MOBILIZATION OF STEM CELLS AFTER LIVER TRANSPLANTATION AND RESECTION
https://doi.org/10.15825/1995-1191-2010-4-86-92
Abstract
The review article analyses the published literature for mobilization of CD34/CD45 positive bone marrow cells into peripheral blood after liver injury. Recent investigations of mechanism of bone marrow stem cells mobiliza- tion into peripheral blood, role of the stem cells in recovery of injured liver and clinical studies of hematopoietic stem cells mobilization after liver transplantation and resection are discussed in the review. Recently some stu- dies have demonstrated that bone marrow stem cells can participate in recovery of liver tissue and functions after its injury. Mobilization of bone marrow stem cells into peripheral blood after liver injury is one of the possible evidence of such participation. The mobilization of bone marrow stem cells was shown in experimental models and in clinical investigations. However the issue is still controversial as there are publications which failed to find mobilization of bone marrow stem cells into peripheral blood after liver transplantation or resection in pa- tients. In this review we investigate and summarize recent research of the topic.
About the Authors
R. M. Kurabekova
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
O. M. Tsirulnikova
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
O. P. Shevchenko
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
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Review
For citations:
Kurabekova R.M., Tsirulnikova O.M., Shevchenko O.P. MOBILIZATION OF STEM CELLS AFTER LIVER TRANSPLANTATION AND RESECTION. Russian Journal of Transplantology and Artificial Organs. 2010;12(4):86-92. (In Russ.) https://doi.org/10.15825/1995-1191-2010-4-86-92
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