TRANSPLANTATION OF HEPATOCYTES AS THE METHOD OF TREATMENT OF LIVER FAILURE: EXPERIMENTAL AND CLINICAL EXPERIENCE
https://doi.org/10.15825/1995-1191-2010-4-53-60
Abstract
For correction and treatment of liver failure before liver transplantation were proposed severe methods such as: extracorporal devices, transplantation of hepatocytes and implanted tissue-engineering units. The function of healthy hepatocytes presumes to stabilize the state of patients with chronic liver diseases and to wait a donor organ transplantation. In this review the results of experimental and clinical therapy of liver diseases by method of hepatocyte transplantation were summarized.
About the Authors
M. Y. Shagidulin
Academician V.I. Shumakow Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
N. A. Onishchenko
Academician V.I. Shumakow Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
M. E. Krasheninnikov
Academician V.I. Shumakow Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
References
1. Дифференциальная диагностика и лечение внутрен- них болезней: Руководство для врачей. Т. 2. Болезни органов пищеварения / Под ред. А.И. Хазанова. М., 2003. С. 281–306.
2. Lui W.Y. et al. Evaluation of a simplified staging system for prognosis of hepatocellular carcinoma // J. Formos Med. Assoc. 2009. Vol. 98. No 4. P. 248–253.
3. Шагидулин М.Ю., Онищенко Н.А., Шумаков В.И. Со- временные методы лечения печеночной недостаточ-
4. ности в клинике перед трансплантацией печени // Вестник трансплантологии и искусственных орга- нов. 2006. No 3. С. 56–62.
5. Muiesan P., Girlanda R., Jassem W. et al. Single-center experience with liver transplantation from controlled non-heart-beating donors: a viable source of grafts // Ann. Surg. 2005. Vol. 242. P. 732–738.
6. United Network for Organ Sharing. http://www. unos. org.
7. Moysyk Y.G., Sharshatkin A.V., Iljanov M.I. et al. Impro- ved results of liver transplantation from extended criteria donors by shortening of the preservation, warm ische- mic and operative time // Transplant international. 2007. Vol. 20. Supl. 2. P. 275.
8. www.eurotransplant.nl/files/statistics.
9. Pietrosi G., Vizzini G.B., Gruttadauria S., Gridelli B. Clinical applications of hepatocyte transplantation // World
10. J. Gastroenterol. 2009. Vol. 15. No 17. Р. 2074–2077.
11. Strom S.C., Fisher R.A., Thompson M.T. et al. Hepato- cyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure // Transplantation. 1997. Vol. 63. P. 559–569.
12. Smets F., Najimi M., Sokal E.M. Cell transplantation in the treatment of liver diseases // Pediatr. Transplant.
13. Vol. 12. P. 6–13.
14. Palmes D., Qayumi A.K., Spiegel H.U. Liver bridging techniques in the treatment of acute liver failure // J. Invest. Surg. 2000. Vol. 3. P. 299–311.
15. Ohashi K., Park F., Kay M.A. Hepatocyte transaplantation: clinical and experimental application // J. Mol. Med. 2001. Vol. 79. P. 617–630.
16. Gupta S., Chowdhury R.J. Therapeutic potential of hepatocyte transplantation // Cell & Developmental Biology.
17. Vol. 13. P. 439–446.
18. Fox I.J., Chowdhury J.R. Hepatocyte transplantation // Am. J. of Transplantation. 2004. Vol. 4. P. 7–13.
19. Fox I.J., Roy-Chowdhury J. Hepatocyte transplantation // J. Hepatol. 2004. Vol. 40. P. 878–886.
20. Horslen S.P., Fox I.J. Hepatocyte transplantation // Transplantation. 2004. Vol. 77. P. 1481–1486.
21. Fisher R.A., Strom S.C. Human hepatocyte transplantati- on: Worldwide results // Transplantation. 2006. Vol. 82.
22. P. 441–449.
23. Fox I.J., Chowdhury J.R. Hepatocyte transplantation // Am. J. Transplant. 2004. Vol. 4. P. 7–13.
24. Malhi H., Gupta S. Hepatocyte transplantation: new horizons and challenges // J. Hepatobiliary Pancreat. Surg.
25. Vol. 8. P. 40–45.
26. Kobayashi N., Fujiwara T., Westerman K.A. et al. Prevention of acute liver failure in rats with reversibly im- mortalized human hepatocytes // Science. 2000. Vol. 287. P. 1258–1262.
27. Berry M.N., Friend D.S. High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study // J. Cell Biol. 1969. Vol. 43. P. 506–520.
28. Pareja E., Martínez A., Cortés M., Bonora A., Moya Á., Sanjuán F., Gómez-Lechón M.J., Miraa J. Hepatic cell transplantation. Technical and methodological aspects // Cir. Esp. 2010. Vol. 87. P. 139–147.
29. Mitry R.R., Hughes R.D., Dhawan A. Progress in human hepatocytes: isolation, culture & cryopreservation // Se- min. Cell Dev. Biol. 2002. Vol. 13. P. 463–467.
30. Lake J. Hepatocyte transplantation // N. Engl. J. Med. 1998. Vol. 338. P. 1463–1465.
31. Baccarani U., Sanna A., Cariani A. et al. Isolation of human hepatocytes from livers rejected for liver trans- plantation on a national basis: results of a 2-year experi- ence // Liver Transpl. 2003. Vol. 9. P. 506–512.
32. Mitry R.R., Dhawan A., Hughes R.D. et al. One liver, three recipients: segment IV from split-liver procedu- res as a source of hepatocytes for cell transplantation // Transplantation. 2004. Vol. 77. P. 1614–1616.
