ТРАНСПЛАНТАЦИЯ ПЕЧЕНИ И HBV-ИНФЕКЦИЯ
https://doi.org/10.15825/1995-1191-2009-4-110-117
Аннотация
В статье представлены современные данные по трансплантации печени при HBV-инфекции. Показано, что пациенты с циррозом печени HBV-этиологии, ожидающие трансплантации печени, должны длитель- но получать аналоги нуклеоз(т)идов вплоть до ОТП. Обсуждаются различные схемы профилактики воз- вратной HBV-инфекции в посттрансплантационном периоде и специфическое лечение de novo гепатита В после ОТП, возможность выполнения ОТП пациентам с ГЦР в исходе цирроза печени HBV-этиологии.
Об авторах
О. И. АндрейцеваРоссия
А. В. Козлова
Россия
В. Е. Сюткин
Россия
Список литературы
1. Шерлок Ш., Дули Д. Рецидив болезни // Заболевания пе- чени и желчных путей. М.: ГЭОТАР Медицина, 1999. С. 756.
2. Angelico M., Di Paolo D., Trinito M.O. et al. Failure of a reinforced triple course of hepatitis B vaccination in pa- tients transplanted for HBV-related cirrhosis // Hepatology. 2002. Vol. 35. P. 176–181.
3. Angus P.W., McCaughan G.W., Gane E.J. et al. Combina- tion low-dose hepatitis B immune globulin and lamivudine therapy provides effective prophylaxis against posttrans- plantation hepatitis B // Liver Transpl. 2000. Vol. 6. P. 429– 433.
4. Angus P.W., Patterson S.J., Strasser S.I. et al. A randomized study of adefovir dipivoxil in place of HBIG in combina- tion with lamivudine as post-liver transplantation hepatitis B prophylaxis // Hepatology. 2008. Vol. 48. P. 1460–1466.
5. Barcena R., Moraleda G., Moreno J. et al. Prevention of de novo HBV infection by the presence of anti-HBs in trans- planted patients receiving core antibody-positive livers // World J. Gastroenterol. 2006. Vol. 7; 12 (13). P. 2070– 2074.
6. Buti M., Mas A., Prieto M. et al. A randomized study com- paring lamivudine monotherapy after a short course of hepatitis B immune globulin (HBIg) and lamivudine with long-term lamivudine plus HBIg in the prevention of hepa- titis B virus recurrence after liver transplantation // J. Hepa- tol. 2003. Vol. 38. P. 811–817.
7. Cahlin C., Olausson M., Friman S. Severe clinical course of de novo hepatitis B infection after liver transplantation // Transplant. Proc. 2001. Vol. 33 (4). P. 2467–2468.
8. Castells L., Esteban R. Hepatitis B vaccination in liver transplant candidates // Eur. J. Gastroenterol. Hepatol. 2001. Vol. 13 (4). P. 359–361.
9. Castells L., Vargas V., Rodríguez F. et al. Clinical impact and efficacy of lamivudine therapy in de novo hepatitis B infection after liver transplantation // Liver Transpl. 2002. Vol. 8 (10). P. 892–900.
10. Chazouilleres O., Mamish D., Kim M. et al. «Occult» hepa- titis B virus as source of infection in liver transplant reci- pients // Lancet. 1994. Vol. 343 (8890). P. 142–146.
11. Crespo J., Fábrega E., Casafont F. et al. Severe clinical course of de novo hepatitis B infection after liver trans- plantation // Liver Transpl. Surg. 1999. No 5 (3). P .175– 183.
12. Degertekin B., Lok A.F. Hepatocellular Carcinoma (HCC) is the main Indication for Liver Transplantation (OLT) among HBV Patients in the era of Nucleos/tide Analogue Therapies, 59th AASLD Meeting, October 31-November 4, 2008, San Francisco, USA // Hepatology. 2008; 48 (abstract 1437).
13. Dickson R.C., Everhart J.E., Lake J.R. et al. Transmission of hepatitis B by transplantation of livers from donors posi- tive for antibody to hepatitis B core antigen. The National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database // Gastroenterology. 1997. Vol. 113 (5). P. 1668–1674.
