Epidemiology of malignant tumors in kidney transplant recipients (a literature review)
https://doi.org/10.15825/1995-1191-2026-2-31-38
Abstract
Kidney transplant recipients face a significantly higher risk of developing malignant tumors. For certain tumor types, incidence rates are hundreds of times higher than in the non-transplant population. Overall cancer incidence and patterns vary significantly across countries, reflecting geographically specific risk factors. This literature review examines the epidemiological characteristics of post-transplant malignancies occurring in kidney transplant recipients worldwide.
About the Authors
R. N. Trushkin
Moscow Clinical Research Center – Hospital No. 52
Russian Federation
Russian Federation
Moscow
A. A. Sokolov
Central Clinical Hospital with Outpatient Clinic
Russian Federation
Russian Federation
Alexander A. Sokolov.
15, Marshala Timoshenko str., Moscow, 121359
Phone: (985) 492-35-77
S. A. Sokolov
Moscow Clinical Research Center – Hospital No. 52
Russian Federation
Russian Federation
Moscow
T. K. Isaev
Moscow Clinical Research Center – Hospital No. 52
Russian Federation
Russian Federation
Moscow
A. M. Isaeva
Central Clinical Hospital with Outpatient Clinic
Russian Federation
Russian Federation
Moscow
References
1. D’Arcy ME, Castenson D, Lynch CF, Kahn AR, Morton LM, Shiels MS et al. Risk of Rare Cancers Among Solid Organ Transplant Recipients. J Natl Cancer Inst. 2021 Feb 1; 113 (2): 199–207. doi: 10.1093/jnci/djaa078. PMID: 32462187; PMCID: PMC7850530.
2. Engels EA, Pfeiffer RM, Fraumeni JF Jr, Kasiske BL, Israni AK, Snyder JJ et al. Spectrum of cancer risk among US solid organ transplant recipients. JAMA. 2011 Nov 2; 306 (17): 1891–1901. doi: 10.1001/jama.2011.1592. PMID: 22045767; PMCID: PMC3310893.
3. Pyrża M, Małyszko J, Głogowski T, Wieliczko M, Żebrowski P, Małyszko J. Kidney Transplant Recipients Have Higher Malignancy Prevalence Than Hemodialyzed Patients. Transplant Proc. 2022 May; 54 (4): 972– 975. doi: 10.1016/j.transproceed.2022.01.018. Epub 2022 Mar 10. PMID: 35282885.
4. Friman TK, Jäämaa‑Holmberg S, Åberg F, Helanterä I, Halme M, Pentikäinen MO et al. Cancer risk and mortality after solid organ transplantation: A population-based 30-year cohort study in Finland. Int J Cancer. 2022 Jun 1; 150 (11): 1779–1791. doi: 10.1002/ijc.33934. Epub 2022 Feb 3. PMID: 35041762; PMCID: PMC9306582.
5. Benoni H, Eloranta S, Dahle DO, Svensson MHS, Nordin A, Carstens J et al. Relative and absolute cancer risks among Nordic kidney transplant recipients-a population-based study. Transpl Int. 2020 Dec; 33 (12): 1700–1710. doi: 10.1111/tri.13734. Epub 2020 Sep 25. PMID: 32896035; PMCID: PMC7756726.
6. Re Sartò GV, Alfieri C, Cosmai L, Brigati E, Campise M, Regalia A et al. Post-Kidney Transplant Cancer: A Real-World Retrospective Analysis From a Single Italian Center. Transpl Int. 2024 Aug 20; 37: 13220. doi: 10.3389/ti.2024.13220. PMID: 39228659; PMCID: PMC11368674.
7. Wimmer CD, Rentsch M, Crispin A, Illner WD, Arbogast H, Graeb C et al. The janus face of immunosuppression – de novo malignancy after renal transplantation: the experience of the Transplantation Center Munich. Kidney Int. 2007 Jun; 71 (12): 1271–1278. doi: 10.1038/sj.ki.5002154. Epub 2007 Feb 28. PMID: 17332737.
