Asystole kidney donation using automated chest compression system and hypothermic oxygenated machine perfusion (first experience in the Russian Federation)

Objective: to demonstrate, using a clinical case, the first successful experience in a combined use of an automated chest compression device (ACCD) and hypothermic oxygenated machine perfusion (HOPE) for kidney transplantation from a donor with irreversible cardiopulmonary arrest. Materials and methods. In the presented clinical case, ACCD was successfully used in a donor who was pronounced dead following an irreversible cardiopulmonary arrest. This allowed to minimize the primary warm ischemia time. Kidney graft HOPE for 585 minutes reduced the static cold storage time to 165 minutes. Results. In the uneventful postoperative period, there was immediate kidney graft function. This allowed for rapid rehabilitation and discharge from hospital. Conclusion. Introduction of ACCD and HOPE will increase the number of donor organs, mainly kidneys intended for transplantation.

1. Lomero M, Gardiner D, Coll E, Haase-Kromwijk B, Procaccio F, Immer F et al. Donation after circulatory death today: an updated overview of the European landscape. Transplant International. 2020; 33 (1): 76–88. https://doi.org/10.1111/tri.13506.

2. Domínguez-Gil B, Duranteau J, Mateos A, Núñez JR, Cheisson G, Corral E et al. Uncontrolled donation after circulatory death: European practices and recommendations for the development and optimization of an effective programme. Transplant International. 2016; 29 (8): 42–859. https://doi.org/10.1111/tri.12734.

3. Miranda-Utrera N, Medina-Polo J, Pamplona M, de la Rosa F, Rodríguez A, Duarte JM et al. Donation after cardiac death: results of the SUMMA 112 – Hospital 12 de Octubre Program. Clin Transplant. 2013; 27: 283. https://doi.org/10.1111/ctr.12071.

4. Hoogland ER, van Smaalen TC, Christiaans MH, van Heurn LW. Kidneys from uncontrolled donors after cardiac death: which kidneys do worse? Transpl Int. 2013; 26: 477–484. https://doi.org/10.1111/tri.12067.

5. Hanf W, Codas R, Meas-Yedid V, Berthiller J, Buron F, Chauvet C et al. Kidney graft outcome and quality (after transplantation) from uncontrolled deceased donors after cardiac arrest. Am J Transplant. 2012; 12: 1541–1550. https://doi.org/10.1111/j.1600-6143.2011.03983.x.

6. Fondevila C, Hessheimer AJ, Flores E, Ruiz A, Mestres N, Calatayud D et al. Applicability and results of Maastricht type 2 donation after cardiac death liver transplantation. Am J Transplant. 2012; 12: 162–170. https://doi.org/10.1111/j.1600-6143.2011.03834.x.

7. Kron P, Schlegel A, de Rougemont O, Oberkofler CE, Clavien PA, Dutkowski P et al. Short, cool, and well oxygenated – HOPE for kidney transplantation in a rodent model. Annals of surgery. 2016; 264 (5): 815–822. https://doi.org/10.1097/SLA.0000000000001766.

8. Gautier SV, Khomyakov SM. Organ donation and transplantation in the Russian Federation in 2020. 13th Report from the Registry of the Russian Transplant Society. Russian Journal of Transplantology and Artificial Organs. 2021; 23 (3): 8–34. https://doi.org/10.15825/1995-1191-2021-3-8-34.

9. Shabunin AV, Parfenov IP, Minina MG, Drozdov PA, Nesterenko IV, Makeev DA et al. Botkin Hospital Transplant Program: 100 solid organ transplantations. Russian Journal of Transplantology and Artificial Organs. 2020; 22 (1): 55–58. [In Russ, English abstract]. https://doi.org/10.15825/1995-1191-2020-1-55-58.

10. Urbanellis P, Mazilescu L, Kollmann D, Linares-Cervantes I, Kaths JM, Ganesh S et al. Prolonged warm ischemia time leads to severe renal dysfunction of donation-after-cardiac death kidney grafts. Scientific Reports. 2021; 11 (1): 1–11. https://doi.org/10.1038/s41598-021-97078-w.