14. Dodson S.F., de Vera M.E., Bonham C.A. et al. Lamivudine after hepatitis B immune globulin is effective in preventing hepatitis B recurrence after liver transplantation // Liver Transpl. 2000. Vol. 6. P. 434–439.
15. Douglas D.D., Rakela J., Taswell H. et al. Transmission of hepatitis B virus infection from orthtopic donor livers [ab- stract] // Hepatology. 1992. Vol. 16. P. 49A.
16. Douglas D.D., Rakela J., Wright T.L. et al. The clinical course of transplantation-associated de novo hepatitis B infection in the liver transplant recipient // Liver Transpl. Surg. 1997. Vol. 3 (2). P. 105–111.
17. Fabia R., Levy M., Crippin J. et al. De novo hepatitis B infection after liver transplantation: sources of disease, in- cidence and impact // Liver. Transpl. Surg. 1997. Vol. 4. P. 119–127.
18. Gane E.J., Angus P.W., Strasser S. et al. Lamivudine plus low-dose hepatitis B immunoglobulin to prevent recurrent hepatitis B following liver transplantation // Gastroentero- logy. 2007. Vol. 132. P. 931–937.
19. Grellier L., Mutimer D., Ahmed M. et al. Lamivudine prop- hylaxis against reinfection in liver transplantation for hepa- titis В cirrhosis // Lancet. l996. Vol. 348. P. 1212–1215.
20. Hussain M., Soldevila-Pico C., Emre S. et al. Presence of intrahepatic (total and ccc) HBV DNA is not predictive of HBV recurrence after liver transplantation // Liver Transpl. 2007. Vol. 13. P. 1137–1144.
21. Hwang S., Lee S.G., Ahn C.S. et al. Prevention of hepati- tis B recurrence after living donor liver transplantation: pri- mary high-dose hepatitis B immunoglobulin monotherapy and rescue antiviral therapy // Liver Transpl. 2008. Vol. 14. P. 770–778.
22. Jiao Z.Y., Jiao Z. Prophylaxis of recurrent hepatitis B in Chinese patients after liver transplantation using lamivudi- ne combined with hepatitis B immune globulin according to the titer of antibody to hepatitis B surface antigen // Trans- plant. Proc. 2007. Vol. 39. P. 1533–1536.
23. Jiao Z.Y., Yan L.N., Li B. et al. Liver transplantation for chronic hepatitis B patients with lamivudine monotherapy or lamivudine combined with individualized low-dose he- patitis B immunoglobulin treatment // Zhonghua Ganzang- bing Zazhi. 2007. Vol. 15. P. 804–808.
24. Karademir S., Astarcioglu H., Akarsu M. et al. Prophylactic use of low-dose, on-demand, intramuscular hepatitis B im- munoglobulin and lamivudine after liver transplantation // Transplant. Proc. 2006. Vol. 38. P. 579–583.
25. Kim K.K., Kim K.H., Hwang S. et al. Therapeutic effect of adefovir dipivoxil on recurrent or de novo infection of hepatitis B virus after liver transplantation: a preliminary report. Article in Korean // Korean. J. Gastroenterol. 2005. Vol. 45 (3). P. 174–180.
26. Lampertico P., Viganò M., Donato M. et al. Excellent 5-year overall survival in patients with HBV-related cirrhosis un- dergoing transplantation for hepatocellular carcinoma, 59th AASLD Meeting, October 31-November 4, 2008, San Fran- cisco, USA // Hepatology. 2008. Vol. 48 (abstract 621).
27. Lauchart W., Muller R., Pichlmayr R. Long-term immunopro- phylaxis of hepatitis B virus reinfection in recipients of human liver allografts // Transplant. Proc. 1987. Vol. 19. P. 4051–4053.