8. Apel H, Walschburger‑Zorn K, Häberle L, Wach S, Engehausen DG, Wullich B. De novo malignancies in renal transplant recipients: experience at a single center with 1882 transplant patients over 39 yr. Clin Transplant. 2013 Jan-Feb; 27 (1): E30–E36. doi: 10.1111/ctr.12050. Epub 2012 Dec 27. PMID: 23278453.
9. Ciesielski W, Frąk W, Gmitrzuk J, Kuczyński P, Klimczak T, Durczyński A et al. The assesement of the long-term effects of kidney transplantation, including the incidence of malignant tumors, in recipients operated on between 2006 and 2015 – a cohort study and literature review. Pol Przegl Chir. 2025 Jan 22; 97 (2): 1–9. doi: 10.5604/01.3001.0054.9677. PMID: 40247787.
10. Rossetto A, Tulissi P, De Marchi F, Gropuzzo M, Vallone C, Adani GL et al. De novo Solid Tumors After Kidney Transplantation: Is It Time for a Patient-Tailored Risk Assessment? Experience From a Single Center. Transplant Proc. 2015 Sep; 47 (7): 2116–2120. doi: 10.1016/j.transproceed.2015.01.029. PMID: 26361657.
11. Mazzucotelli V, Piselli P, Verdirosi D, Cimaglia C, Cancarini G, Serraino D et al. De novo cancer in patients on dialysis and after renal transplantation: north-western Italy, 1997–2012. J Nephrol. 2017 Dec; 30 (6): 851–857. doi: 10.1007/s40620-017-0385-y. Epub 2017 Mar 19. PMID: 28317077.
12. Gioco R, Corona D, Agodi A, Privitera F, Barchitta M, Giaquinta A et al. De novo Cancer Incidence and Prognosis After Kidney Transplantation: A Single Center Analysis. Transplant Proc. 2019 Nov; 51 (9): 2927– 2930. doi: 10.1016/j.transproceed.2019.04.096. Epub 2019 Oct 10. PMID: 31607617.
13. Piselli P, Serraino D, Cimaglia C, Furian L, Biancone L, Busnach G et al. Variation in Post-Transplant Cancer Incidence among Italian Kidney Transplant Recipients over a 25-Year Period. Cancers (Basel). 2023 Feb 20; 15 (4): 1347. doi: 10.3390/cancers15041347. PMID: 36831688; PMCID: PMC9954633.
14. Collett D, Mumford L, Banner NR, Neuberger J, Watson C. Comparison of the incidence of malignancy in recipients of different types of organ: a UK Registry audit. Am J Transplant. 2010 Aug; 10 (8): 1889–1896. doi: 10.1111/j.1600-6143.2010.03181.x. PMID: 20659094.
15. O’Neill JP, Sexton DJ, O’Leary E, O’Kelly P, Murray S, Deady S et al. Post-transplant malignancy in solid organ transplant recipients in Ireland, The Irish Transplant Cancer Group. Clin Transplant. 2019 Oct; 33 (10): e13669. doi: 10.1111/ctr.13669. Epub 2019 Sep 30. PMID: 31310037.
16. Conlon E, Fitzgerald C, Hintze J, Elhassan EAE, Sexton DJ, O’Leary E et al. High frequency and mortality of head and neck malignancy in organ transplant recipients in Ireland – A national cohort study. Am J Otolaryngol. 2023 Jul-Aug; 44 (4): 103827. doi: 10.1016/j.amjo-to.2023.103827. Epub 2023 Mar 9. PMID: 36933332.
17. Zavos G, Moris D, Kostakis ID, Vernadakis S, Bokos J, Zavvos V et al. De novo Visceral Malignancies in Renal Transplant Recipients: A Single Center Experience of 2054 Recipients for More Than 30 Years. Exp Clin Transplant. 2015 Aug; 13 (4): 313–318. PMID: 26295181.
