ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ АНТИСМЫСЛОВОЙ ГЕННОЙ ТЕРАПИИ ПРИ ТРАНСПЛАНТАЦИИ ОРГАНОВ
https://doi.org/10.15825/1995-1191-2013-1-106-117
Аннотация
Главной проблемой трансплантологии остается дефицит донорских органов. Использование для транс- плантации органов, полученных от доноров с расширенными критериями, позволяет расширить донор- ский пул, увеличивая доступность трансплантации нуждающимся в ней пациентам с терминальными стадиями болезней внутренних органов. Основным препятствием к широкому использованию доноров с расширенными критериями является ишемическое повреждение, следующая за ним ишемически- реперфузионная травма органов, активация сценариев программируемой клеточной гибели, приводящие к снижению функционального резерва трансплантатов, а зачастую к развитию тяжелых осложнений в послеоперационном периоде. Применение антисмысловой генной терапии при трансплантации может послужить терапевтическим инструментом, позволяющим влиять на трансплантат на всех этапах работы с ним, улучшая его качество, и следовательно, результат трансплантации.
Об авторах
О. Н. Резник
ГБОУ ВПО «СПбГМУ им. акад. И.П. Павлова», Санкт-Петербург
А. Е. Скворцов
ГБОУ ВПО «СПбГМУ им. акад. И.П. Павлова», Санкт-Петербург
Д. О. Кузьмин
ГБОУ ВПО «СПбГМУ им. акад. И.П. Павлова», Санкт-Петербург
А. П. Тутин
ГБОУ ВПО «СПбГМУ им. акад. И.П. Павлова», Санкт-Петербург
А. О. Резник
ГБОУ ВПО «СПбГМУ им. акад. И.П. Павлова», Санкт-Петербург
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Рецензия
Для цитирования:
Резник О.Н., Скворцов А.Е., Кузьмин Д.О., Тутин А.П., Резник А.О. ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ АНТИСМЫСЛОВОЙ ГЕННОЙ ТЕРАПИИ ПРИ ТРАНСПЛАНТАЦИИ ОРГАНОВ. Вестник трансплантологии и искусственных органов. 2013;15(1):106-117. https://doi.org/10.15825/1995-1191-2013-1-106-117
For citation:
Reznik O.N., Skvortsov A.E., Kuzmin D.O., Tutin A.P., Reznik A.O. PERSPECTIVES OF ANTISENSE GENE THERAPY IN ORGAN TRANSPLANTATION. Russian Journal of Transplantology and Artificial Organs. 2013;15(1):106-117. (In Russ.) https://doi.org/10.15825/1995-1191-2013-1-106-117
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