NOSOCOMIAL INFECTION AND MICROBIAL BIOFILMS IN SURGERY
https://doi.org/10.15825/1995-1191-2012-3-83-91
Abstract
The review presents data on the role of biofilms formation by opportunistic microbes in surgery. It gives in- formation about the microbial structure of biofilms, their architecture and physiology. The attention was payed to significal importance of microbial communities, which form biofilms in surgery. Mechanisms of increased resistance of biofilms bacteria are compared with plankton. The review includes literature data on the process of formation biofilms on intravascular catheters and methods of inhibition and protection. Methods of studing formation and inhibition of biofilms in vitro and in vivo are presented. Different biotechnology methods, based on using antiadhesive, antiseptic, biophysical resources and biomaterials are discussed.
About the Authors
N. I. Gabrielyan
Academician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
E. M. Gorskaya
Academician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
N. I. Romanova
Academician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
O. M. Tsirulnikova
Academician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
References
1. Бондаренко В.М., Рыбальченко О.В., Орлова О.Г. и др. Дезорганизация биопленок клинических штам- мов стафилококков метаболитами лактобацилл // Журн. микробиол. 2010. No 6. C. 66–70.
2. Габриэлян Н.И., Толпекин В.Е., Шумаков Д.В. и др. 30-летний опыт применения контрпульсации и обхо- да желудочков сердца: проблема инфекции // Вест- ник трансплантологии и искусственных органов. 2006. No 4. C. 80–82.
3. Гинцбург А.Л., Романова Ю.М. Бактериальные био- пленки как естественная форма существования бак- терий в окружающей среде и организме хозяина // Журн. микробиол. 2011. No 3. С. 99–109.
4. Голуб А.В. Новые возможности профилактики ин- фекций области хирургического вмешательства // Клиническая микробиология и антимикробная хи- миотерапия. 2011. No 1. С. 56–66.
5. Ильина Т.С., Романова Ю.М., Гинцбург А.Л. Систе- ма коммуникаций у бактерий и их роль в патоген- ности // Мол. генет. микробиол. вирусол. 2006. No 3. C. 22–29.
6. Караев З.О., Мамедова Л.Р. Влияние лекарственных препаратов на образование биопленок Candida al- bicans // Проблемы медицинской микологии. 2010. No 3. С. 10–12.
7. Кузнецова М.В. Формирование биопленок нозоко- миальными штаммами Pseudomonas aeruginosa // Журн. микробиол. 2011. No 4. C. 8–14.
8. Романова Н.И., Буданова Е.В., Спирина Т.С. и др. Спо- собность к биопленкообразованию у госпитальных микроорганизмов // Матер. X научно-практической конфер. «Внутрибольничные инфекции в стацио- нарах различного профиля, профилактика, лечение осложнений». М., 2012. С. 58–59.
9. Романова Ю.М., Диденко Л.В., Толордава Э.Р. и др. Биопленки патогенных бактерий и их роль в хро- низации инфекционного процесса. Поиск средств борьбы с биопленками // Вестник РАМН. 2011. No 10. С. 31–39.
10. Тец Г.В. Роль внеклеточной ДНК и липидов матрикса во взаимодействии бактерий биопленок с антибиоти- ками: Дис. ... канд. мед. наук. СПб.–М., 2007.
11. Чеботарь И.В., Маянский А.Н., Кончакова Е.Д. и др. Антибиотикорезистентность биопленочных бак- терий // Клин. микробиол. антимикроб. химиотер. 2012. Т. 14. No 1. С. 51–58.
12. Adam B., Baillie G.S., Douglas L.J. Mixed species bio- films on Candida albicans and Staphylococcus epidermi- dis // J. Med. Microbiol. 2002. Vol. 51. P. 344–349.
13. Azeredo J., Sutherland I.W. The use of phages for the re- moval of infectious biofilms //Curr. Pharm. Biotechnol. 2008. Vol. 9 (4). P. 261–266.
14. Balaban N., Cirioni O., Giacometti A. et al. Treatment of Staphylococcus aureus biofilm infection by the quorum- sensing inhibitor RIP // Antimicrob. Agents Chemother. 2007. Vol. 51. P. 2226–2229.
15. Balestrino D., Souweine B., Charbonnel N. et al. Era- dication of microorganisms embedded in biofilm by an ethanol-based catheter lock solution // Nephrol. Dial. Transplant. 2009. Vol. 24. P. 3204–3209.