18. Bašić‑Jukić N, Borlinić T, Tešanović D, Mokos I, Krešimir Lukić I, Bukvić Mokos Z. Risk factors for non-melanoma skin cancer development in renal transplant recipients: a 40 year retrospective study in Croatia. Croat Med J. 2022 Apr 30; 63 (2): 148–155. doi: 10.3325/cmj.2022.63.148. PMID: 35505648; PMCID: PMC9086819.
19. Cheung CY, Lam MF, Chu KH, Chow KM, Tsang KY, Yuen SK et al. Malignancies after kidney transplantation: Hong Kong renal registry. Am J Transplant. 2012 Nov; 12 (11): 3039–3046. doi: 10.1111/j.1600-6143.2012.04209.x. Epub 2012 Aug 6. PMID: 22883513.
20. Wu MJ, Lian JD, Yang CR, Cheng CH, Chen CH, Lee WC et al. High cumulative incidence of urinary tract transitional cell carcinoma after kidney transplantation in Taiwan. Am J Kidney Dis. 2004 Jun; 43 (6): 1091–1097. doi: 10.1053/j.ajkd.2004.03.016. PMID: 15168390.
21. Feng WW, Wang TN, Chen HC, Ho JC, Ko YC. Malignancies after renal transplantation in southern Taiwan: experience in one centre. BJU Int. 2007 Apr; 99 (4): 825–829. doi: 10.1111/j.1464-410X.2006.06645.x. Epub 2006 Nov 28. PMID: 17155978.
22. Yeh CC, Khan A, Muo CH, Yang HR, Li PC, Chang CH et al. De novo Malignancy After Heart, Kidney, and Liver Transplant: A Nationwide Study in Taiwan. Exp Clin Transplant. 2020 Apr; 18 (2): 224–233. doi: 10.6002/ect.2019.0210. Epub 2020 Mar 4. PMID: 32133940.
23. Li XB, Xing NZ, Wang Y, Hu XP, Yin H, Zhang XD. Transitional cell carcinoma in renal transplant recipients: a single center experience. Int J Urol. 2008 Jan; 15 (1): 53–57. doi: 10.1111/j.1442-2042.2007.01932.x. PMID: 18184173.
24. Wu B, Wang K, Mo CB, Shen ZY. De novo malignancies in renal transplant recipients: experience at a single center in China. Int J Clin Exp Med. 2015 Feb 15; 8 (2): 2911–2916. PMID: 25932254; PMCID: PMC4402901.
25. Sun Q, Li X, Cheng D, He Q, Chen J, Ji S, Liu Z. Special malignancy pattern in Chinese renal transplantation recipients: a single center experience and literature review. Asian Pac J Cancer Prev. 2011; 12 (12): 3347–3351. PMID: 22471478.
26. Zhang J, Ma L, Xie Z, Guo Y, Sun W, Zhang L et al. Epidemiology of post-transplant malignancy in Chinese renal transplant recipients: a single-center experience and literature review. Med Oncol. 2014 Jul; 31 (7): 32. doi: 10.1007/s12032-014-0032-6. Epub 2014 Jun 8. PMID: 24908063.
27. Ho CJ, Huang YH, Hsieh TY, Yang MH, Wang SC, Chen WJ et al. Native Kidney Hydronephrosis Is Associated with Upper Urinary Tract Urothelial Carcinoma in Post-Kidney Transplantation Patients. J Clin Med. 2021 Sep 28; 10 (19): 4474. doi: 10.3390/jcm10194474. PMID: 34640492; PMCID: PMC8509333.
28. Ho CJ, Huang YH, Hsieh TY, Yang MH, Wang SC, Chen WJ et al. New Hydronephrosis in the Native Kidney Is Associated with the Development of De novo Urinary Bladder Urothelial Carcinoma in Patients with Post-Kidney Transplantation. Healthcare (Basel). 2023 Apr 23; 11 (9): 1209. doi: 10.3390/healthcare11091209. PMID: 37174750; PMCID: PMC10178461.
