Preview

Russian Journal of Transplantology and Artificial Organs

Advanced search

SOME OF THE MECHANISMS OF EXTRACORPOREAL PHOTOCHEMOTHERAPY IN SOLID ORGAN TRANSPLANTATION

https://doi.org/10.15825/1995-1191-2014-1-76-84

Abstract

Reducing the risk of kidney transplant rejection is a perspective trend in modern medical science. One of the promising methods for reducing the activity of immune conflict between the recipient and the donor organ and the achievement of partial immunological tolerance is photochemotherapy. This method is widely used in over- seas heart and lung Transplantation. Domestic experience of applying this method in renal transplant recipients is extremely small. In this review of literature a modern representation of the scientists on the mechanism of action of this method is presented. 

About the Authors

A. V. Vatazin
Postgraduate Medical M.F. Vladimirsky Moscow Regional Clinical and Research Institute, Moscow, Russian Federation


A. B. Zul'karnaev
Postgraduate Medical M.F. Vladimirsky Moscow Regional Clinical and Research Institute, Moscow, Russian Federation


A. V. Kil'djushevskij
Postgraduate Medical M.F. Vladimirsky Moscow Regional Clinical and Research Institute, Moscow, Russian Federation


V. A. Fedulkina
Postgraduate Medical M.F. Vladimirsky Moscow Regional Clinical and Research Institute, Moscow, Russian Federation


M. Krstic
Postgraduate Medical M.F. Vladimirsky Moscow Regional Clinical and Research Institute, Moscow, Russian Federation


References

1. СПИСОК ЛИТЕРАТУРЫ / REFERENCES

2. MCKenna K.E., Whittaker S., Rhodes L.E., Tailor P., Lloyd J., Ibbson S., Russel-Jones R. Evidence – baced practice of photopheresis 1987 – 2001: a report of a workshop of the British Photodermatology group and the U.K. skin lymphoma group. Br. J. Dermatol. 2006; 154: 7–20.

3. Pierelli L., Perseghin P., Marchetti M., Messina C., Pe- rotti C., Mazzoni A., Bacigalupo A., Locatelli F., Carli- er P., Bosi A. Società Italiana di Emaferesi and Manipo- lazione Cellulare (SIdEM) and Gruppo Italiano Trapianto Midollo Osseo (GITMO). Extracorporeal photopheresis for the treatment of acute and chronic graft-versus-host disease in adults and children: best practice recommen- dations from an Italian Society of Hemapheresis and Cell Manipulation (SIdEM) and Italian Group for Bone Mar- row Transplantation (GITMO) consensus process. Trans- fusion. 2013; 53 (10): 2340–2352.

4. Jaksch P., Scheed A., Keplinger M., Ernst M.B., Dani T., Just U., Nahavandi H., Klepetko W., Knobler R. A pro-

5. spective interventional study on the use of extracorpo- realphotopheresis in patients with bronchiolitis obliter- ans syndrome after lungtransplantation. J. Heart Lung Transplant. 2012; 31 (9): 950–957.

6. Lucid C.E., Savani B.N., Engelhardt B.G., Shah P., Clif- ton C., Greenhut S.L., Vaughan L.A., Kassim A., Schuen- ing F., Jagasia M. Extracorporeal photopheresis in pa- tients with refractory bronchiolitis obliterans developing after allo-SCT. Bone Marrow Transplant. 2011; 46 (3): 426–429.

7. Dall'Amico R., Montini G., Murer L., Andreetta B., Zac- chello G., Gambino A., Feltrin G., Caforio A., Tursi V., Livi U. Extracorporeal photochemotherapy after cardiac transplantation: a new therapeutic approach to allograft rejection. Int. J. Artif. Organs. 2000; 23 (1): 49–54.

8. Marques M.B., Schwartz J. Update on extracorporeal photopheresis in heart and lung transplantation. J. Clin. Apher. 2011; 26 (3): 146–151.

9. Urbani L., Mazzoni A., Colombatto P., Biancofiore G., Bindi L., Tascini C., Menichetti F., Brunetto M., Sca- tena F., Filipponi F. Potential applications of extracor- poreal photopheresis in liver transplantation. Transplant. Proc. 2008; 40 (4): 1175–1178.

10. Urbani L., Mazzoni A., Bianco I., Grazzini T., De Simo- ne P., Catalano G., Montin U., Petruccelli S., Morelli L., Campani D., Pollina L., Biancofiore G., Bindi L., Tas- cini C., Menichetti F., Scatena F., Filipponi F. The role of immunomodulation in ABO-incompatible adult liver transplant recipients. J. Clin. Apher. 2008; 23 (2): 55–62.

