MORPHOLOGICAL PREDICTORS OF KIDNEY ALLOGRAFT (KAG) FUNCTION DURING FIRST POSTTRANSPLANT YEAR
https://doi.org/10.15825/1995-1191-2010-1-21-26
Abstract
The retrospective analysis of the influence of histological changes in donor kidneys on the KAG function during first year was conducted in 75 recipients of a cadaveric kidney. The state of tubuli, glomeruli, interstitium, vessels was assessed semiquantitatively in the material of «0»-biopsies. The endpoints were serum creatinine and glomerular filtration rate at 3, 6 and 12 months. KAG function in the first year is programmed by histological changes in all compartments of donor kidney. Influence of histological changes is time-dependent: the effect of ischemic damage shows up quickly, but disappeared after 6 months; the effect of arteriolohyalinosis and arteriosclerosis begins to show up later – since 6 months; changes in glomeruli have influence on a KAG function in 3 months and 1 year; interstitial fibrosis in cortex and medulla negatively influences KAG function on the extent of all first year. Our data argue for the necessity of «0»-biopsies examination for the prediction of KAG subsequent function.
About the Authors
A. V. Trailin
Zaporizhzhya interregional transplantation centre
Russian Federation
Russian Federation
T. N. Nikonenko
Zaporizhzhya interregional transplantation centre
Russian Federation
Russian Federation
A. S. Nikonenko
Zaporizhzhya interregional transplantation centre
Zaporizhzhya medical academy of postgraduate education
Russian Federation
Russian Federation
T. I. Ostapenko
Zaporizhzhya medical academy of postgraduate education
Russian Federation
Russian Federation
N. N. Polyakov
Zaporizhzhya interregional transplantation centre
Zaporizhzhya medical academy of postgraduate education
Russian Federation
Russian Federation
P. V. Pavlov
Dnypropetrovsk Mechnikov regional clinical hospital
Russian Federation
Russian Federation
O. D. Pokrova
Dnypropetrovsk Mechnikov regional clinical hospital
Russian Federation
Russian Federation
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Review
For citations:
Trailin A.V., Nikonenko T.N., Nikonenko A.S., Ostapenko T.I., Polyakov N.N., Pavlov P.V., Pokrova O.D. MORPHOLOGICAL PREDICTORS OF KIDNEY ALLOGRAFT (KAG) FUNCTION DURING FIRST POSTTRANSPLANT YEAR. Russian Journal of Transplantology and Artificial Organs. 2010;12(1):21-26. (In Russ.) https://doi.org/10.15825/1995-1191-2010-1-21-26
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