In situ crosslinkable hydrogels for engineered cellular microenvironments
https://doi.org/10.15825/1995-1191-2017-3-53-64
Abstract
In situ crosslinkable hydrogels have been widely used as therapeutic implants and vehicles for a broad range of biomedical applications including tissue regenerative medicine because of their biocompatibility and easiness of encapsulation of cells or signaling molecules during hydrogel formation. Recently, these hydrogel materials have been widely utilized as an artificial extracellular matrix (aECM) because of its structural similarity with the native extracellular matrix (ECM) of the human body and its multi-tunable properties. Various synthetic, natural, and semisynthetic hydrogels have been developed as engineered cellular microenvironments by using various crosslinking strategies. In this review, we discuss how in situ forming hydrogels are being created with tunable physical, chemical, and biological properties. In particular, we focus on emerging techniques to apply advanced hydrogel materials for engineered cellular microenvironments.
About the Authors
Kyung Min Park
Incheon National University
Korea, Republic of
Korea, Republic of
Division of Bioengineering, College of Life Sciences and Bioengineering
Incheon 22012, Republic of Korea
Ki Dong Park
Ajou University
Korea, Republic of
Korea, Republic of
Department of Molecular Science and Technology
Suwon 443-749, Republic of Korea
V. I. Sevastianov
V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
E. A. Nemetz
V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
V. N. Vasilets
V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Park K.M., Park K.D., Sevastianov V.I., Nemetz E.A., Vasilets V.N. In situ crosslinkable hydrogels for engineered cellular microenvironments. Russian Journal of Transplantology and Artificial Organs. 2017;19(3):53-64. (In Russ.) https://doi.org/10.15825/1995-1191-2017-3-53-64
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