ENDOTOXIN ADSORPTION IN SEPSIS IN PATIENTS AFTER RENAL TRANSPLANTATION AND GRAFT FUNCTION
https://doi.org/10.15825/1995-1191-2012-4-33-39
Abstract
Objective: to evaluate the influence of endotoxin adsorption on graft function and mortality. Methods: we analy- zed the results of treatment of 90 patients with bacterial complications after renal transplantation and compared them with retrospective group of patients, who didn’t undergo endotoxin adsorption. Results: the use of endo- toxin adsorption led to significant improvement of graft function and intraorganic microcirculation in compa- rison with retrospective group, treated without endotoxin adsorption. Survival was higher in the intervention group. However, endotoxin adsorption did not affect patient survival when multiple organ failure developed. Conclusion: when infectious complications developed, endotoxin adsorption is able to improve the graft function and recipient survival significantly. The earliest application of this procedure is recommended.
About the Authors
A. V. Vatazin
Moscow Regional State Institute for Clinical Research M.F. Vladimirsky
Russian Federation
Russian Federation
A. B. Zulkarnaev
Moscow Regional State Institute for Clinical Research M.F. Vladimirsky
M. Krstich
Moscow Regional State Institute for Clinical Research M.F. Vladimirsky
References
1. Аниховская И.А., Опарина О.Н., Яковлева М.М., Яков- лев М.Ю. Кишечный эндотоксин как универсальный фактор адаптации и патогенеза общего адаптацион- ного синдрома // Физиология человека. 2006. Т. 32. No 2. С. 87–91.
2. Яковлев М.Ю. Элементы эндотоксиновой теории фи- зиологии и патологии человека // Физиология чело- века. 2003. No 4. С. 154–164.
3. Яковлев М.Ю. Кишечный липополисахарид: систем- ная эндотоксинемия – эндотоксиновая агрессия – SIR-синдром и полиорганная недостаточность как звенья одной цепи // Бюлл. ВНЦ РАМН. 2005. No 1. С. 15–18.
4. Яковлев М.Ю. Кишечный эндотоксин – SIRS – поли- органная недостаточность // Труды РОП. 2006. Т. 1. С. 437–440.
5. Antonelli M., Fumagalli R., Cruz D.N. et al. PMX en- dotoxin removal in the clinical practice: results from the EUPHAS trial. // Contrib Nephrol. 2010. No 167. P. 83–90.
6. Cardoso P.G., Macedo G.C., Azevedo V., Oliveira S.C. Brucella spp noncanonical LPS: structure, biosynthesis, and interaction with host immune system // Microb Cell Fact. 2006. Vol. 5. P. 13.
7. Cavaillon J.M. Polymyxin B for endotoxin removal in sepsis // Lancet Infect Dis. 2011. Vol. 11. No 6. P. 426–427.
8. Cruz D.N., Bellomo R., Ronco C. Clinical effects of po- lymyxin B-immobilized fiber column in septic patients //
9. Contrib Nephrol. 2007. No 156. P. 444–451.
10. Cruz D.N., Perazella M.A., Bellomo R. et al. Effective- ness of polymyxin B-immobilized fiber column in sep- sis: a systematic review // Crit Care. 2007. Vol. 11. No 2.
11. R47.
12. Linares L., Cofán F., Cervera C. et al. Infection-related
13. mortality in a large cohort of renal transplant recipients //
14. Transplant Proc. 2007. Vol. 39. No 7. P. 2225–2227.
15. Martin E.L., Cruz D.N., Monti G. et al. Endotoxin re- moval: how far from the evidence? The EUPHAS 2 Pro-
16. ject. // Contrib Nephrol. 2010. No 167. P. 119–125.
17. Sato K., Maekawa H., Sakurada M. et al. Direct he- moperfusion with polymyxin B immobilized fiber for abdominal sepsis in Europe // Surg Today. 2011. Vol. 41.
18. No 6. P. 754–760.
Review
For citations:
Vatazin A.V., Zulkarnaev A.B., Krstich M. ENDOTOXIN ADSORPTION IN SEPSIS IN PATIENTS AFTER RENAL TRANSPLANTATION AND GRAFT FUNCTION. Russian Journal of Transplantology and Artificial Organs. 2012;14(4):33-39. (In Russ.) https://doi.org/10.15825/1995-1191-2012-4-33-39
Views:
849
Email this article 