16. Banin E., Brady K.M., Greenberg E.P. Chelator-induced dispersal and killing of Pseudomonas aeruginosa cells in a biofilm // Appl. Environ. Microbiol. 2006. Vol. 72 (3). P. 2064–2069.
17. Betjes M.G.H., van Agteren M. Prevention of dialysis ca- theter-related sepsis with a citrate-taurolidine-containing lock solution // Nephrol. Dial. Transplant. 2004. Vol. 19. P. 1546–1551.
18. Garcia I., Conejo M.C., Ojeda A. et al. A dynamic in vitro model for evaluating antimicrobial activity against bacterial biofilms using a new device and clinical used catheters // J. Microb. Methods. 2010. Vol. 83. P. 307– 311.
19. Budhani R.K., Struthers J.K. Interaction of Streptococ- cus pneumoniae and Moraxella catarrhalis investigation of the indirect pathogenic role of a beta-lactamase-pro- ducing Moraxella by use of a continous – culturebiofilm system // Antimicrob. Agents Chemother. 1998. Vol. 43. P. 2521–2526.
20. Burton E., Gawande P.V., Yakandawala N. et al. Anti- biofilm activity of GlmU enzyme inhibitors against catheter-associated uropathogens // Antimicrob Agents Chemother. 2006. Vol. 50. P. 1835–1840.
21. Carson L., Gorman S.P., Gilmore B.F. The use of lytic bacteriophages in the prevention and eradication of bio- films of Proteus mirabilis and Escherichia coli // FEMS Immunol Med Microbiol. 2010. Vol. 59 (3). P. 447–455.
22. Ciofu O. Pseudomonas aeruginosa chromosomal beta- lactamase in patiens with cystic fibrosis and chronic lung infection. Mechanism of antibiotic resistance and target of the humoral immune response // APMIS Suppl. 2003. Vol. 116. P. 41–47.
23. Costerton J.W., Stewardm P.S., Greenberg E.P. Bacterial biofilms: a common cause of persistent infections // Sci- ence. 1999. Vol. 284. P. 1318–1322.
24. Cotar A.I., Dinu S., Chifiriuc M.C. et al. Screening of molecular markers of quorum sensing in Pseudomonas aeruginosa strains isolated from clinical infections // Roum. Biotech. Letters. 2008. Vol. 13 (3). P. 3765–3770.
25. Curtin J.J., Donlan R.M. Using bacteriophages to redu- ce formation of catheter-associated biofilms by Staphy- lococcus epidermidis // Antimicrob Agents Chemother. 2006. Vol. 50. P. 1268–1275.
26. Davey M.E., O’Toolem G.A. Microbial biofilms: from ecology to molecular genetics // Microbiol. Mol. Biol. Rev. 2000. Vol. 64. P. 847–867.
27. Davies D.G., Chakrabarty A.M., Geesey G.G. Exopoly- saccharide production in biofilms: substratum activation of alginate gene expression by Pseudomonas aerugino- sa // Appl. Environ. Microbiol. 1993. Vol. 59. P. 1181– 1186.
28. Davies D.G., Marques C.N.H. A fatty acid messenger is responsible for inducing dispersion in microbial bio- films // J. Bacteriol. 2009. Vol. 191. P. 1393–1403.
29. Donelli G. Vascular catheter-related infection and sep- sis // Surg Infect (Larchmt). 2006. Vol. 7 (Suppl 2). S. 5–7.
30. Donlan R.M., Costerton J.W. Biofilms: survival mecha- nisms of clinically relevant microorganisms // Clin. Mi- robiol. Rev. 2002. Vol. 15. P. 167–193.
31. Donlan R.M. Biofilm elimination on intravascular ca- theters: important consideration for the infectious di- sease practitioner // Healthcare epidemiology. 2011. Vol. 52 (15). P. 1038–1043.
32. Dunne W.M., Mason E.O., Kaplan S.L. Diffusion of ri- fampin and vancomicin through a Staphylococcus epi- dermidis biofilms // Antimicrob. Agents Chemoter. 1993. Vol. 37. P. 2522–2526.
33. Estivill D., Arias A., Torres-Lana A. et al. Biofilm formati- on by five species of Candida on three clinical materials // J. Microbiol. Methods. 2011. Vol. 86 (2). P. 238–242.
