НЕКОТОРЫЕ МЕХАНИЗМЫ ДЕЙСТВИЯ ЭКСТРАКОРПОРАЛЬНОЙ ФОТОХИМИОТЕРАПИИ ПРИ ТРАНСПЛАНТАЦИИ СОЛИДНЫХ ОРГАНОВ
Аннотация
Снижение риска развития отторжения почечного трансплантата – перспективное направление современ- ной медицинской науки. Одним из перспективных методов снижения активности иммунологического конфликта между реципиентом и донорским органом и достижения частичной иммунологической толе- рантности является фотохимиотерапия. Этот метод широко применяется за рубежом при трансплантации сердца и легких. Отечественный опыт применения этого метода у реципиентов почечного транспланта- та крайне мал. В настоящем обзоре литературы представлено современное представление о механизме действия этого метода.
Об авторах
А. В. Ватазин
УЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского», Москва, Российская Федерация
А. Б. Зулькарнаев
ГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского», Москва, Российская Федерация
А. В. Кильдюшевский
ГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского», Москва, Российская Федерация
В. А. Федулкина
ГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского», Москва, Российская Федерация
М. Крстич
ГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского», Москва, Российская Федерация
Список литературы
1. СПИСОК ЛИТЕРАТУРЫ / REFERENCES
2. MCKenna K.E., Whittaker S., Rhodes L.E., Tailor P., Lloyd J., Ibbson S., Russel-Jones R. Evidence – baced practice of photopheresis 1987 – 2001: a report of a workshop of the British Photodermatology group and the U.K. skin lymphoma group. Br. J. Dermatol. 2006; 154: 7–20.
3. Pierelli L., Perseghin P., Marchetti M., Messina C., Pe- rotti C., Mazzoni A., Bacigalupo A., Locatelli F., Carli- er P., Bosi A. Società Italiana di Emaferesi and Manipo- lazione Cellulare (SIdEM) and Gruppo Italiano Trapianto Midollo Osseo (GITMO). Extracorporeal photopheresis for the treatment of acute and chronic graft-versus-host disease in adults and children: best practice recommen- dations from an Italian Society of Hemapheresis and Cell Manipulation (SIdEM) and Italian Group for Bone Mar- row Transplantation (GITMO) consensus process. Trans- fusion. 2013; 53 (10): 2340–2352.
4. Jaksch P., Scheed A., Keplinger M., Ernst M.B., Dani T., Just U., Nahavandi H., Klepetko W., Knobler R. A pro-
5. spective interventional study on the use of extracorpo- realphotopheresis in patients with bronchiolitis obliter- ans syndrome after lungtransplantation. J. Heart Lung Transplant. 2012; 31 (9): 950–957.
6. Lucid C.E., Savani B.N., Engelhardt B.G., Shah P., Clif- ton C., Greenhut S.L., Vaughan L.A., Kassim A., Schuen- ing F., Jagasia M. Extracorporeal photopheresis in pa- tients with refractory bronchiolitis obliterans developing after allo-SCT. Bone Marrow Transplant. 2011; 46 (3): 426–429.
7. Dall'Amico R., Montini G., Murer L., Andreetta B., Zac- chello G., Gambino A., Feltrin G., Caforio A., Tursi V., Livi U. Extracorporeal photochemotherapy after cardiac transplantation: a new therapeutic approach to allograft rejection. Int. J. Artif. Organs. 2000; 23 (1): 49–54.
8. Marques M.B., Schwartz J. Update on extracorporeal photopheresis in heart and lung transplantation. J. Clin. Apher. 2011; 26 (3): 146–151.
9. Urbani L., Mazzoni A., Colombatto P., Biancofiore G., Bindi L., Tascini C., Menichetti F., Brunetto M., Sca- tena F., Filipponi F. Potential applications of extracor- poreal photopheresis in liver transplantation. Transplant. Proc. 2008; 40 (4): 1175–1178.
10. Urbani L., Mazzoni A., Bianco I., Grazzini T., De Simo- ne P., Catalano G., Montin U., Petruccelli S., Morelli L., Campani D., Pollina L., Biancofiore G., Bindi L., Tas- cini C., Menichetti F., Scatena F., Filipponi F. The role of immunomodulation in ABO-incompatible adult liver transplant recipients. J. Clin. Apher. 2008; 23 (2): 55–62.
11. Kusztal M., Kościelska-Kasprzak K., Gdowska W., Zabińska M., Myszka M., Kłak R., Krajewska M., Boratyńska M., Szyber P., Chudoba P., Patrzałek D., Klinger M. Extracorporeal photopheresis as an antirejec- tion prophylaxis in kidney transplant recipients: prelimi- nary results. Transplant. Proc. 2011; 43 (8): 2938–2940.