29. Laowalert S, Naitook N, Boonnim K, Prungrit U, Aekkachaipitak N, Lamjantuek P et al. Report on post-transplantation cancer in southeast Asia from the Thai kidney transplantation cohort. Sci Rep. 2024 Aug 30; 14 (1): 20154. doi: 10.1038/s41598-024-71041-x. PMID: 39215076; PMCID: PMC11364626.
30. Srisuwarn P, Sutharattanapong N, Disthabanchong S, Kantachuvesiri S, Kitiyakara C, Phakdeekitcharoen B et al. Incidence of De novo Post-Transplant Malignancies in Thai Adult Kidney Transplant Recipients: A Single-Center, Population-Controlled, Retrospective Cohort Study at the Highest Volume Kidney Transplant Center in Thailand. Transpl Int. 2024 Feb 26; 37: 11614. doi: 10.3389/ti.2024.11614. PMID: 38468637; PMCID: PMC10926888.
31. Ju MK, Joo DJ, Kim SJ, Huh KH, Kim MS, Jeon KO et al. Chronologically different incidences of post-transplant malignancies in renal transplant recipients: single center experience. Transpl Int. 2009 Jun; 22 (6): 644–653. doi: 10.1111/j.1432-2277.2009.00846.x. Epub 2009 Feb 10. PMID: 19220824.
32. Hwang JK, Moon IS, Kim JI. Malignancies after kidney transplantation: a 40-year single-center experience in Korea. Transpl Int. 2011 Jul; 24 (7): 716–721. doi: 10.1111/j.1432-2277.2011.01270.x. Epub 2011 May 16. PMID: 21575081.
33. Park B, Yoon J, Choi D, Kim HJ, Jung YK, Kwon OJ et al. De novo cancer incidence after kidney and liver transplantation: Results from a nationwide population based data. Sci Rep. 2019 Nov 20; 9 (1): 17202. doi: 10.1038/s41598-019-53163-9. PMID: 31748582; PMCID: PMC6868238.
34. Jeong S, Lee HS, Kong SG, Kim DJ, Lee S, Park MJ et al. Incidence of malignancy and related mortality after kidney transplantation: a nationwide, population-based cohort study in Korea. Sci Rep. 2020 Dec 8; 10 (1): 21398. doi: 10.1038/s41598-020-78283-5. PMID: 33293655; PMCID: PMC7722878.
35. Teo SH, Lee KG, Lim GH, Koo SX, Ramirez ME, Chow KY et al. Incidence, risk factors and outcomes of malignancies after kidney transplantation in Singapore: a 12-year experience. Singapore Med J. 2019 May; 60 (5): 253–259. doi: 10.11622/smedj.2018122. Epub 2018 Oct 10. PMID: 30311626; PMCID: PMC6535454.
36. Imamura R, Nakazawa S, Yamanaka K, Kakuta Y, Tsutahara K, Taniguchi A et al. Cumulative cancer incidence and mortality after kidney transplantation in Japan: A long-term multicenter cohort study. Cancer Med. 2021 Apr; 10 (7): 2205–2215. doi: 10.1002/cam4.3636. Epub 2020 Dec 13. PMID: 33314709; PMCID: PMC7982608.
37. Kanno S, Noda T, Myojin T, Nishioka Y, Kubo S, Eriguchi M et al. Incidence and risk of cancer emergence among patients post-kidney transplantation in Japan. Clin Exp Nephrol. 2025 Aug 27. doi: 10.1007/s10157-025-02748-y. Epub ahead of print. PMID: 40864337.
38. Villeneuve PJ, Schaubel DE, Fenton SS, Shepherd FA, Jiang Y, Mao Y. Cancer incidence among Canadian kidney transplant recipients. Am J Transplant. 2007 Apr; 7 (4): 941–948. doi: 10.1111/j.1600-6143.2007.01736.x. Epub 2007 Feb 28. PMID: 17331115.