11. Kusztal M., Kościelska-Kasprzak K., Gdowska W., Zabińska M., Myszka M., Kłak R., Krajewska M., Boratyńska M., Szyber P., Chudoba P., Patrzałek D., Klinger M. Extracorporeal photopheresis as an antirejec- tion prophylaxis in kidney transplant recipients: prelimi- nary results. Transplant. Proc. 2011; 43 (8): 2938–2940.

12. Scarisbrick J. Extracorporeal photopheresis: what is it and when should it be used? Clin. Exp. Dermatol. 2009; 34 (7): 757–760.

13. Genberg H., Kumlien G., Shanwell A., Tydén G. Refrac- tory acute renal allograft rejection successfully treated with photopheresis. Transplant. Proc. 2005; 37 (8): 3288–3289.

14. Jardine M.J., Bhandari S., Wyburn K.R., Misra A.K., McKenzie P.R., Eris J.M. Photopheresis therapy for problematic renal allograft rejection. J. Clin. Apher. 2009; 24 (4): 161–169.

15. Lai Q., Pretagostini R., Gozzer M., Cinti P., Meo D., Vita F., Bafti M.S., Poli L., Novelli G., Rossi M., Gire- lli G., Berloco P.B. Multimodal treatment for acute an- tibody-mediated renal transplant rejection: successful rescue therapy with combined plasmapheresis, photo- pheresis and intravenous immunoglobulin. G. Ital. Ne- frol. 2012; 29 Suppl 54: S31–35.

16. Benden C., Speich R., Hofbauer G.F., Irani S., Eich- Wanger C., Russi E.W., Weder W., Boehler A. Extracor- poreal photopheresis after lung transplantation: a 10- year single-center experience. Transplantation. 2008; 86 (11): 1625–1627.

17. Morrell M.R., Despotis G.J., Lublin D.M., Patter- son G.A., Trulock E.P., Hachem R.R. The efficacy of photopheresis for bronchiolitis obliterans syndrome after lung transplantation. J. Heart Lung Transplant. 2010; 29 (4): 424–431.

18. Salerno C.T., Park S.J., Kreykes N.S., Kulick D.M., Sa- vik K., Hertz M.I., Bolman R.M. 3rd. Adjuvant treatment of refractory lung transplant rejection with extracorpo- real photopheresis. J. Thorac. Cardiovasc. Surg. 1999; 117 (6): 1063–1069.

19. Villanueva J., Bhorade S.M., Robinson J.A., Husain A.N., Garrity E.R. Jr. Extracorporeal photopheresis for the treatment of lung allograft rejection. Ann. Transplant. 2000; 5 (3): 44–47.

20. Giunti G., Schürfeld K., Maccherini M., Tanganelli P., Rubegni P., Alfani D., D'Ascenzo G., Diciolla F., Bernaz- zali S., Fimiani M., Toscano M., Sani G. Photopheresis for recurrent acute rejection in cardiac transplantation. Transplant. Proc. 1999; 31 (1–2): 128–129.

21. Maccherini M., Diciolla F., Laghi Pasini F., Lisi G., Tan- ganelli P., D'Ascenzo G., Mondillo S., Carone E., Oric- chio L., Baraldi C., Capecchi P.L., Lazzerini P.E., Tosca- no T., Barretta A., Giunti G., Schuerfeld K., Fimiani M., Papalia U. Photopheresis immunomodulation after heart transplantation. Transplant. Proc. 2001; 33 (1–2): 1591– 1594.

22. Barr M.L., Meiser B.M., Eisen H.J., Roberts R.F., Livi U., Dall'Amico R., Dorent R., Rogers J.G., Radovancević B., Taylor D.O., Jeevanandam V., Marboe C.C. Photophere- sis for the prevention of rejection in cardiac transplan- tation. Photopheresis Transplantation Study Group. N. Engl. J. Med. 1998; 339 (24): 1744–51.

23. Kirklin J.K., Brown R.N., Huang S.T., Naftel D.C., Hub- bard S.M., Rayburn B.K., McGiffi n D.C., Bourge R.B., Benza R.L., Tallaj J.A., Pinderski L.J., Pamboukian S.V., George J.F., Marques M. Rejection with hemodynamic compromise: objective evidence for efficacy of photo- pheresis. J. Heart Lung Transplant. 2006; 25 (3): 283– 288.

