MEDICAMENTAL IMMUNOSUPRESSION IN EARLY AGE PEDIATRIC LIVER RECIPIENTS
https://doi.org/10.15825/1995-1191-2012-3-77-82
Abstract
The article presents analysis of scientific literature of the last 20 years about medicamental immunosupression in early age pediatric liver recipients in view of immune response characteristics and immunosuppressive drugs pharmacokinetics in such patients. The modern concept of immunosuppressive therapy protocol choice in pedia- tric liver recipients depending on complications development (nephrotoxicity, arterial hypertension and neuroto- xicity, the high risk of infectious complications, post-transplant proliferative disorders, metabolic and cosmetic side effects) is presented. Different opportunities of early steroid withdrawal, calcineurin inhibitor minimization in pediatric liver allograft recipients are covered.
About the Authors
S. V. Gautier
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
D. S. Mnatsakanyan
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
References
1. Галактионов В.Г. Механизмы иммунитета в графи- ческой форме. М.: Медицина, 2000.
2. Готье С.В. Ортотопическая трансплантация печени в лечении ее диффузных и очаговых заболеваний: Дис. ... докт. мед. наук. М., 1996. 346 с.
3. Готье С.В., Баранов А.А., Каганов Б.С. Транспланта- ция печени у детей: состояние проблемы // Россий- ский педиатрический журнал. 2003. No 1. С. 39–44.
4. Готье С.В., Попцов В.Н., Пчельников В.В. и др. Ане- стезиологическое обеспечение родственной транс- плантации печени у детей в возрасте до 2 лет // Ма- териалы III международной конференции «Проблема безопасности в анестезиологии». 2009. С. 11.
5. Ройт А., Бростофф Дж., Мейл Д. Иммунология. М.: Мир, 2000.
6. Agarwal A., Pescovitz M.D. Immunosupression in pedi- atric solid organ transplantation // Semin Pediatr Surg. 2006 Aug. Vol. 15 (3). P. 142–152.
7. Aw M.M., Samaroo B., Baker A.J. et al. Calcineurin- inhibitor related nephrotoxicity–reversibility in paedia- tric liver transplant recipients // Transplantation. 2001. Vol. 72. P. 746–749.
8. Belghiti J., Panis Y., Sauvanet A. et al. A new technique of side to side cava anastomosis during orthotopic hepa- tic transplantation without inferior vena cava occlusion //Surgery, Gynecology and Obstetrics. 1992. Vol. 175.
9. P. 270–272.
10. Bismuth H., Farges O., Samuel D. et al. Past, present
11. and future in liver transplantation immunosuppression //
12. Transplantation Proceedings. 1992. Vol. 24 (4). P. 85–87.
13. Calne R.Y., White D.J., Evans D.B. et al. Cyclosporin A in cadaveric organ transplantation // British Medical
14. Journal. 1981. Vol. 282. P. 934–936.
15. Ganschow R., Grabhorn E., Schulz A. et al. Long-term
16. results of basiliximab induction immunosuppression in pediatric liver transplant recipients // Pediatr. Transplant. 2005. Vol. 9. P. 741–745.
17. GrasJ.M.,GerkensS.,BeguinC.etal.Steroid-free,tacro- limus- basiliximab immunosuppression in pediatric liver transplantation: Clinical and pharmacoeconomic study in 50 children // Liver Transpl. 2008. Vol. 14. P. 469–477.
18. Magliocca J.F., Knechtle S.J. The evolving role of alem- tuzumab (Campath-1H) for immunosuppressive therapy in organ transplantation // Transpl Int. 2006. Vol. 19. P. 705–714.
19. McDiarmid S.V. Special considerations for Pediatric Im- munosuppression after liver transplantation // Transplan- tation of liver / [edited by] R.W. Busuttil, G.B. Klint- malm. 2nd ed. 2005. P. 1235–1263.
20. McDiarmid S.V., Anand R., Lindblad A.S. SPLIT Re- search Group: Studies of pediatric liver transplantation: 2002 update. An overview of demographics, indications, timing, and immunosuppressive practices in pediatric liver transplantation in rhe United States and Canada // Pediatr. Transpl. 2004. Vol. 8. P. 284–294.
21. McDiarmid S.V., Busuttil R.W., Ascher N.L. et al. FK506 (tacrolimus) compared with cyclosporine for primary immunosuppression after pediatric liver transplantation. Results from the U.S. Multicenter Trial // Transplantati- on. 1995. Vol. 59. P. 530–536.
22. Reding R., Gras J., Sokal E. et al. Steroid free liver trans- plantation in children // Lancet. 2003. Vol. 362. P. 2068– 2070.
23. Shepherd R.W., Turmelle Y., Nadler M. et al. Risk factors for rejection and infection in pediatric liver transplantati- on // Am. J. Transplant. 2008. Vol. 8. P. 396–403.
24. Turmelle Y.P., Nadler M.L., Anderson C.D. et al. To- wards minimizing immunosuppression in pediatric liver transplant recipients // Pediatr. Transplantation. 2009. Vol. 13. P. 553–559.
25. Vo Thi Diem H., Sokal E., Janssen M. et al. Steroid with- drawal after pediatric liver transplantation: a long term follow-up study in 109 recipients // Transplantation. 2003. Vol. 75 (10). P. 1664–1670.
Review
For citations:
Gautier S.V., Mnatsakanyan D.S. MEDICAMENTAL IMMUNOSUPRESSION IN EARLY AGE PEDIATRIC LIVER RECIPIENTS. Russian Journal of Transplantology and Artificial Organs. 2012;14(3):77-82. (In Russ.) https://doi.org/10.15825/1995-1191-2012-3-77-82
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