THE MATHEMATICAL MODELING ESTIMATION OF THE AORTIC VALVE STATE DURING MECHANICAL CIRCULATORY SUPPORT
https://doi.org/10.15825/1995-1191-2014-4-62-67
Abstract
Aim. This work is to research the aortic valve functioning during left ventricle bypass with non-pulsatile pump.
Materials and methods. The main part of the research is author’s algorithm to estimate aortic valve state (open/closed). The research includes mathematical modeling, mock loop experiments and animal experiments.
Results. The author develops the algorithm of rotary blood pump fl owrate processing to estimate (with reliability of more than 90%) the state of aortic valve during heart mechanical support.
Conclusion. The proposed algorithm of estimating the aortic valve state allows identifying abnormal mode of cardiac support that can cause thrombosis and aortic valve commissural fusion. This algorithm can be incorporated into nonpulsatile LVAD.
About the Authors
I. B. Bykov
Laboratory of Biotechnical Systems, V.I.Shumakov Federal Research Center of Transplantology
and Artifi cial Organs, Ministry of Health of the Russian Federation, Moscow, Russian Federation
Russian Federation
Russian Federation
G. P. Itkin
Laboratory of Biotechnical Systems, V.I.Shumakov Federal Research Center of Transplantology
and Artifi cial Organs, Ministry of Health of the Russian Federation, Moscow, Russian Federation
Russian Federation
Russian Federation
References
1. World health statistics. World Health Organisation. 2012.
2. Westaby S. Destination therapy: tim e for real progress. Nat. Clin. Pract. Cardiovasc. Med. 2008; 5: 477–483. Slaughter MS, Rogers JG, Milano CA, Russel SD, Conte JV, Feldman D et al. Advanced heart failure treated with continuous-fl ow left ventricular assist device. N. Engl. J. Med. 2009; 361: 2241–2251.
3. Kirklin JK, Naftel DC, Kormos RL, Stevenson LW, Pagani FD, Miller MA et al. The Fourth INTERMACS Annual Report: 4,000 implants and counting. J Heart and Lung Transplantation. 2012; 31 (2): 117–126.
4. McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Boehm M, Dickstein K et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur. J. Heart. Fail. 2012; 14: 803–869.
5. Готье СВ, Иткин ГП, Шемакин СЮ, Саитгареев РШ, Попцов ВН, Захаревич ВМ и др. Первый опыт клинического применения отечественного аппарата вспомогательного кровообращения на базе имплантируемого осевого насоса для двухэтапной трансплантации сердца. Вестник трансплантологии и искусственных органов. 2013; 15 (3): 92–101. Gautier SV, Itkin GP, Shemakin SJu, Saitgareev RSh, Popcov VN, Zaharevich VM. The fi rst experience in clinical application of domestic circulatory support device on basis of implantable axial pump for two stage heart transplantation. Vestnik transplantologii i iskusstvennyh organov. 2013; 15 (3): 92–101. [In Russ]
6. Быков ИВ, Иткин ГП. Принципы построения математической модели для исследования взаимодействия насосов непрерывного потока и сердечно-сосудистой системы. Вестник трансплантологии и искусственных органов. 2013; 15 (3): 59–65. Bykov IV, Itkin GP. Principles of development mathematical model for researching of nonpulsatile fl ow pump and cardiac system. Vestnik transplantologii i iskusstvennyh organov. 2013; 15 (3): 59–65. [In Russ]
7. Robinson D. Quantitative analysis of the control of cardiac output in the isolated left ventricle. Circulation Research. 1965; 17: 207–221.
8. Иткин ГП, Шемакин СЮ, Шохина ЕГ, Бурцев ВИ, Аврамов ПВ, Волкова ЕА и др. Результаты экспериментальных исследований на телятах первого отечественного имплантируемого осевого насоса. Вестник трансплантологии и искусственных органов. 2013; 15 (3): 49–58. Itkin GP, Shemakin SJu, Shohina EG, Burcev VI, Avramov PV, Volkova EA et al. The fi rst domestic implantable axial fl ow pump: results of experimental studies in calves. Vestnik transplan tologii i iskusstvennyh organov. 2013; 15 (3): 49–58. [In Russ]
9. Valsecchi S, Perego GB, Censi F, Schreuder JJ. Estimation of Cardiac Output from Left Ventricular Pressure by a Modifi ed Modelfl ow Method. Computers in Cardiology. 2006; 33: 873–876.
10. Вашуркин ДВ. Разработка методологии проектирования и создания осевого насоса имплантируемой системы вспомогательного кровообращения [Диссертация]. М., 2007: 159. Vashurkin DV. Razrabotka metodologii proektirovanija i sozdanija osevogo nasosa implantiruemoj sistemy vspomogatel'nogo krovoobrashhenija [Dissertation]. Moscow, 2007: 159.
Review
For citations:
Bykov I.B., Itkin G.P. THE MATHEMATICAL MODELING ESTIMATION OF THE AORTIC VALVE STATE DURING MECHANICAL CIRCULATORY SUPPORT. Russian Journal of Transplantology and Artificial Organs. 2014;16(4):62-67. (In Russ.) https://doi.org/10.15825/1995-1191-2014-4-62-67
Views:
1417
Email this article 