PERSPECTIVES OF ANTISENSE GENE THERAPY IN ORGAN TRANSPLANTATION
https://doi.org/10.15825/1995-1191-2013-1-106-117
Abstract
Global organ shortage is the crucial point of transplantation nowadays. Usage of expanded criteria donors represents reliable source of donor organs, making transplantation more accessible for patients with end stage organs failure. Ischemia-reperfusion injury followed by the activation of programmed cell death scenarios remains the main obstacle in utilization of marginal grafts. Programmed cell death often leads to life threatening complications in posttransplant period. Antisense gene therapy could provide a therapeutic tool, capable to improve quality of grafts and, consequently, transplantation outcomes.
About the Authors
O. N. Reznik
St. Petersburg State Medical University named after Academician I.P. Pavlov
A. E. Skvortsov
St. Petersburg State Medical University named after Academician I.P. Pavlov
D. O. Kuzmin
St. Petersburg State Medical University named after Academician I.P. Pavlov
A. P. Tutin
St. Petersburg State Medical University named after Academician I.P. Pavlov
A. O. Reznik
St. Petersburg State Medical University named after Academician I.P. Pavlov
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For citations:
Reznik O.N., Skvortsov A.E., Kuzmin D.O., Tutin A.P., Reznik A.O. PERSPECTIVES OF ANTISENSE GENE THERAPY IN ORGAN TRANSPLANTATION. Russian Journal of Transplantology and Artificial Organs. 2013;15(1):106-117. (In Russ.) https://doi.org/10.15825/1995-1191-2013-1-106-117
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