SURVIVAL OF LIVER CELLS, IMMOBILIZED ON 3D-MATRIXES, IN LIVER FAILURE MODEL
https://doi.org/10.15825/1995-1191-2011-3-59-66
Abstract
It was examined a new method for correction of hepatic failure by transplantation of liver support biounit (liver cells, immobilized on biocompatible and biodegradable 3D-matrixes ElastoPOB®) into small intestine mesentery. It was determined that after modeling of acute hepatic failure on dogs by 65–70% liver resection) and transplantation liver support biounit the restoration of disturbed biochemical indecies (such as total protein, lactate, cytolytic ensymes-ALT, AST, ALP, LDH, fibrinogen, protrombine index and others) took place more rapidly on 9–14th day instead of 18th day in control.
It was made a preposition about efficiency of the suggested method for correction both acute hepatic failure because even 90 days after transplantation of liver support biounit alive hepatocytes and neogenic plethoric vessels, growing through matrix were revealed.
About the Authors
M. Y. Shagidulin
Academician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
N. A. Onishchenko
Academician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
M. E. Krasheninnikov
Academician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
I. M. Iljinsky
Academician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
N. P. Mogeiko
Academician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
N. P. Shmerko
Academician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
A. A. Andriyanova
Academician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
P. V. Avramov
Academician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
E. A. Nemets
Academician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
V. I. Sevastjanov
Academician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
S. V. Gautier
Academician V.I. Schumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
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For citations:
Shagidulin M.Y., Onishchenko N.A., Krasheninnikov M.E., Iljinsky I.M., Mogeiko N.P., Shmerko N.P., Andriyanova A.A., Avramov P.V., Nemets E.A., Sevastjanov V.I., Gautier S.V. SURVIVAL OF LIVER CELLS, IMMOBILIZED ON 3D-MATRIXES, IN LIVER FAILURE MODEL. Russian Journal of Transplantology and Artificial Organs. 2011;13(3):59-66. (In Russ.) https://doi.org/10.15825/1995-1191-2011-3-59-66
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