Exp erimental research of wearable artificial kidney
https://doi.org/10.15825/1995-1191-2017-3-46-52
Abstract
Aim. The article presents the results of wearable artificial kidney (WAK) biomedical trial based on peritoneal dialysis with continuous dialysate regeneration.
Materials and methods. The trial was carried out on a 15-kg dog. First stage: dialysis was carried out on healthy dog to evaluate effect of WAK on blood biochemical indicators. Second stage: 200 ml of X-ray contrast agent was injected into dog’s bloodstream to simulate acute kidney failure.
Results. During trial (39.5 hours) WAK was performing continuous peritoneal dialysis with dialysis fluid regeneration. During second stage (34 hours) creatinine and uric acid were eliminated from dialysis solution at the rate of 0.3 mg/h, urea was eliminated at the rate of 0.15 g/h, total removed ultrafiltrate volume was 350 ml. At the end of the second stage blood biochemical indicators stabilised in the range of normal values.
Conclusion. Developed WAK can perform continuous blood purification and ultrafiltration with no pathologic impact on blood biochemical indicators.
About the Authors
N. A. Bazaev
National Research University of Electronic Technology «MIET»
Russian Federation
Russian Federation
Address: 1, Shokin Sq., Zelenograd, Moscow, 124498, Russian Federation. Тel. (925) 049-14-54
V. M. Grinvald
National Research University of Electronic Technology «MIET»
Russian Federation
Russian Federation
S. V. Selishchev
National Research University of Electronic Technology «MIET»
Russian Federation
Russian Federation
A. V. Kalinov
Tver State Medical University
Russian Federation
Russian Federation
A. V. Kozachuk
Tver State Medical University
Russian Federation
Russian Federation
V. V. Kosatkin
Regional Clinical Hospital
Russian Federation
Russian Federation
F. F. Tyunder
N.A. Semashko Central Clinical Hospital 2 of JSC Russian Railways
Russian Federation
Russian Federation
D. V. Federyakin
Tver State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Bazaev N.A., Grinvald V.M., Selishchev S.V., Kalinov A.V., Kozachuk A.V., Kosatkin V.V., Tyunder F.F., Federyakin D.V. Exp erimental research of wearable artificial kidney. Russian Journal of Transplantology and Artificial Organs. 2017;19(3):46-52. (In Russ.) https://doi.org/10.15825/1995-1191-2017-3-46-52
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