Клетки Сертоли: иммуномодулирующие свойства, способы выделения и культивирования
https://doi.org/10.15825/1995-1191-2021-3-142-147
Аннотация
В связи с осложнениями, обусловленными неизбежным применением иммуносупрессивных препаратов при трансплантации органов и клеток, вызывает интерес использование естественных механизмов обеспечения иммунологической толерантности, выявленных в организмах животных и человека. Давно известно, что в них имеются определенные области, в том числе семенник, где иммунные реакции практически невозможны. В настоящем обзоре основное внимание уделено роли клеток Сертоли, обеспечивающих иммунопривилегированность семенника. Описываются способы изоляции и культивирования клеток Сертоли и обсуждаются возможности их использования в биологии и медицине.
Об авторах
Н. Н. Скалецкий
ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России
Россия
Россия
Скалецкий Николай Николаевич, главный специалист
123182, Москва, ул. Щукинская, д. 1
Г. Н. Скалецкая
ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России
Россия
Россия
Скалецкая Галина Николаевна
Москва
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Рецензия
Для цитирования:
Скалецкий Н.Н., Скалецкая Г.Н. Клетки Сертоли: иммуномодулирующие свойства, способы выделения и культивирования. Вестник трансплантологии и искусственных органов. 2021;23(3):142-147. https://doi.org/10.15825/1995-1191-2021-3-142-147
For citation:
Skaletskiy N.N., Skaletskaya G.N. Sertoli cells: immunomodulatory properties, methods of isolation and culture. Russian Journal of Transplantology and Artificial Organs. 2021;23(3):142-147. https://doi.org/10.15825/1995-1191-2021-3-142-147
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