BONE TURNOVER AND MINERAL DENSITY OF THE LUMBAR VERTEBRAE IN WOMEN WITH PRIMARY BILIARY CIRRHOSIS BEFORE AND AFTER ORTHOTOPIC LIVER TRANSPLANTATION
https://doi.org/10.15825/1995-1191-2013-1-21-30
Abstract
Aim. To elucidate the role of cholestasis and menopausal status in the development of osteoporosis in women with primary biliary cirrhosis (PBC) before and after orthotopic liver transplantation (OLT). Methods and re- sults. There were fulfilled 74 estimations of biochemical markers of bone metabolism, estrogen (E2), parathy- roid hormone (PTH) endogenous secretion so as mineral content of lumbar vertebras in 21 women with PBC (10 women before and 17 in different terms after OLT). Bone turnover disturbances were characterized by delay of bone formation associated with hyperbilirubinaemia before OLT while increased bone turnover following OLT. Bone resorption markers correlated inversely with E2 in postmenopausal women and positively with PTH in premenopausal women. Conclusion. Bone wastes degree depended on hard and duration of disease before OLT so as menopausal status after OLT. In postmenopausal women bone wastes were associated with degree of endogenous E2 decreasing, increased bone turnover, and graft dysfunction.
About the Authors
I. A. Pronchenko
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
I. P. Ermakova
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Y. G. Moysyuk
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
I.M. Sechenov First Moscow State Medical University, Department of Transplantology and Artificial Organs, Moscow
V. P. Buzulina
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
N. P. Shmerko
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
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For citations:
Pronchenko I.A., Ermakova I.P., Moysyuk Y.G., Buzulina V.P., Shmerko N.P. BONE TURNOVER AND MINERAL DENSITY OF THE LUMBAR VERTEBRAE IN WOMEN WITH PRIMARY BILIARY CIRRHOSIS BEFORE AND AFTER ORTHOTOPIC LIVER TRANSPLANTATION. Russian Journal of Transplantology and Artificial Organs. 2013;15(1):21-30. (In Russ.) https://doi.org/10.15825/1995-1191-2013-1-21-30
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