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The launch of the upper extremity transplantation program: clinical cases and key aspects of organizing work in a new area of clinical transplantology

https://doi.org/10.15825/1995-1191-2026-1-8-16

Abstract

The loss of an arm (or both arms), not only causes severe physical trauma but also leads to long-term psychological consequences and difficulties in occupational, domestic, and social maladjustment, substantially impairing quality of life. This complex problem is not always addressed effectively with modern high-tech bionic prostheses, which, while enabling the performance of many functional tasks, have inherent limitations. In selected cases, allograft transplantation of an upper limb from a deceased donor may be considered. Until recently, this treatment option was unavailable within the Russian healthcare system. This paper presents the key stages in establishing an upper limb transplant program, including its organizational structure, the roles of its individual components, and the outcomes of practical implementation. The efficacy and safety of the treatment method are illustrated through the first two clinical cases. The experience gained and the outcomes of the first clinical cases are intended to demonstrate the practical feasibility of developing a structured, effective upper limb transplant program that can address the growing demand for this type of high-tech medical care.

About the Authors

S. V. Gautier
Shumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov University
Russian Federation

Moscow



A. G. Nazarenko
Pirogov Russian National Research Medical University
Russian Federation

Moscow



I. V. Pashkov
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation

Moscow



I. O. Golubev
Pirogov Russian National Research Medical University
Russian Federation

Moscow



N. V. Grudinin
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation

Moscow



V. K. Bogdanov
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation

Moscow



M. V. Merkulov
Pirogov Russian National Research Medical University
Russian Federation

Moscow



V. D. Kuznetsov
Pirogov Russian National Research Medical University
Russian Federation

Moscow



I. А. Kutepov
Pirogov Russian National Research Medical University
Russian Federation

Moscow



D. O. Oleshkevich
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation

Moscow



O. M. Tsirulnikova
Shumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov University
Russian Federation

Moscow



A. S. Timanovsky
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation

Moscow



A. N. Sharov
Shumakov National Medical Research Center of Transplantology and Artificial Organs; Tver State Medical University
Russian Federation

Moscow

Tver



D. V. Karpov
Regional Clinical Hospital
Russian Federation

Ryazan



P. N. Tveritnev
First Republican Clinical Hospital
Russian Federation

Izhevsk



A. V. Subbotin
First Republican Clinical Hospital
Russian Federation

Izhevsk



A. G. Pavlov
First Republican Clinical Hospital
Russian Federation

Izhevsk



References

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2. Gurunian R, Rampazzo A, Papay F, Gharb BB, editors. Reconstructive transplantation. Springer International Publishing; 2023 Feb 23.

3. Lanzetta M, Dubernard JM, Petruzzo P, editors. Hand transplantation. Milan: Springer; 2007.

4. Reece E, Ackah R. Hand transplantation: the benefits, risks, outcomes, and future. Texas Heart Institute Journal. 2019 Feb 1;46(1):63-4.

5. Schuind F, Abramowicz D, Schneeberger S. Hand transplantation: the state-of-the-art. Journal of Hand Surgery (European Volume). 2007 Feb;32(1):2-17.


Review

For citations:


Gautier S.V., Nazarenko A.G., Pashkov I.V., Golubev I.O., Grudinin N.V., Bogdanov V.K., Merkulov M.V., Kuznetsov V.D., Kutepov I.А., Oleshkevich D.O., Tsirulnikova O.M., Timanovsky A.S., Sharov A.N., Karpov D.V., Tveritnev P.N., Subbotin A.V., Pavlov A.G. The launch of the upper extremity transplantation program: clinical cases and key aspects of organizing work in a new area of clinical transplantology. Russian Journal of Transplantology and Artificial Organs. 2026;28(1):8-16. (In Russ.) https://doi.org/10.15825/1995-1191-2026-1-8-16

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ISSN 1995-1191 (Print)