ENDOTOXIN ADSORPTION IN TREATMENT OF SELECTIVE SEPTIC COMPLICATIONS IN PATIENTS WITH UROLOGICAL DISEASES AFTER RENAL TRANSPLANTATION
https://doi.org/10.15825/1995-1191-2014-1-21-28
Abstract
Aim. Treatment of urosepsis in patients after renal transplantation is very difficult. Currently selective endotoxin adsorption is a perspective method of treatment. Works devoted to the study of the effectiveness of this method in patients with renal transplant are extremely rare.
Materials and methods. 94 recipients were included in study: 54 in prospective main group and 40 – in retrospective comparison group. For each patient of the main group we performed 2 sessions of selective endotoxin adsorption. Patients of comparison group were not trea- ted with sorption of endotoxin. We investigated the dynamics of APACHE II score, the concentration of IL-6, IL-8, TNF-alpha, procalcitonin and endotoxin.
Results. As a result of endotoxin adsorption there was noted more pronounced decrease in the APACHE II score in patients of the main group, than in the comparison group. There was a decrease in activity of the systemic inflammatory response, and that was reflected in the decrease in the concentration of proinflammatory cytokines and procalcitonin in patients of the main group. Application of endotoxin adsorption resulted in a significant increase in survival in patients of the main group.
Conclusion. Sorption of endotoxin is very effective and safe procedure that affects the pathogenesis of sepsis. Application of this procedure can significantly improve the condition of patients and survival.
About the Authors
M. Krstic
Government Budget Health Institution of Moscow region «M.F. Vladimirsky Moscow Regional Research
Clinical Institute», Moscow, Russian Federation
A. B. Zul ́karnaev
Government Budget Health Institution of Moscow region «M.F. Vladimirsky Moscow Regional Research
Clinical Institute», Moscow, Russian Federation
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Review
For citations:
Krstic M., Zul ́karnaev A.B. ENDOTOXIN ADSORPTION IN TREATMENT OF SELECTIVE SEPTIC COMPLICATIONS IN PATIENTS WITH UROLOGICAL DISEASES AFTER RENAL TRANSPLANTATION. Russian Journal of Transplantology and Artificial Organs. 2014;16(1):21-28. (In Russ.) https://doi.org/10.15825/1995-1191-2014-1-21-28
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