12. Scarisbrick J. Extracorporeal photopheresis: what is it and when should it be used? Clin. Exp. Dermatol. 2009; 34 (7): 757–760.
13. Genberg H., Kumlien G., Shanwell A., Tydén G. Refrac- tory acute renal allograft rejection successfully treated with photopheresis. Transplant. Proc. 2005; 37 (8): 3288–3289.
14. Jardine M.J., Bhandari S., Wyburn K.R., Misra A.K., McKenzie P.R., Eris J.M. Photopheresis therapy for problematic renal allograft rejection. J. Clin. Apher. 2009; 24 (4): 161–169.
15. Lai Q., Pretagostini R., Gozzer M., Cinti P., Meo D., Vita F., Bafti M.S., Poli L., Novelli G., Rossi M., Gire- lli G., Berloco P.B. Multimodal treatment for acute an- tibody-mediated renal transplant rejection: successful rescue therapy with combined plasmapheresis, photo- pheresis and intravenous immunoglobulin. G. Ital. Ne- frol. 2012; 29 Suppl 54: S31–35.
16. Benden C., Speich R., Hofbauer G.F., Irani S., Eich- Wanger C., Russi E.W., Weder W., Boehler A. Extracor- poreal photopheresis after lung transplantation: a 10- year single-center experience. Transplantation. 2008; 86 (11): 1625–1627.
17. Morrell M.R., Despotis G.J., Lublin D.M., Patter- son G.A., Trulock E.P., Hachem R.R. The efficacy of photopheresis for bronchiolitis obliterans syndrome after lung transplantation. J. Heart Lung Transplant. 2010; 29 (4): 424–431.
18. Salerno C.T., Park S.J., Kreykes N.S., Kulick D.M., Sa- vik K., Hertz M.I., Bolman R.M. 3rd. Adjuvant treatment of refractory lung transplant rejection with extracorpo- real photopheresis. J. Thorac. Cardiovasc. Surg. 1999; 117 (6): 1063–1069.
19. Villanueva J., Bhorade S.M., Robinson J.A., Husain A.N., Garrity E.R. Jr. Extracorporeal photopheresis for the treatment of lung allograft rejection. Ann. Transplant. 2000; 5 (3): 44–47.
20. Giunti G., Schürfeld K., Maccherini M., Tanganelli P., Rubegni P., Alfani D., D'Ascenzo G., Diciolla F., Bernaz- zali S., Fimiani M., Toscano M., Sani G. Photopheresis for recurrent acute rejection in cardiac transplantation. Transplant. Proc. 1999; 31 (1–2): 128–129.
21. Maccherini M., Diciolla F., Laghi Pasini F., Lisi G., Tan- ganelli P., D'Ascenzo G., Mondillo S., Carone E., Oric- chio L., Baraldi C., Capecchi P.L., Lazzerini P.E., Tosca- no T., Barretta A., Giunti G., Schuerfeld K., Fimiani M., Papalia U. Photopheresis immunomodulation after heart transplantation. Transplant. Proc. 2001; 33 (1–2): 1591– 1594.
22. Barr M.L., Meiser B.M., Eisen H.J., Roberts R.F., Livi U., Dall'Amico R., Dorent R., Rogers J.G., Radovancević B., Taylor D.O., Jeevanandam V., Marboe C.C. Photophere- sis for the prevention of rejection in cardiac transplan- tation. Photopheresis Transplantation Study Group. N. Engl. J. Med. 1998; 339 (24): 1744–51.
23. Kirklin J.K., Brown R.N., Huang S.T., Naftel D.C., Hub- bard S.M., Rayburn B.K., McGiffi n D.C., Bourge R.B., Benza R.L., Tallaj J.A., Pinderski L.J., Pamboukian S.V., George J.F., Marques M. Rejection with hemodynamic compromise: objective evidence for efficacy of photo- pheresis. J. Heart Lung Transplant. 2006; 25 (3): 283– 288.
24. Holtick U., Wang X.N., Marshall S.R., Scheid C., von Bergwelt-Baildon M., Dickinson A.M. In vitro PUVA treatment preferentially induces apoptosis in alloacti- vated T cells. Transplantation. 2012; 94 (5): e31–34.
25. Hannani D., Gabert F., Laurin D., Sall M., Molens J.P., Hequet O., Chaperot L., Plumas J. Photochemotherapy induces the apoptosis of monocytes without impairing their function. Transplantation. 2010; 89 (5): 492–499.