28. Li Jiang, Li-Sheng Jiang, Nan-Sheng Cheng and Lu-Nan Yan. Current prophylactic strategies against hepatitis B vi- rus recurrence after liver transplantation // World. J. Gas- troenterol. 2009 May 28. No 15 (20). Р. 2489–2499.
29. Limquiaco J.L., Wong J., Wong V.W. et al. Lamivudine mo- noprophylaxis and adefovir salvage for liver transplantation in chronic hepatitis B: a seven-year follow-up study // J. Med. Virol. 2009. Vol. 81. Р. 224–229.
30. Lo C.M., Cheung S.T., Lai C.L. et al. Liver transplantation in Asian patients with chronic hepatitis В using lamivudine prophylaxis // Ann. Surg. 2001. Vol. 233. Р. 276–281.
31. Lok A.S., Heathcote E.J., Hoofnagle J.H. Management of hepatitis B: 2000 – summary of a workshop // Gastroenterology. 2001. Vol. 120. Р. 1828–1853.
32. Markowitz J.S., Martin P., Conrad A.J. et al. Prophylaxis against hepatitis B recurrence following liver transplanta- tion using combination lamivudine and hepatitis B immune globulin // Hepatology. 1998. Vol. 28. Р. 585–589.
33. McGory R.W., Ishitani M.B., Oliveira W.M. et al. Improved outcome of orthotopic liver transplantation for chronic he- patitis B cirrhosis with aggressive passive immunization // Transplantation. 1996. Vol. 61. Р. 1358–1364.
34. Mutimer D., Dusheiko G., Barrett C. et al. Lamivudine wit- hout HBIg for prevention of graft reinfection by hepatitis B: long-term follow-up // Transplantation. 2000. Vol. 70. Р. 809–815.
35. Mutimer D., Pillay D., Dragon E. et al. High pre-treatment serum hepatitis В virus titre predicts failure of lamivudine prophylaxis and graft re-infection after liver transplantation // J. Hepatol. 1999. Vol. 30. Р. 715–721.
36. Nevin Yilmaz, Mitchell L. Shiffman, R. Todd Stravitz et al. Prophylaxis Against Recurrance of Hepatitis B Virus After Liver Transplantation: A Retrospective Analysis Spanning 20 Years // J. Liver International. January 2008. Vol. 28 (1). Р. 72–78.
37. Patterson S.J., Angus P.W. Post-liver transplant hepatitis B prophylaxis: the role of oral nucleos(t)ide analogues // Current opinion in organ transplantation. 2009. Vol. 14. Р. 225–230.
38. Pellicelli A.M., Barbaro G., Barbarini G. et al. Efficacy of Entecavir as rescue therapy in lamivudine-resistant patients with HBV liver cirrhosis and waiting for orthotopic liver transplantation, 59th AASLD Meeting, October 31 – No- vember 4, 2008, San Francisco, USA // Hepatology. 2008. Vol. 48: 4 (suppl.). Р. 701A (abstract 885).
39. Perrillo R.P., Wright T., Rakela J. et al. A multicenter United States-Canadian trial to assess lamivudine monotherapy be- fore and after liver transplantation for chronic hepatitis B // Hepatology. 2001. Vol. 33. Р. 424–432.
40. Prieto M., Gomez M., Berenguer M. et al. De novo he- patitis B after liver transplantation from hepatitis B core antibody–positive donors in an area with high prevalence of anti-HBc positivity in the donor population // Liver Transpl. 2001. No 7. Р. 51–58.
41. Roche B., Samuel D., Gigou M. et al. De novo and apparent de novo hepatitis B virus infection after liver transplanta- tion // J. Hepatol. 1997. Vol. 26 (3). Р. 517–526.
42. Roque-Afonso A.M., Feray C., Samuel D. et al. Antibodies to hepatitis B surface antigen prevent viral reactivation in recipients of liver grafts from anti-HBC positive donors // Gut. 2002. Vol. 50 (1). Р. 95–99.
43. Samuel D., Bismuth A., Mathieu D. et al. Passive immuno- prophylaxis after liver transplantation in HBs-Ag-positive patients // Lancet. 1991. Vol. 337. Р. 813–815.
