HEART TRANSPLANTATION WITH EXTREMELY EXTENDED COLD ISCHEMIA TIME OF THE DONOR HEART
https://doi.org/10.15825/1995-1191-2018-1-110-113
Abstract
Heart transplantation is the gold standard for the treatment of terminal heart failure. The main method of the donor heart preservation is cold perfusion. The recommended maximum time for cold ischemia of the donor heart is 240 minutes. Exceeding this safe limit increases the risk of postoperative allograft dysfunction and death. However, there are reports positing a possibility to prolong the time of ischemia of the donor heart without a signifi cant risk of complications. The article presents the experience of successful transplantation of the donor heart with the cold ischemia time was 440 minutes.
About the Authors
S. A. Alsov
Meshalkin National Medical Research Center, Ministry of Health of Russian Federation
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
A. V. Fomichev
Meshalkin National Medical Research Center, Ministry of Health of Russian Federation
Russian Federation
Russian Federation
Fomichev Alexsey Vyacheslavovich
15, Rechkunovskaya st., Novosibirsk, 630055
D. V. Doronin
Meshalkin National Medical Research Center, Ministry of Health of Russian Federation
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
V. A. Shmyrev
Meshalkin National Medical Research Center, Ministry of Health of Russian Federation
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
D. E. Osipov
Meshalkin National Medical Research Center, Ministry of Health of Russian Federation
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
A. M. Chernyavskiy
Meshalkin National Medical Research Center, Ministry of Health of Russian Federation
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
References
1. Bui AL, Horwich TB, Fonarow GC. Epidemiology and risk profi le of heart failure. Nat. Rev. Cardiol. 2011; 8: 30–41. doi:10.1038/nrcardio.2010.165.
2. Chernyavskiy AM, Efendiev VU, Sirota DA, Alyapkina EM, Efanova OS. Izmenenie kachestva zhizni bol’nyh ishemicheskoi bolezn’ju serdca s vyrazhennoj disfunkciej levogo zheludochka posle hirurgicheskoj revaskuljarizacii miokarda. Patologiya krovoobrashcheniya i kardiokhirurgiya = Circulation Pathology and Cardiac Surgery. 2014; 18 (2): 22–26. doi: http://dx.doi.org/10.21688/1681-3472-2014-2-22-26 [In Russ].
3. Abouna GM. Organ shortage crisis: problems and possible solutions. Transplant Proc. 2008; Jan-Feb; 40 (1): 34–38. doi: 10.1016/j.transproceed.2007.11.067.
4. Erasmus M, Neyrink A, Sabatino M, Potena L. Heart allograft preservation: an arduous journey from the donor to the recipient. Curr Opin Cardiol. 2017; Feb 24. doi: 10.1097/HCO.0000000000000395.
5. Bourge RC, Naftel DC, Costanzo-Nordin MR, Kirklin JK, Young JB, Kubo SH et al. Pretransplantation risk factors for death after heart transplantation: a multiinstitutional study. The Transplant Cardiologists Research Database Group. J. Heart. Lung. Transplant. 1993; JulAug; 12 (4): 549–562.
6. Fernandez J, Aranda J, Mabbot S, Weston M, Cintron G. Overseas procurement of donor hearts: ischemic time effect on postoperative outcomes. Transplant. Proc. 2001; Nov-Dec; 33 (7–8): 3803–3804. doi: 10.1016/S00411345(01)02610-0.
7. Mitropoulos FA, Odim J, Marelli D, Karandikar K, Gjertson D, Ardehali A et al. Outcome of hearts with cold ischemic time greater than 300 minutes. A casematched study. Eur. J. Cardiothorac. Surg. 2005; Jul; 28 (1): 143–148. doi: 10.1016/j.ejcts.2005.01.067.
8. Briganti EM, Bergin PJ, Rosenfeldt FL, Esmore DS, Rabinov M. Successful long-term outcome with prolonged ischemic time cardiac allografts. J. Heart. Lung. Transplant. 1995; Sep-Oct; 14 (5): 840–845.
9. Morgan JA, John R, Weinberg AD, Kherani AR, Colletti NJ, Vigilance DW et al. Prolonged donor ischemic time does not adversely affect long-term survival in adult patients undergoing cardiac transplantation. J. Thorac. Cardiovasc. Surg. 2003; Nov; 126 (5): 1624– 1633.
10. Del Rizzo DF, Menkis AH, Pfl ugfelder PW, Novick RJ, McKenzie FN, Boyd WD et al. The role of donor age and ischemic time on survival following orthotopic heart transplantation. J. Heart. Lung. Transplant. 1999; Apr; 18 (4): 310–319.
11. Russo MJ, Chen JM, Sorabella RA, Martens TP, Garrido M, Davies RR et al. The effect of ischemic time on survival after heart transplantation varies by donor age: an analysis of the United Network for Organ Sharing database. J. Thorac. Cardiovasc. Surg. 2007; Feb; 133 (2): 554–559.
12. Hicks M, Hing A, Gao L, Ryan J, Macdonald PS. Organ preservation. Methods Mol. Biol. 2006; 333: 331–374. doi: 10.1385/1-59745-049-9:331.
13. Lowalekar SK, Cao H, Lu XG, Treanor PR, Thatte HS. Sub-normothermic preservation of donor hearts for transplantation using a novel solution, Somah: a comparative pre-clinical study. J. Heart. Lung. Transplant. 2014; Sep; 33 (9): 963–970. doi: 10.1016/j.healun.2014.05.006.
14. Lowalekar SK, Lu XG, Thatte HS. Further evaluation of Somah: long-term preservation, temperature effect, and prevention of ischemia-reperfusion injury in rat hearts harvested after cardiocirculatory death. Transplant. Proc. 2013; 45: 3192–3197.
15. Jacobs S, Rega F, Meyns B. Current preservation technology and future prospects of thoracic organs. Part 2: heart. Curr. Opin. Organ. Transplant. 2010; Apr; 15 (2): 156–159. doi: 10.1097/MOT.0b013e328337343f.
16. Obadia JF, Girard C, Ferrara R, Chuzel M, Chassignolle JF, Dureau G. Long conservation organs in heart transplantation: postoperative results and long-term followup in fourteen patients. J. Heart. Lung. Transplant. 1997; Feb; 16 (2): 256–259.
Review
For citations:
Alsov S.A., Fomichev A.V., Doronin D.V., Shmyrev V.A., Osipov D.E., Chernyavskiy A.M. HEART TRANSPLANTATION WITH EXTREMELY EXTENDED COLD ISCHEMIA TIME OF THE DONOR HEART. Russian Journal of Transplantology and Artificial Organs. 2018;20(1):110-113. (In Russ.) https://doi.org/10.15825/1995-1191-2018-1-110-113
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