33. Allen K.J., Soriano H.E. Liver cell transplantation: The road to clinical application // J. Lab. Clin. Med. 2001. Vol. 138. P. 298–312.
34. Sandhu J.S., Petkov P.M., Dabeva M.D., Shafritz D.A. Stem cell properties and repopulation of the rat liver by fetal liver epithelial progenitor cells // Am. J. Pathol. 2001. Vol. 159. P. 1323–1334.
35. Raper S.E., Grossman M., Rader D.J. et al. Safety and Feasibility of Liver-Directed ex vivo Gene Therapy for Homozygous Familial Hypercholesterolemia // Ann. Surg. 1997. Vol. 223. P. 116–126.
36. Eiseman B. Treatment of liver failure // Read AE, ed. Colston Papers No 19 The Liver. London: Butterworths, 1967. 279 р.
37. Guha C., Parashar B., Deb N.J. et al. Normal hepatocy- tes correct serum bilirubin after repopulation of Gunn rat liver subjected to irradiation / partial resection // Hepato- logy. 2002. Vol. 36. P. 354–362.
38. Kobayashi N., Ito M., Nakamura J. et al. Hepatocyte transplantation in rats with decompensated liver cirrho- sis // Hepatology. 2000. Vol. 31. P. 851–857.
39. Nussler A., Konig S., Ott M. et al. Present status and perspectives of cell-based therapies for liver diseases // J. Hepatol. 2006. Vol. 45. P. 144–159.
40. Hasirci V., Berthiaume F., Bondre S.P. et al. Expressi- on of liver-specific functions by rat hepatocytes seeded in treated poly(lactic-co-glycolic) acid biodegradable foams // Tissue Eng. 2001. Vol. 7. P. 385–394.
41. Ranucci C.S., Kumar A., Batra S.P., Moghe P.V. Control of hepatocyte function on collagen foams: Sizing matrix pores toward selective induction of 2-D and 3-D cellular morphogenesis // Biomaterials. 2000. Vol. 21. P. 783– 793.
42. Shagidulin M.U., Onishchenko N.A., Krasheninni- kov M.E. et al. Working-out of intracorporated bioartifi- cial liver support unit // Journal of artificial organs. 2008. Vol. 31. No 7. P. 656.
43. Shagidulin M.U., Krasheninnikov M.E., Ilinsky I.M. et al. Matrix ElastoPOB®3-D as a basis for immobilisation of tissue-specific and nonspecific cells and prolonged cel- lular-mediated inductive Influences on damaged organ // The International Journal of Artificial Organs. 2009. Vol. 32. No 7. P. 449–450.
44. Shagidulin M.U., Krasheninnikov M.E., Ilinsky I.M. et al. The long-term surviving in vivo autologus hepa- tocytes on 3D matrixes as a path of building of a hyb- rid liver // Organ Donation Congress 10th ISODP & 16th ETCO. 2009. Oct. P. 91.
45. Uyama S., Kaufmann P.M., Kneser U. et al. Hepatocyte transplantation using biodegradable matrices in ascor- bic acid-deficient rats: comparison with heterotopically transplanted liver grafts // Transplantation. 2001. Vol. 71. No 10. P. 1–7.
46. Malhi H., Irani A.N., Gagandeep S., Gupta S. Isolation of human progenitor liver epithelial cells with extensive replication capacity and differentiation into mature hepa- tocytes // Journal of Cell Science. 2002. P. 2679–2688.
47. Mitry R.R., Dhawan A., Hughes R.D. et al. Hepatocy- te transplantation for liver-based metabolic disorders // J. Inherit. Metabol. Dis. 2006. Vol. 29 (2–3). P. 431–435.
48. Sokal E.M. Liver transplantation for inborn errors of liver metabolism // J. Inherit. Metab. Dis. 2006. Vol. 29. P. 426–430.
49. Grossman M., Rader D.J., Muller D.W. et al. A pilot stu- dy of ex vivo gene therapy for homozygous familial hy- percholesterolaemia // Nat. Med. 1995. Vol. 1. P. 1148– 1154.
50. Mazaris E.M., Roussos C.T., Papalois V.E. Hepatocyte transplantation: a review of worldwide clinical develop- ments and experiences // Exp. Clin. Transplant. 2005. Vol. 3. P. 306–315.
51. Strom S.C., Chowdhury J.R., Fox I.J. Hepatocyte trans- plantation for the treatment of human disease // Semin. Liver Dis. 1999. Vol. 19. P. 39–48.
52. Fox I.J., Chowdhury J.R., Kaufman S.S. et al. Treat- ment of the Crigler–Najjar syndrome type I with hepa- tocyte transplantation // N. Engl. J. Med. 1998. Vol. 338. P. 1422–1426.
53. Strom S.C., Fisher R.A., Rubinstein W.S. et al. Transplan- tation of human hepatocytes // Transplant. Proc. 1997. Vol. 29. P. 2103–2106.
54. Bilir B.M., Guinette D., Karrer F. et al. Hepatocyte Transplantation in Acute Liver Failure // Liver Trans- plantation. 2000. Vol. 6. P. 32–40.
55. Mito M., Kusano M., Kawaura Y. Hepatocyte transplan- tation in man // Transplant. Proc. 1992. Vol. 24. P. 3052– 3053.
Review
For citations:
Shagidulin M.Y., Onishchenko N.A., Krasheninnikov M.E. TRANSPLANTATION OF HEPATOCYTES AS THE METHOD OF TREATMENT OF LIVER FAILURE: EXPERIMENTAL AND CLINICAL EXPERIENCE. Russian Journal of Transplantology and Artificial Organs. 2010;12(4):53-60. (In Russ.) https://doi.org/10.15825/1995-1191-2010-4-53-60
Views:
804
Email this article 