24. Holtick U., Wang X.N., Marshall S.R., Scheid C., von Bergwelt-Baildon M., Dickinson A.M. In vitro PUVA treatment preferentially induces apoptosis in alloacti- vated T cells. Transplantation. 2012; 94 (5): e31–34.

25. Hannani D., Gabert F., Laurin D., Sall M., Molens J.P., Hequet O., Chaperot L., Plumas J. Photochemotherapy induces the apoptosis of monocytes without impairing their function. Transplantation. 2010; 89 (5): 492–499.

26. Hannani D., Merlin E., Gabert F., Laurin D., De- méocq F., Chaperot L., Kanold J., Plumas J. Photoche- motherapy induces a faster apoptosis of alloreactive ac- tivated T cells than of nonalloreactive resting T cells in graft versus host disease. Transplantation. 2010; 90 (11): 1232–1238.

27. Baron E.D., Heeger P.S., Hricik D.E., Schulak J.A., Tary- Lehmann M., Stevens S.R. Immunomodulatory effect of extracorporeal photopheresis after successful treatment of resistant renal allograft rejection. Photodermatol. Photoimmunol. Photomed. 2001; 17 (2): 79–82.

28. Fimiani M., Di Renzo M., Rubegni P. Mechanism of ac- tion of extracorporeal photochemotherapy in chronic graft-versus-host disease. Br. J. Dermatol. 2004; 150 (6): 1055–1060.

29. Setterblad N., Garban F., Weigl R., Assier E., Drillat P., Charron D., Dickinson A., Greinix H., Mooney N. Extra- corporeal photophoresis increases sensitivity of monocytes from patients with graft-versus-host disease to HLA-DR- mediated cell death. Transfusion. 2008; 48 (1): 169–177.

30. Bains S.K., Mone A., Yun Tso J., Lucas D., Byrd J.C., Weiner G.J., Green J.M. Mitochondria control of cell death induced by anti-HLA-DR antibodies. Leukemia. 2003; 17 (7): 1357–1365.

31. Bladon J., Taylor P. Extracorporeal photopheresis re- duces the number of mononuclear cells that produce pro- inflammatory cytokines, when tested ex-vivo. J. Clin. Apher. 2002; 17 (4): 177–182.

32. Bladon J., Taylor P.C. Lymphocytes treated by extracor- poreal photopheresis can down-regulate cytokine pro- duction in untreated monocytes. Photodermatol. Photo- immunol. Photomed. 2005; 21 (6): 293–302.

33. Ghafari A., Makhdoomi K., Ahmadpour P., Afshari A.T., Lak S.S., Fakhri L. Serum T-lymphocyte cytokines can- not predict early acute rejection in renal transplantation. Transplant. Proc. 2007; 39 (4): 958–961.

34. Holtick U., Wang X.N., Marshall S.R., Scheid C., von Bergwelt-Baildon M., Dickinson A.M. Immature DC isolated after co-culture with PUVA-treated peripheral blood mononuclear cells downregulate graft-versus-host reactions in the human skin explant model. Curr. Stem Cell Res. Ther. 2013; 8 (4): 324–332.

35. del Rio M.L., Buhler L., Gibbons C., Tian J., Rodriguez- Barbosa J.I. PD-1/PD-L1, PD-1/PD-L2, and other co-in- hibitory signaling pathways in transplantation. Transpl. Int. 2008; 21 (11): 1015–1028.

36. Wolnicka-Glubisz A., Fraczek J., Skrzeczynska-Monc- znik J., Friedlein G., Mikolajczyk T., Sarna T., Pryjma J. Effect of UVA and 8-methoxypsoralen, 4, 6, 4'-trimethy- langelicin or chlorpromazine on apoptosis of lympho- cytes and their recognition by monocytes. J. Physiol. Pharmacol. 2010; 61 (1): 107–114.

37. Di Renzo M., Rubegni P., Pasqui A.L., Pompella G., De Aloe G., Sbano P., Cuccia A., Castagnini C., Auteri A., Laghi Pasini F., Fimiani M. Extracorporeal photophere- sis affects interleukin (IL)-10 and IL-12 production by monocytes in patients with chronic graft-versus-host di- sease. Br. J. Dermatol. 2005; 153 (1): 59–65.

38. Peritt D. Potential mechanisms of photopheresis in he- matopoietic stem cell transplantation. Biol. Blood Mar- row Transplant. 2006; 12 (1 Suppl 2): 7–12.