26. Hannani D., Merlin E., Gabert F., Laurin D., De- méocq F., Chaperot L., Kanold J., Plumas J. Photoche- motherapy induces a faster apoptosis of alloreactive ac- tivated T cells than of nonalloreactive resting T cells in graft versus host disease. Transplantation. 2010; 90 (11): 1232–1238.
27. Baron E.D., Heeger P.S., Hricik D.E., Schulak J.A., Tary- Lehmann M., Stevens S.R. Immunomodulatory effect of extracorporeal photopheresis after successful treatment of resistant renal allograft rejection. Photodermatol. Photoimmunol. Photomed. 2001; 17 (2): 79–82.
28. Fimiani M., Di Renzo M., Rubegni P. Mechanism of ac- tion of extracorporeal photochemotherapy in chronic graft-versus-host disease. Br. J. Dermatol. 2004; 150 (6): 1055–1060.
29. Setterblad N., Garban F., Weigl R., Assier E., Drillat P., Charron D., Dickinson A., Greinix H., Mooney N. Extra- corporeal photophoresis increases sensitivity of monocytes from patients with graft-versus-host disease to HLA-DR- mediated cell death. Transfusion. 2008; 48 (1): 169–177.
30. Bains S.K., Mone A., Yun Tso J., Lucas D., Byrd J.C., Weiner G.J., Green J.M. Mitochondria control of cell death induced by anti-HLA-DR antibodies. Leukemia. 2003; 17 (7): 1357–1365.
31. Bladon J., Taylor P. Extracorporeal photopheresis re- duces the number of mononuclear cells that produce pro- inflammatory cytokines, when tested ex-vivo. J. Clin. Apher. 2002; 17 (4): 177–182.
32. Bladon J., Taylor P.C. Lymphocytes treated by extracor- poreal photopheresis can down-regulate cytokine pro- duction in untreated monocytes. Photodermatol. Photo- immunol. Photomed. 2005; 21 (6): 293–302.
33. Ghafari A., Makhdoomi K., Ahmadpour P., Afshari A.T., Lak S.S., Fakhri L. Serum T-lymphocyte cytokines can- not predict early acute rejection in renal transplantation. Transplant. Proc. 2007; 39 (4): 958–961.
34. Holtick U., Wang X.N., Marshall S.R., Scheid C., von Bergwelt-Baildon M., Dickinson A.M. Immature DC isolated after co-culture with PUVA-treated peripheral blood mononuclear cells downregulate graft-versus-host reactions in the human skin explant model. Curr. Stem Cell Res. Ther. 2013; 8 (4): 324–332.
35. del Rio M.L., Buhler L., Gibbons C., Tian J., Rodriguez- Barbosa J.I. PD-1/PD-L1, PD-1/PD-L2, and other co-in- hibitory signaling pathways in transplantation. Transpl. Int. 2008; 21 (11): 1015–1028.
36. Wolnicka-Glubisz A., Fraczek J., Skrzeczynska-Monc- znik J., Friedlein G., Mikolajczyk T., Sarna T., Pryjma J. Effect of UVA and 8-methoxypsoralen, 4, 6, 4'-trimethy- langelicin or chlorpromazine on apoptosis of lympho- cytes and their recognition by monocytes. J. Physiol. Pharmacol. 2010; 61 (1): 107–114.
37. Di Renzo M., Rubegni P., Pasqui A.L., Pompella G., De Aloe G., Sbano P., Cuccia A., Castagnini C., Auteri A., Laghi Pasini F., Fimiani M. Extracorporeal photophere- sis affects interleukin (IL)-10 and IL-12 production by monocytes in patients with chronic graft-versus-host di- sease. Br. J. Dermatol. 2005; 153 (1): 59–65.
38. Peritt D. Potential mechanisms of photopheresis in he- matopoietic stem cell transplantation. Biol. Blood Mar- row Transplant. 2006; 12 (1 Suppl 2): 7–12.
39. Di Renzo M., Sbano P., De Aloe G., Pasqui A.L., Ru- begni P., Ghezzi A., Auteri A., Fimiani M. Extracorporeal photopheresis affects co-stimulatory molecule expres- sion and interleukin-10 production bydendritic cells in graft-versus-host disease patients. Clin. Exp. Immunol. 2008; 151 (3): 407–413.
40. Dhodapkar M.V., Steinman R.M., Krasovsky J., Munz C., Bhardwaj N. Antigen-specific inhibition of effector T cell function in humans after injection of immature den- dritic cells. J. Exp. Med. 2001; 193 (2): 233–238.
