Advances in overcoming immunological and physiological barriers in xenotransplantation
D. A. Velikiy,
Yu. B. Basok,
N. V. Grudinin,
O. E. Gichkun,
A. P. Trashkov,
A. V. Varlachev,
O. P. Shevchenko https://doi.org/10.15825/1995-1191-2025-4-133-137
Abstract
The growing number of patients with severe organ diseases, along with the increasing demand for retransplantations, has intensified the global shortage of donor organs – the primary limitation to expanding transplant programs. Advances in genetic engineering and cell therapy technologies are opening new opportunities for the use of animal organs in human transplantation. Enhancing the effi cacy and safety of this approach requires overcoming signifi cant immunological and physiological barriers inherent in xenotransplantation. This review summarizes recent progress in genetic modification of donor animals, use of cell-based therapy in xenotransplantation, and prospects for clinical application.
About the Authors
D. A. Velikiy
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
Dmitriy Velikiy
Address: 1, Shchukinskaya str., Moscow, 123182
Yu. B. Basok
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
Moscow
N. V. Grudinin
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
Moscow
O. E. Gichkun
Shumakov National Medical Research Center of Transplantology and Artificial Organs;
Sechenov University
Russian Federation
Russian Federation
Moscow
A. P. Trashkov
Kurchatov Institute
Russian Federation
Russian Federation
Moscow
A. V. Varlachev
Kurchatov Institute
Russian Federation
Russian Federation
Moscow
O. P. Shevchenko
Shumakov National Medical Research Center of Transplantology and Artificial Organs;
Sechenov University
Russian Federation
Russian Federation
Moscow
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Review
For citations:
Velikiy D.A., Basok Yu.B., Grudinin N.V., Gichkun O.E., Trashkov A.P., Varlachev A.V., Shevchenko O.P. Advances in overcoming immunological and physiological barriers in xenotransplantation. Russian Journal of Transplantology and Artificial Organs. 2025;27(4):133-137. (In Russ.) https://doi.org/10.15825/1995-1191-2025-4-133-137
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