39. Di Renzo M., Sbano P., De Aloe G., Pasqui A.L., Ru- begni P., Ghezzi A., Auteri A., Fimiani M. Extracorporeal photopheresis affects co-stimulatory molecule expres- sion and interleukin-10 production bydendritic cells in graft-versus-host disease patients. Clin. Exp. Immunol. 2008; 151 (3): 407–413.

40. Dhodapkar M.V., Steinman R.M., Krasovsky J., Munz C., Bhardwaj N. Antigen-specific inhibition of effector T cell function in humans after injection of immature den- dritic cells. J. Exp. Med. 2001; 193 (2): 233–238.

41. Dhodapkar M.V., Steinman R.M. Antigen-bearing imma- ture dendritic cells induce peptide-specific CD8(+) regu- latory T cells in vivo in humans. Blood. 2002; 100 (1): 174–177.

42. 40. Spisek R., Gasova Z., Bartunkova J. Maturation state of dendritic cells during the extracorporeal photopheresis and its relevance for the treatment of chronic graft-ver- sus-host disease. Transfusion. 2006; 46 (1): 55–65.

43. Failli A., Legitimo A., Mazzoni A., Urbani L., Scatena F., Mosca F., Consolini R. The combination of immunosup- pressive drugs with 8-methoxypsoralen and ultraviolet a light modulates the myeloid-derived dendritic cell function. Int. J. Immunopathol. Pharmacol. 2011; 24 (1): 89–99.

44. Tan J.K., O'Neill H.C. Maturation requirements for den- dritic cells in T cell stimulation leading to tolerance ver- sus immunity. J. Leukoc. Biol. 2005; 78 (2): 319–324.

45. Usharauli D. Dendritic cells and the immunity/tolerance decision. Med. Hypotheses. 2005; 64 (1): 112–113.

46. Meloni F., Cascina A., Miserere S., Perotti C., Vitulo P., Fietta A.M. Peripheral CD4(+)CD25(+) TREG cell counts and the response to extracorporeal photopheresis in lung transplant recipients. Transplant. Proc. 2007; 39 (1): 213–217.

47. George J.F., Gooden C.W., Guo L., Kirklin J.K. Role for CD4(+)CD25(+) T cells in inhibition of graft rejection by extracorporeal photopheresis. J. Heart Lung Trans- plant. 2008; 27 (6): 616–622.

48. Rubegni P., Sbano P., Cevenini G., Perari M.G., Ma- rotta G., Risulo M., Carcagnì M.R., D' Ascenzo G., De

49. Aloe G., Fimiani M. CD4+CD25+ lymphocyte subsets in chronic graft versus host disease patients undergoing ex- tracorporeal photochemotherapy. Int. J. Immunopathol. Pharmacol. 2007; 20 (4): 801–807.

50. Lamioni A., Carsetti R., Legato A., Landolfo A., Isac- chi G., Emma F., Bottazzo G.F., Dello Strologo L. In- duction of regulatory T cells after prophylactic treatment with photopheresis in renal transplant recipients. Trans- plantation. 2007; 83 (10): 1393–1396.

51. Dupont E., Craciun L. UV-induced immunosuppressive and anti-inflammatory actions: mechanisms and clinical applications. Immunotherapy. 2009; 1 (2): 205–210.

52. Федулкина В.А., Ватазин А.В., Кильдюшевский А.В., Столяревич Е.С., Кантария Р.О., Зулькарнаев А.Б. Трансляционная клеточная иммунотерапия при ал- лотрансплантации трупной почки у урологических больных. Альманах клинической медицины. 2013; 28: 25–31.

53. Fedulkina V.A., Vatazin A.V., Kil'djushevskij A.V., Stolja- revich E.S., Kantarija R.O., Zul'karnaev A.B. Translati- onal cellular immunotherapy in urological patients after cadaveric kidney allograft. Al'manah klinicheskoj medi- ciny. 2013; 28: 25–31 (in rus).


Review

For citations:


Vatazin A.V., Zul'karnaev A.B., Kil'djushevskij A.V., Fedulkina V.A., Krstic M. SOME OF THE MECHANISMS OF EXTRACORPOREAL PHOTOCHEMOTHERAPY IN SOLID ORGAN TRANSPLANTATION. Russian Journal of Transplantology and Artificial Organs. 2014;16(1):76-84. (In Russ.) https://doi.org/10.15825/1995-1191-2014-1-76-84

Views: 1451


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1995-1191 (Print)