44. Samuel D., Muller M., Alexander G. et al. Liver transplan- tation in European patients with the hepatitis B surface an- tigen // N. Engl. J. Med. 1993. Vol. 329. Р. 1842–1847.
45. Sanchez-Fueyo A., Rimola A., Grande L. et al. Hepatitis B immunoglobulin discontinuation followed by hepatitis B virus vaccination: A new strategy in the prophylaxis of hepatitis B virus recurrence after liver transplantation // He- patology. 2000. Vol. 31. Р. 496–501.
46. Seehofer D., Rayes N., Berg T. et al. Lamivudine as first- and second-line treatment of hepatitis B infection after liver transplantation // Transpl. Int. 2000. Vol. 13. Р. 290–296.
47. Segovia R., Sanchez-Fueyo A., Rimola A. et al. Evidence of serious graft damage induced by de novo hepatitis B virus infection after liver transplantation // Liver Transpl. 2001. No 7. Р. 106–112.
48. Su W.J., Ho M.C., Ni Y.H. et al. High-titer antibody to he- patitis B surface antigen before liver transplantation can prevent de novo hepatitis B infection // J. Pediatr. Gastroen- terol. Nutr. 2009. Vol. 48 (2). Р. 203–208.
49. Toniutto P., Fumo E., Caldato M. et al. Favourable outcome of adefovir-dipivoxil treatment in acute de novo hepatitis B after liver transplantation // Transplantation. 2004. Vol. 15; 77 (3). Р. 472–473.
50. Uemoto S., Sugiyama K., Marusawa H. et al. Transmission of hepatitis B virus from hepatitis B core antibody-positive donors in living related liver transplants // Transplantation. 1998. Vol. 65 (4). Р. 494–499.
51. Umeda M., Marusawa H., Ueda M. et al. Beneficial effects of short-term lamivudine treatment for de novo hepatitis B virus reactivation after liver transplantation // Am. J. Trans- plant. 2006. Vol. 6 (11). Р. 2680–2685.
52. Villeneuve J.P., Condreay L.D., Willems B. et al. Lamivudine treatment for decompensated cirrhosis resulting from chronic hepatitis B // Hepatology. 2000. Vol. 31. Р. 207–210.
53. Wachs M.E., Amend W.J., Ascher N.L. et al. The risk of transmission of hepatitis B from HBsAg(–), HBcAb(+), HBIgM(–) organ donors // Transplantation. 1995. Vol. 59 (2). Р. 230–234.
54. Yao F.Y., Bass N.M. Lamivudine treatment in patients with severely decompensated cirrhosis due to replicating hepati- tis В infection // J. Hepatоl. 2000. Vol. 33. Р. 301–307.
55. Yao F.Y., Terrault N.A., Freise C. et al. Lamivudine treat- ment is beneficial in patients with severely decompensa- ted cirrhosis and actively replicating hepatitis В infection awaiting liver transplantation: a comparative study using a matched, untreated cohor // Hepatology. 2001. Vol. 34. Р. 411–416.
56. Zheng S., Chen Y., Liang T. et al. Prevention of hepatitis B recurrence after liver transplantation using lamivudine or lamivudine combined with hepatitis B Immunoglobulin prophylaxis // Liver Transpl. 2006. Vol. 12. Р. 253–258.
Рецензия
Для цитирования:
Андрейцева О.И., Козлова А.В., Сюткин В.Е. ТРАНСПЛАНТАЦИЯ ПЕЧЕНИ И HBV-ИНФЕКЦИЯ. Вестник трансплантологии и искусственных органов. 2009;11(4):110-117. https://doi.org/10.15825/1995-1191-2009-4-110-117
For citation:
Andreytseva O.I., Kozlova A.V., Sutkin V.E. LIVER TRANSPLANTATION AND HBV INFECTION. Russian Journal of Transplantology and Artificial Organs. 2009;11(4):110-117. (In Russ.) https://doi.org/10.15825/1995-1191-2009-4-110-117