Modern materials for dermal skin substitute: principles of production and modern acellular products based on them
https://doi.org/10.15825/1995-1191-2026-2-173-187
Abstract
The treatment of extensive and deep wounds and burns remains a highly pressing issue in modern surgery. Many of the associated challenges are linked to dysfunction of the dermis – the connective tissue matrix of the skin. Without its full restoration, achieving satisfactory long-term wound healing outcomes is difficult. This review focuses on artificial acellular scaffolds for dermal regeneration, as well as the fundamental principles underlying their design. The scaffolds discussed (Integra, Giamatrix, SmartMatrix, and NovoSorb) are already widely used in clinical practice today and have demonstrated high effectiveness. Currently, most commercially available dermal substitute products, as well as tissue engineering solutions in general, are manufactured abroad. Therefore, evaluating international experience and applying it to the development of Russian-made scaffolds could significantly improve their accessibility for patients.
About the Authors
E. V. Sytina
Kurchatov Institute
Russian Federation
Russian Federation
Elena V. Sytina.
1, Plochad Akademika Kurchatova, Moscow, 123182
Phone: (495) 196-71-00 *63-47
A. A. Alekseev
Vishnevsky National Medical Research Center of Surgery
Russian Federation
Russian Federation
Moscow
A. A. Panteleyev
Kurchatov Institute; Vishnevsky National Medical Research Center of Surgery
Russian Federation
Russian Federation
Moscow
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Sytina E.V., Alekseev A.A., Panteleyev A.A. Modern materials for dermal skin substitute: principles of production and modern acellular products based on them. Russian Journal of Transplantology and Artificial Organs. 2026;28(2):173-187. (In Russ.) https://doi.org/10.15825/1995-1191-2026-2-173-187
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