IMPACT OF SEVOFLURANE AND ACETYLCYSTEINE ON ISCHEMIA-REPERFUSION INJURY OF THE LIVER FROM BRAIN-DEAD DONOR
https://doi.org/10.15825/1995-1191-2013-1-39-44
Abstract
Aim. The purpose of our work was to estimate the impact of preconditioning with acetylcysteine and sevoflurane on ischemia-reperfusion injury of cadaveric donor liver with marginal features. Methods and results. In this prospective randomized controlled trial we recruited 21 heart beating donors with brain death. We assigned 11 donors to the study group, and 10 donors to the control group. Morphological characteristics of ischemia- reperfusion injury in both groups were analyzed. Conclusion. Use of pharmacological preconditioning with acetylcysteine and sevoflurane resulted in necrosis and hepatocyte apoptosis reduction as compared to the control group, thereby had a protective effect against ischemia-reperfusion injury.
About the Authors
A. E. Shcherba
Republican Research and Practice Centre «Tissue and Organ Transplantation», Minsk State Clinical Hospital No 9
S. V. Korotkov
Republican Research and Practice Centre «Tissue and Organ Transplantation», Minsk State Clinical Hospital No 9
A. F. Minov
Republican Research and Practice Centre «Tissue and Organ Transplantation», Minsk State Clinical Hospital No 9
Y. V. Slobodin
Republican Research and Practice Centre «Tissue and Organ Transplantation», Minsk State Clinical Hospital No 9
M. M. Savchuk
Belarusian Medical Academy of Postgraduate Education, Minsk, Republic of Belarus
A. M. Dzyadzko
Republican Research and Practice Centre «Tissue and Organ Transplantation», Minsk State Clinical Hospital No 9
O. O. Rummo
Republican Research and Practice Centre «Tissue and Organ Transplantation», Minsk State Clinical Hospital No 9
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Review
For citations:
Shcherba A.E., Korotkov S.V., Minov A.F., Slobodin Y.V., Savchuk M.M., Dzyadzko A.M., Rummo O.O. IMPACT OF SEVOFLURANE AND ACETYLCYSTEINE ON ISCHEMIA-REPERFUSION INJURY OF THE LIVER FROM BRAIN-DEAD DONOR. Russian Journal of Transplantology and Artificial Organs. 2013;15(1):39-44. (In Russ.) https://doi.org/10.15825/1995-1191-2013-1-39-44
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