Clinical case of recurrent aHUS after allogeneic cadaveric kidney transplantation
https://doi.org/10.15825/1995-1191-2023-4-80-85
Abstract
Introduction. Atypical hemolytic uremic syndrome (aHUS) is a systemic orphan disease that reproduces as an uncontrolled activation of the alternative pathway of the complement system and is expressed as systemic thrombotic microangiopathy (TMA). The classical triad of aHUS symptoms are hemolytic anemia, thrombocytopenia, and acute kidney injury (AKI). Currently, diagnosis of aHUS is a diagnosis of exclusion and has no pathognomonic features. It is established based on the clinical presentation of the disease after excluding other forms of TMA,
Objective: to increase physicians’ awareness of this rare disease, the diagnosis and treatment of aHUS using a clinical case study.
Conclusion. Early diagnosis of aHUS is extremely important, as timely targeted therapy can significantly improve or completely restore the functions of the affected organ.
About the Authors
S. V. Popov
St. Luke’s Clinical Hospital; Kirov Military Medical Academy
Russian Federation
Russian Federation
St. Petersburg
A. M. Esayan
Pavlov University
Russian Federation
Russian Federation
St. Petersburg
R. G. Guseynov
St. Luke’s Clinical Hospital; St. Petersburg State University
Russian Federation
Russian Federation
St. Petersburg
I. N. Orlov
St. Luke’s Clinical Hospital
Russian Federation
Russian Federation
St. Petersburg
E. V. Lomonosova
St. Luke’s Clinical Hospital
Russian Federation
Russian Federation
St. Petersburg
V. V. Perepelitsa
St. Luke’s Clinical Hospital
Russian Federation
Russian Federation
St. Petersburg
О. A. Vorobyeva
National Center for Clinical Morphological Diagnostics
Russian Federation
Russian Federation
St. Petersburg
A. V. Sadovnikova
St. Luke’s Clinical Hospital
Russian Federation
Russian Federation
St. Petersburg
T. A. Lelyavina
St. Luke’s Clinical Hospital; Almazov National Medical Research Centre
Russian Federation
Russian Federation
Tatiana Lelyavina
2, Akkuratova str., St. Petersburg, 197341
Phone: (981) 908-90-18
References
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Supplementary files
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For citations:
Popov S.V., Esayan A.M., Guseynov R.G., Orlov I.N., Lomonosova E.V., Perepelitsa V.V., Vorobyeva О.A., Sadovnikova A.V., Lelyavina T.A. Clinical case of recurrent aHUS after allogeneic cadaveric kidney transplantation. Russian Journal of Transplantology and Artificial Organs. 2023;25(4):80-85. https://doi.org/10.15825/1995-1191-2023-4-80-85
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