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DYNAMICS OF CD34/CD45 POSITIVE CELLS CONCENTRATION IN PERIPHERAL BLOOD OF PATIENTS AFTER ORTHOTOPIC LIVER TRANSPLANTATION AND PARTIAL LIVER RESECTION

https://doi.org/10.15825/1995-1191-2011-3-8-14

Abstract

Number of CD34/CD45+ cells were determined in blood of pediatric recipients and adult living-related liver do- nors. It has been investigated 15 pairs of recipients (aged from 4 to 60 months) and donors (29 ± 5 years). All the children had liver cirrhosis caused by congenital and inherited diseases of hepatobiliary system. Concentration of CD34/CD45+ cells in venous blood of recipients was higher than in donors. In recipients level of CD34/CD45+ cells did not correlate with sex, age, weight and height but did correlate with some biochemical parameters related to liver function. After liver transplantation number of CD34/CD45+ cells did not change in peripheral blood of recipients. In donors partial liver resection did not cause statistically significant changes in number or concentration of CD34/CD45+ cells in blood. Presented data suggests that neither liver transplantation nor liver resection has remarkable influence on number of CD34/CD45 + cells in peripheral blood. 

About the Authors

O. P. Shevchenko
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation


O. M. Tsirulnikova
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation


R. M. Kurabekova
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation


S. A. Lugovskaya
Russian Medical Academy of Postgraduate Education, Moscow
Russian Federation


E. V. Naumova
Russian Medical Academy of Postgraduate Education, Moscow
Russian Federation


N. Sh. Muratova
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation


I. E. Tsirulnikova
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation


S. V. Gautier
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation


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For citations:


Shevchenko O.P., Tsirulnikova O.M., Kurabekova R.M., Lugovskaya S.A., Naumova E.V., Muratova N.Sh., Tsirulnikova I.E., Gautier S.V. DYNAMICS OF CD34/CD45 POSITIVE CELLS CONCENTRATION IN PERIPHERAL BLOOD OF PATIENTS AFTER ORTHOTOPIC LIVER TRANSPLANTATION AND PARTIAL LIVER RESECTION. Russian Journal of Transplantology and Artificial Organs. 2011;13(3):8-14. (In Russ.) https://doi.org/10.15825/1995-1191-2011-3-8-14

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ISSN 1995-1191 (Print)