplantation 1995. Vol. 59. P. 572–578.
21. Sakurai H., Hisada Y., Ueno M. et al. Activation of tran- scription factor NF-κB in experimental glomerulonephri- tis in rats // Biochim. Biophys. Acta. 1996. Vol. 1316. P. 132–138.
22. Azuma H., Tomita N., Kaneda Y. et al. Transfection of NF-κB-decoy oligodeoxynucleotides using efficient ul- trasound mediated gene transfer into donor kidneys pro- longed survival of rat renal allografts // Gene Ther. 2003. Vol. 10. P. 415–425.
23. Alcalde G., Merino J., Sanz S. et al. Circulating adhesion molecules during kidney allograft rejection // Transplan- tation. 1995. Vol. 59. P. 1695–1699.
24. Albert S., Baldwin Jr. Series introduction: the transcrip- tion factor NF-κB and human disease // J. Clin. Invest. 2001. Vol. 107. P. 1024.
25. Meldrum D.R. Tumor necrosis factor in the heart // Am J. Physiol. 1998. Vol. 274. P. R577–R595.
26. Finn P.W., Stone J.R., Boothby M.R. et al. Inhibition of NF-κB-dependent T-cell activation abrogates acute allo- graft rejection // J. Immunol. 2001. Vol. 167. P. 245–252.
27. Thomson A.W., Lu L. Dendritic cells as regulators of immune reactivity: implications for transplantation // Transplantation. 1999. Vol. 68. P. 1–8.
28. Lu L., Mc Caslin D., Starzl T.E. et al. Bone marrow-de- rived dendritic cell progenitors induce alloantigen-spe- cific hyporesponsiveness in murine T-lymphocytes // Transplantation. 1995. Vol. 60. P. 1539–1545.
29. Lu L., Bonham C.A., Chambers F.G. et al. Induction of nitric oxide synthase in mouse dendritic cells by IFN-gamma, endotoxin, and interaction with alloge- neic T-cells: Nitric oxide production is associated with dendritic cell apoptosis // J. Immunol. 1996. Vol. 157. P. 3577 –3586.
30. Rescigno M., Martino M., Sutherland C.L. et al. Den- dritic cell survival and maturation are regulated by dif- ferent signaling pathways // J. Exp. Med. 1998. Vol. 188. P. 2175–2180.
31. Lu L., Thomson A.W. Manipulation of dendritic cells for tolerance induction in transplantation and autoimmune disease // Transplantation. 2002. Vol. 73. P. S19–22.
32. Potoka D.A., Nadler E.P., Zhou X. et al. Inhibition of NF-κB by IκB prevents cytokine-induced NO produc- tion and promotes enterocyte apoptosis in vitro // Shock. 2000. Vol. 14. P. 366–373.
33. Lee J.I., Ganster R.W., Geller D.A. et al. Cyclosporine A inhibits the expression of costimulatory molecules on in vitro generated dendritic cells: association with redu- ced nuclear translocation of nuclear factor-κB // Trans- plantation. 1999. Vol. 68. P. 1255–1263.
34. Giannoukakis N., Bonham A., Qian S.G. et al. Prolon- gation of cardiac allograft survival using dendritic cells treated with NF-κB decoy oligodeoxyribonucleotides // Molecular Therapy. 2000. Vol. 1. P. 430–437.
35. Yamamoto Y., Gaynor R.B. Therapeutic potential of in- hibition of the NF-κB pathway in the treatment of in- flammation and cancer // J. Clin. Invest. 2001. Vol. 107. P. 135–142.
36. Sheri M.F., Jeffrey S.C., Laura S.G. et al. A D-amino acid peptide inhibitor of NF-κB nuclear localization if effica- cious in, odels of inflammatory disease // J. Immunol. 2000. Vol. 165. P. 10 004–10 012.
37. Verma I.M., Stevenson J.K., Schwarz E.M. et al. Genes Dev 1995. Vol. 9. P. 2723–2735.
38. Okada M., Okamoto T., Yamada S. et al. Successful tre- atment of chronic graft-versus-host disease with sulfasa- lazine in allogeneic bone marrow transplantation // Acta Haematol. 1999. Vol. 102. P. 107–109.
39. Ingrid H.C. Vos, Roland G., Hermann J. et al. NF-κB decoy oligodeoxynucleotides reduce monocyte infil- tration in renal allografts // FASEB J. 2000. Vol. 14. P. 815–822.
40. Morishita R., Sugimoto T., Aoki M. et al. In vivo trans- fection of cis element ‘decoy’ against nuclear factor-κB binding sites prevent myocardial infarction // Nat Med. 1997. Vol. 3. P. 894–899.
41. Jian-Feng Wei and Shu-Sen Zheng. NF-κB in allograft rejection // Hepatobilliary and Pancreatic Disease Inter- national. 2003. Vol. 2 (2). P. 180–183.
Рецензия
Для цитирования:
Кунцевич Н.В. РОЛЬ НУКЛЕАРНОГО ФАКТОРА ТРАНСКРИПЦИИ NF-κB В РАЗВИТИИ ОТТОРЖЕНИЯ ТРАНСПЛАНТАТА. Вестник трансплантологии и искусственных органов. 2010;12(1):72-77. https://doi.org/10.15825/1995-1191-2010-1-72-77
For citation:
Kuncevich N.V. ROLE OF NUCLEAR FACTOR NF-κB IN ALLOGRAFT REJEKTION. Russian Journal of Transplantology and Artificial Organs. 2010;12(1):72-77. (In Russ.) https://doi.org/10.15825/1995-1191-2010-1-72-77
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