vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2026-2-173-187vtio-2065Research ArticleРЕГЕНЕРАТИВНАЯ МЕДИЦИНА И КЛЕТОЧНЫЕ ТЕХНОЛОГИИREGENERATIVE MEDICINE AND CELL TECHNOLOGIESСовременные материалы для замещения дермы кожи: принципы получения и современные бесклеточные продукты на их основеModern materials for dermal skin substitute: principles of production and modern acellular products based on themhttps://orcid.org/0000-0002-5484-7157СытинаЕ. В.SytinaE. V.

Сытина Елена Вячеславовна - снс лаборатории биосовместимых материалов и тканевой инженерии НИЦ "Курчатовский институт".

123182, Москва, пл. Академика Курчатова, д. 1

Тел. (495) 196-71-00, доб. 63-47

Elena V. Sytina.

1, Plochad Akademika Kurchatova, Moscow, 123182

Phone: (495) 196-71-00 *63-47

esytina@mail.ruАлексеевА. А.AlekseevA. A.

Москва

Moscow

ПантелеевА. А.PanteleyevA. A.

Москва

Moscow

ФГБУ «Национальный исследовательский центр «Курчатовский институт»РоссияKurchatov InstituteRussian FederationФГБУ «Национальный медицинский исследовательский центр хирургии имени А.В. Вишневского» Минздрава РоссииРоссияVishnevsky National Medical Research Center of SurgeryRussian FederationФГБУ «Национальный исследовательский центр «Курчатовский институт»; ФГБУ «Национальный медицинский исследовательский центр хирургии имени А.В. Вишневского» Минздрава РоссииРоссияKurchatov Institute; Vishnevsky National Medical Research Center of SurgeryRussian Federation202628062026282173187Copyright © Сытина Е.В., Алексеев А.А., Пантелеев А.А., 20262026Сытина Е.В., Алексеев А.А., Пантелеев А.А.Sytina E.V., Alekseev A.A., Panteleyev A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/2065

Проблема заживления обширных и глубоких ран и ожогов является чрезвычайно актуальной в современной хирургии. Большинство сложностей в этой области связано с дисфункцией пораженной дермы – соединительно-тканной основы кожи. Без ее полноценного восстановления нельзя ожидать удовлетворительных результатов лечения ран в долгосрочной перспективе. Данный обзор посвящен рассмотрению искусственных бесклеточных скаффолдов для восстановления дермы, а также основным принципам дизайна таких материалов. Выбранные для рассмотрения скаффолды (Integra, Гиаматрикс, SmartMatrix, NovoSorb) уже сегодня активно применяются в клинической практике и отлично себя зарекомендовали. В настоящее время подавляющее большинство коммерческих продуктов для замещения дермы (как и вообще для тканевой инженерии) производится за рубежом. Оценка зарубежного опыта и его применение для разработки отечественных скаффолдов сделают такие продукты более доступными для пациентов.

The treatment of extensive and deep wounds and burns remains a highly pressing issue in modern surgery. Many of the associated challenges are linked to dysfunction of the dermis – the connective tissue matrix of the skin. Without its full restoration, achieving satisfactory long-term wound healing outcomes is difficult. This review focuses on artificial acellular scaffolds for dermal regeneration, as well as the fundamental principles underlying their design. The scaffolds discussed (Integra, Giamatrix, SmartMatrix, and NovoSorb) are already widely used in clinical practice today and have demonstrated high effectiveness. Currently, most commercially available dermal substitute products, as well as tissue engineering solutions in general, are manufactured abroad. Therefore, evaluating international experience and applying it to the development of Russian-made scaffolds could significantly improve their accessibility for patients.

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The authors declare that there are no conflicts of interest present.