BONE MINERAL DENSITY AFTER LIVER TRANSPLANTATION
https://doi.org/10.15825/1995-1191-2010-1-38-44
Abstract
Bone mineral density (BMD) was estimated twice in 18 recipents of ortotopic liver transplantation. There was decreased BMD in axial so as in peripheral skeleton in early time and in vertebral or hip Ward triangle in late time following transplantation being lower in primary biliary cirrosis then in cirrosis following chronic virus hepatitis despite tacrolimus immunosupression without prednisolon. Tacrolimus immunosupression with prednisolon in primary biliary cirrosis patients in late postoperative time was associated with hard BMD lowering which correlated with glucocorticoid therapy duration and prednisolon cumulative dosis.
About the Authors
V. P. Buzulina
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
Y. G. Moysyuk
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
I. A. Pronchenko
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
T. K. Koliashvili
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
E. B. Yaroshenko
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
M. N. Kornilov
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
N. P. Shmerko
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
I. P. Yermakova
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
References
1. Bagur A., Mautalen C., Findor J. et al. Risk factors for the development of vertebral and total skeleton osteopo- rosis in patients with primary biliary cirrhosis // Calcif Tissue Int. 1998. Vol. 63 (5). P. 385–390.
2. Carey E.J., Balan V., Kremers W.K., Hay J.E. Osteopenia and osteoporosis in patients with end-stage liver disease caused by hepatitis C and alcoholic liver disease: not just a cholestatic problem // Liver Transpl. 2003. Vol. 9 (11). P. 1166–1173.
3. Cohen A., Shane E. Osteoporosis after solid organ and bone marrow transplantation // Osteoporos Int. 2003. Vol. 14 (8). P. 617–630.
4. Collier J. Bone disorders in chronic liver disease // Hepa- tology. 2007. Vol. 46 (4). P. 1271–1278.
5. Compston J.E. Osteoporosis after liver transplantation // Liver Transpl. 2003. Vol. 9 (4). P. 321–330.
6. Gasser R.W. Cholestasis and metabolic bone disease – a clinical review // Wien. Med. Wochenschr. 2008. Vol. 158 (19–20). P. 553–557.
7. Giannini S., Nobile M., Ciuffreda M. et al. Long-term per- sistence of low bone density in orthotopic liver transplan- tation // Osteoporos Int. 2000. Vol. 11 (5). P. 417–424.
8. Guichelaar M.M., Malinchoc M., Sibonga J. et al. Bone metabolism in advanced cholestatic liver disease: anal- ysis by bone histomorphometry // Hepatology. 2002. Vol. 36 (4 Pt 1). P. 895–903.
9. Guichelaar M.M., Malinchoc M., Sibonga J. et al. Im- munosuppressive and postoperative effects of ortho- topic liver transplantation on bone metabolism // Liver Transpl. 2004. Vol. 10 (5). P. 638–647.
10. Guichelaar M.M., Kendall R., Malinchoc M., Hay J.E. Bone mineral density before and after OLT: long-term follow-up and predictive factors // Liver Transpl. 2006. Vol. 12 (9). P. 1390–1402.
11. Guichelaar M.M., Schmoll J., Malinchoc M., Hay J.E. Fractures and avascular necrosis before and after ortho- topic liver transplantation: long-term follow-up and pre- dictive factors // Hepatology. 2007. Vol. 46 (4). P. 1198– 1207.
12. Hamburg S.M., Piers D.A., van den Berg A.P. et al. Bone mineral density in the long term after liver transplanta- tion // Osteoporos Int. 2000. Vol. 11 (7). P. 600–606.
13. Mart G., Gomez R., Jodar E. et al. Long-term follow-up of bone mass after orthotopic liver transplantation: effect of steroid withdrawal from the immunosuppressive regi- men // Osteoporos Int. 2002. Vol. 13 (2). P. 147–150.
14. Mounach A., Ouzzif Z., Wariaghli G. et al. Primary bili- ary cirrhosis and osteoporosis: a case-control study // J Bone Miner Metab. 2008. Vol. 26 (4). P. 379–384.
15. Ninkovic M., Love S.A., Tom B. et al. High prevalence of osteoporosis in patients with chronic liver disease prior to liver transplantation // Calcif Tissue Int. 2001. Vol. 69 (6). P. 321–326.
Review
For citations:
Buzulina V.P., Moysyuk Y.G., Pronchenko I.A., Koliashvili T.K., Yaroshenko E.B., Kornilov M.N., Shmerko N.P., Yermakova I.P. BONE MINERAL DENSITY AFTER LIVER TRANSPLANTATION. Russian Journal of Transplantology and Artificial Organs. 2010;12(1):38-44. (In Russ.) https://doi.org/10.15825/1995-1191-2010-1-38-44
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