39. Sapir‑Pichhadze R, Laprise C, Beauchamp ME, Kaouache M, Zhang X, Della Vecchia A et al. Immunosuppression and cancer risk in kidney transplant recipients: A retrospective cohort study. Int J Cancer. 2024 Jun 15; 154 (12): 2043–2053. doi: 10.1002/ijc.34875. Epub 2024 Feb 12. PMID: 38345158.
40. Sampaio MS, Cho YW, Qazi Y, Bunnapradist S, Hutchinson IV, Shah T. Posttransplant malignancies in solid organ adult recipients: an analysis of the U.S. National Transplant Database. Transplantation. 2012 Nov 27; 94 (10): 990–998. doi: 10.1097/TP.0b013e318270bc7b. PMID: 23085553.
41. Blosser CD, Haber G, Engels EA. Changes in cancer incidence and outcomes among kidney transplant recipients in the United States over a thirty-year period. Kidney Int. 2021 Jun; 99 (6): 1430–1438. doi: 10.1016/j.kint.2020.10.018. Epub 2020 Nov 5. PMID: 33159960; PMCID: PMC8096865.
42. Tao J, Shing JZ, Yu KJ, Kreimer AR, Hsieh MC, Pawlish KS et al. Spectrum of cancer risk in Asian American and Pacific Islander solid organ transplant recipients. J Natl Cancer Inst. 2025 Jul 1; 117 (7): 1456–1464. doi: 10.1093/jnci/djaf069. PMID: 40112042; PMCID: PMC12229455.
43. Sargen MR, Cahoon EK, Yu KJ, Madeleine MM, Zeng Y, Rees JR et al. Spectrum of Nonkeratinocyte Skin Cancer Risk Among Solid Organ Transplant Recipients in the US. JAMA Dermatol. 2022 Apr 1; 158 (4): 414–425. doi: 10.1001/jamadermatol.2022.0036. PMID: 35262623; PMCID: PMC8908231.
44. Sargen MR, Cahoon EK, Lynch CF, Tucker MA, Goldstein AM, Engels EA. Sebaceous Carcinoma Incidence and Survival Among Solid Organ Transplant Recipients in the United States, 1987–2017. JAMA Dermatol. 2020 Dec 1; 156 (12): 1307–1314. doi: 10.1001/jamadermatol.2020.3111. PMID: 33146669; PMCID: PMC7643042.
45. Leon‑Rodriguez E, Armengol‑Alonso A, Rivera‑Franco MM, Alberú‑Gómez J, Merchan‑Alvear P. Malignancies after renal transplantation: experience of a Mexican referral center. Clin Transl Oncol. 2020 Oct; 22 (10): 1796–1801. doi: 10.1007/s12094-020-02318-6. Epub 2020 Feb 19. PMID: 32076993.
46. Malagón‑Liceaga A, Bermúdez‑Rodríguez SP, Romero-Aguila JA, Carolina LF, Palafox‑Romo R, Díaz‑Sánchez VM et al. Skin cancer incidence in Mexican renal transplant recipients: a cohort over 56 years. Int J Dermatol. 2024 Nov; 63 (11): e315–e321. doi: 10.1111/ijd.17332. Epub 2024 Jun 21. PMID: 39425592.
47. Vajdic CM, McDonald SP, McCredie MR, van Leeuwen MT, Stewart JH, Law M et al. Cancer incidence before and after kidney transplantation. JAMA. 2006 Dec 20; 296 (23): 2823–2831. doi: 10.1001/jama.296.23.2823. PMID: 17179459.
Review
For citations:
Trushkin R.N., Sokolov A.A., Sokolov S.A., Isaev T.K., Isaeva A.M. Epidemiology of malignant tumors in kidney transplant recipients (a literature review). Russian Journal of Transplantology and Artificial Organs. 2026;28(2):31-38. (In Russ.) https://doi.org/10.15825/1995-1191-2026-2-31-38
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