41. Dhodapkar M.V., Steinman R.M. Antigen-bearing imma- ture dendritic cells induce peptide-specific CD8(+) regu- latory T cells in vivo in humans. Blood. 2002; 100 (1): 174–177.
42. 40. Spisek R., Gasova Z., Bartunkova J. Maturation state of dendritic cells during the extracorporeal photopheresis and its relevance for the treatment of chronic graft-ver- sus-host disease. Transfusion. 2006; 46 (1): 55–65.
43. Failli A., Legitimo A., Mazzoni A., Urbani L., Scatena F., Mosca F., Consolini R. The combination of immunosup- pressive drugs with 8-methoxypsoralen and ultraviolet a light modulates the myeloid-derived dendritic cell function. Int. J. Immunopathol. Pharmacol. 2011; 24 (1): 89–99.
44. Tan J.K., O'Neill H.C. Maturation requirements for den- dritic cells in T cell stimulation leading to tolerance ver- sus immunity. J. Leukoc. Biol. 2005; 78 (2): 319–324.
45. Usharauli D. Dendritic cells and the immunity/tolerance decision. Med. Hypotheses. 2005; 64 (1): 112–113.
46. Meloni F., Cascina A., Miserere S., Perotti C., Vitulo P., Fietta A.M. Peripheral CD4(+)CD25(+) TREG cell counts and the response to extracorporeal photopheresis in lung transplant recipients. Transplant. Proc. 2007; 39 (1): 213–217.
47. George J.F., Gooden C.W., Guo L., Kirklin J.K. Role for CD4(+)CD25(+) T cells in inhibition of graft rejection by extracorporeal photopheresis. J. Heart Lung Trans- plant. 2008; 27 (6): 616–622.
48. Rubegni P., Sbano P., Cevenini G., Perari M.G., Ma- rotta G., Risulo M., Carcagnì M.R., D' Ascenzo G., De
49. Aloe G., Fimiani M. CD4+CD25+ lymphocyte subsets in chronic graft versus host disease patients undergoing ex- tracorporeal photochemotherapy. Int. J. Immunopathol. Pharmacol. 2007; 20 (4): 801–807.
50. Lamioni A., Carsetti R., Legato A., Landolfo A., Isac- chi G., Emma F., Bottazzo G.F., Dello Strologo L. In- duction of regulatory T cells after prophylactic treatment with photopheresis in renal transplant recipients. Trans- plantation. 2007; 83 (10): 1393–1396.
51. Dupont E., Craciun L. UV-induced immunosuppressive and anti-inflammatory actions: mechanisms and clinical applications. Immunotherapy. 2009; 1 (2): 205–210.
52. Федулкина В.А., Ватазин А.В., Кильдюшевский А.В., Столяревич Е.С., Кантария Р.О., Зулькарнаев А.Б. Трансляционная клеточная иммунотерапия при ал- лотрансплантации трупной почки у урологических больных. Альманах клинической медицины. 2013; 28: 25–31.
53. Fedulkina V.A., Vatazin A.V., Kil'djushevskij A.V., Stolja- revich E.S., Kantarija R.O., Zul'karnaev A.B. Translati- onal cellular immunotherapy in urological patients after cadaveric kidney allograft. Al'manah klinicheskoj medi- ciny. 2013; 28: 25–31 (in rus).
Рецензия
Для цитирования:
Ватазин А.В., Зулькарнаев А.Б., Кильдюшевский А.В., Федулкина В.А., Крстич М. НЕКОТОРЫЕ МЕХАНИЗМЫ ДЕЙСТВИЯ ЭКСТРАКОРПОРАЛЬНОЙ ФОТОХИМИОТЕРАПИИ ПРИ ТРАНСПЛАНТАЦИИ СОЛИДНЫХ ОРГАНОВ. Вестник трансплантологии и искусственных органов. 2014;16(1):76-84. https://doi.org/10.15825/1995-1191-2014-1-76-84
For citation:
Vatazin A.V., Zul'karnaev A.B., Kil'djushevskij A.V., Fedulkina V.A., Krstic M. SOME OF THE MECHANISMS OF EXTRACORPOREAL PHOTOCHEMOTHERAPY IN SOLID ORGAN TRANSPLANTATION. Russian Journal of Transplantology and Artificial Organs. 2014;16(1):76-84. (In Russ.) https://doi.org/10.15825/1995-1191-2014-1-76-84
Просмотров: 1209
Послать статью по эл. почте 