HEMOFILTRATION AND COUPLED PLASMA FILTRATION ADSORPTION IMPACT ON TACROLIMUS BLOOD CONCENTRATION IN RENAL TRANSPLANT RECIPIENTS
https://doi.org/10.15825/1995-1191-2014-2-75-79
Abstract
Aim. To study the effect of hemofi ltration and coupled plasma fi ltration adsorption on tacrolimus blood concentration in renal transplant recipients.
Methods and results. The study included 8 renal transplant recipients. In these patients immediately after the operation was performed the coupled plasma fi ltration adsorption with hemofiltration using a cartridge Mediasorb to reduce the severity of reperfusion injury. We have found that during this extracorporeal blood correction procedure there was statistically not signifi cant decrease of tacrolimus blood concentration. However, concentration of tacrolimus remained in the therapeutic range even after the procedure and it was not signifi cantly different from the control point С0.
Conclusion. Coupled plasma fi ltration adsorption is safe in renal transplant recipients and has no signifi cant impact on tacrolimus blood concentration. However, the downward trend in the concentration of tacrolimus in the course of these procedures, especially in continuous or semicontinuous mode, as well as in patients with low hematocrit and hypoalbuminemia, requires individual monitoring.
About the Authors
A.V. Vatazin
Government Budget Health Institution of Moscow region «M.F. Vladimirsky Moscow Regional Research
Clinical Institute», Division of Transplantation, nephrology and surgical hemocorrection, Moscow, Russian
Federation
Russian Federation
Russian Federation
A.B. Zulkarnayev
Government Budget Health Institution of Moscow region «M.F. Vladimirsky Moscow Regional Research
Clinical Institute», Division of Transplantation, nephrology and surgical hemocorrection, Moscow, Russian
Federation
Russian Federation
Russian Federation
A.N. Kurchatova
Government Budget Health Institution of Moscow region «M.F. Vladimirsky Moscow Regional Research
Clinical Institute», Division of Transplantation, nephrology and surgical hemocorrection, Moscow, Russian
Federation
Russian Federation
Russian Federation
M. Krstich
Government Budget Health Institution of Moscow region «M.F. Vladimirsky Moscow Regional Research
Clinical Institute», Division of Transplantation, nephrology and surgical hemocorrection, Moscow, Russian
Federation
Russian Federation
Russian Federation
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Review
For citations:
Vatazin A., Zulkarnayev A., Kurchatova A., Krstich M. HEMOFILTRATION AND COUPLED PLASMA FILTRATION ADSORPTION IMPACT ON TACROLIMUS BLOOD CONCENTRATION IN RENAL TRANSPLANT RECIPIENTS. Russian Journal of Transplantology and Artificial Organs. 2014;16(2):75-79. (In Russ.) https://doi.org/10.15825/1995-1191-2014-2-75-79
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