THE EXPERIENCE OF IMMUNOHISTOCHEMICAL INVESTIGATION OF ENDOMIOCARDIAL BIOPSIES FOR THE DIAGNOSIS OF THE HUMORAL REJECTION IN THE PATIENTS WITH HEART ALLOGRAFT
https://doi.org/10.15825/1995-1191-2009-3-30-36
Abstract
The aim of present study was to characterize immunohistological features of humoral (antibody-mediated rejection, AMR) by evaluating their manifestation, localization and distribution in endomiocardial biopsies (EMBs) from patients after heart transplantation. The role of AMR in the development of allograft vasculopathy is investigated widely. The examine of more than 1000 EMBs maid it possible to elaborate the diagnostic criteria of acute humoral rejection, to characterize immunomorfological peculiarities of long-term heart allograft and demonstrated the relation AMR with the early development of coronary artery diseases.
About the Authors
A. G. Kupriyanova
Academician V.I. Shumakov Federal Research Center of transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
L. V. Beletskaya
Academician V.I. Shumakov Federal Research Center of transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
V. A. Zaydenov
Academician V.I. Shumakov Federal Research Center of transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
A. Y. Kormer
Academician V.I. Shumakov Federal Research Center of transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
E. N. Kazakov
Academician V.I. Shumakov Federal Research Center of transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
A. M. Golts
Academician V.I. Shumakov Federal Research Center of transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
V. V. Chestukhin
Academician V.I. Shumakov Federal Research Center of transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
I. M. Iljinsky
Academician V.I. Shumakov Federal Research Center of transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
E. I. Ryaboschtanova
Academician V.I. Shumakov Federal Research Center of transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Kupriyanova A.G., Beletskaya L.V., Zaydenov V.A., Kormer A.Y., Kazakov E.N., Golts A.M., Chestukhin V.V., Iljinsky I.M., Ryaboschtanova E.I. THE EXPERIENCE OF IMMUNOHISTOCHEMICAL INVESTIGATION OF ENDOMIOCARDIAL BIOPSIES FOR THE DIAGNOSIS OF THE HUMORAL REJECTION IN THE PATIENTS WITH HEART ALLOGRAFT. Russian Journal of Transplantology and Artificial Organs. 2009;11(3):30-36. (In Russ.) https://doi.org/10.15825/1995-1191-2009-3-30-36
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