34. Hall-Stoodley L.J., Costerton W., Stoodley P. Bacterial biofilms: from the natural environment to infectious di- seases // Nat. Rev. Microbiol. 2004. Vol. 2. P. 95–108.
35. Hentzer M., Teitzel G.M., Balzer G.J. et al. Alginate overproduction affects Pseudomonas aeruginosa bio- film structure and function // J. Bacteriol. 2001. Vol. 183. P. 5395–5401.
36. Holmberg A., Morgelin M., Rasmussen M. Effectiveness of ciprofloxacin or linezolid in combination with rifam- picin against Enterococcus faecalis in biofilms // J. Anti- microb. Chemoter. 2012. Vol. 67 (2). P. 433–439.
37. Keren I., Shah D., Spoering A. et al. Specialized persister cells and the mechanism of multidrug tolerance in Esche- richia coli // J. Bacteriol. 2004. Vol. 186. P. 8171–8180.
38. Khardori N., Yassien M. Biofilms in device-related infec- tions // J. Ind. Microbiol. 1995. Vol. 15 (3). P. 141–147.
39. Lazar V., Chifiriuc M.C. Architecture and physiology of microbial biofilms // Roum Arch Microbiol Immunol. 2010. Vol. 69 (2). P. 95–107.
40. Lazar V., Chifiriuc M.C. Medical significance and new therapeu tial strategies for biofilm associated infections // Roum Arch. Microbiol. Immunol. 2010. Vol. 69 (3). P. 125–138.
41. Mandsberg L.F., Ciofu O., Kirkby N. et al. Antibiotic re- sistance in Pseudomonas aeruginosa strains with incre- ased mutation frequency due to inactivation of the DNA oxidative repair system // Antimicrob. Agents Chemoter. 2009. Vol. 53. P. 2483–2491.
42. Metcalf S.C.L., Chambers S.T., Pithie A.D. Use of etha- nol locks to prevent recurrent central line sepsis // J. In- fect. 2004. Vol. 49. P. 20–22.
43. Nablo B.J., Prichard H.L., Butler R.D. et al. Inhibition of implant-associated infections via nitric oxide release // Biomaterials. 2005. Vol. 26. P. 6984–6990.
44. Percival S.L., Kite P., Eastwood K. et al. Tetrasodium EDTA as a novel central venous catheter lock soluti- on against biofilm // Infect. Control. Hosp. Epidemiol. 2005. Vol. 26. P. 515–519.
45. Raad I., Chatzinikolaou I., Chaiban G. et al. In vitro and ex vivo activities of minocycline and EDTA against mi- croorganisms embedded in biofilm on catheter surfaces // Antimicrob. Agents Chemother. 2003. Vol. 47 (11). P. 3580–3585.
46. Raad I.I., Fang X., Keutgen X.M. The role of chelators in preventing biofilm formation and catheter-related bloodstream infections // Curr. Opin. Infect. Dis. 2008. Vol. 21. P. 385–392.
47. Sha C.B., Mittelman M.W., Costerton J.W. et al. Antimi- crobial activity of a novel catheter lock solution // Anti- microb. Agents Chemother. 2002. Vol. 46. P. 1674–1679.
48. Simon A., Ammann R.A., Wiszniewsky G. et al. Tauroli- dine-citrate lock solution (TauroLock) significantly re- duces CVAD-associated gram positive infections in pe- diatric cancer patients // BMC Infect. Dis. 2008. Vol. 8. P. 102.
49. Street C.N., Gibbs A., Pedigo L. et al. In vitro photody- namic eradication of Pseudomonas aeruginosa in plank- tonic and biofilm culture // Photochem. Photobiol. 2009. Vol. 85 (1). P. 137–143.
50. Yu J., Wu J., Francis K.P. et al. Monitoring in vivo fitness of rifampicin-resistant Staphylococcus aureus mutants in a mouse biofilm infection model // J. Antimicrob. Che- mother. 2005. Vol. 55. P. 528–534.
Review
For citations:
Gabrielyan N.I., Gorskaya E.M., Romanova N.I., Tsirulnikova O.M. NOSOCOMIAL INFECTION AND MICROBIAL BIOFILMS IN SURGERY. Russian Journal of Transplantology and Artificial Organs. 2012;14(3):83-91. (In Russ.) https://doi.org/10.15825/1995-1191-2012-3-83-91
Views:
956
Email this article 