Hybrid hemodynamic modeling for optimization of mechanical circulatory support systems
https://doi.org/10.15825/1995-1191-2025-4-103-109
Abstract
Objective: to propose and justify approaches for improving the classical hemodynamic test bench, widely used to model the integration of mechanical circulatory support (MCS) systems.
Materials and methods. The hemodynamic test bench consisted of multiple containers and resistors simulating systemic and pulmonary circulation, enabling the study of physiological conditions in heart failure (HF). The setup also included an auxiliary circulatory support pump and a pulsatile flow generator.
Results. A mathematical model of the cardiovascular system was developed, capable of reproducing physiological states under conditions of pump-assisted circulation and pulsatile flow. Comparative evaluation of experimental and modeling results highlighted the advantages and limitations of different modeling methods.
Conclusion. Based on these findings, strategies for further development of the hemodynamic test bench, aimed at enhancing its ability to simulate the impact of mechanical circulatory support on key hemodynamic parameters, were formulated and justified.
About the Authors
A. I. Syrbu
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
Arseniy Syrbu
Address: 1, Shchukinskaya str., Moscow, 123182
A. O. Shevchenko
Shumakov National Medical Research Center of Transplantology and Artificial Organs;
Sechenov University
Russian Federation
Russian Federation
Moscow
N. V. Grudinin
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
Moscow
A. S. Buchnev
Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
Moscow
References
1. Gautier SV. Priority areas of scientific research in the field of transplantology and artificial organs. Russian Journal of Transplantology and Artificial Organs. (In Russ.). 2025; 27 (1): 6–7.
2. Cameli M, Pastore MC, Campora A, Lisi M, Mandoli GE. Donor shortage in heart transplantation: How can we overcome this challenge? Front Cardiovasc Med. 2022 Oct 17; 9: 1001002. doi: 10.3389/fcvm.2022.1001002.
3. Kyriakopoulos CP, Kapelios CJ, Stauder EL, Taleb I, Hamouche R, Sideris K et al. LVAD as a bridge to remission from advanced heart failure: current data and opportunities for improvement. J Clin Med. 2022 Jun 20; 11 (12): 3542. doi: 10.3390/jcm11123542.
4. Itkin GP, Bychnev AS, Kuleshov AP, Drobyshev AA. Haemodynamic evaluation of the new pulsatile-flow generation method in vitro. Int J Artif Organs. 2020 Mar; 43 (3): 157–164. doi: 10.1177/0391398819879939.
5. Buchnev AS, Kuleshov AP, Esipova OYu, Drobyshev AA, Grudinin NV. Hemodynamic evaluation of pulsatileflow generating device in left ventricular assist devices. Russian Journal of Transplantology and Artificial Organs. 2023; 25 (1): 106–112. (In Russ.). https://doi.org/10.15825/1995-1191-2023-1-106-112.
6. Itkin GР. Ventricle assist device: past, present, and future nonpulsatile pumps. Russian Journal of Transplantology and Artificial Organs. 2009; 11 (3): 81–87. (In Russ.). https://doi.org/10.15825/1995-1191-2009-3-81-87.
7. Fresiello L, Muthiah K, Goetschalckx K, Hayward C, Rocchi M, Bezy M et al. Initial clinical validation of a hybrid in silico–in vitro cardiorespiratory simulator for comprehensive testing of mechanical circulatory support systems. Front Physiol. 2022 Oct 13; 13: 967449. doi: 10.3389/fphys.2022.967449.
8. Pugovkin AA, Markov AG, Selishchev SV, Korn L, Walter M, Leonhardt S et al. Advances in hemodynamic analysis in cardiovascular diseases investigation of energetic characteristics of adult and pediatric sputnik left ventricular assist devices during mock circulation support. Cardiol Res Pract. 2019 Nov 15; 2019: 4593174. doi: 10.1155/2019/4593174.
9. Itkin GP, Nosov MS, Kuleshov AP, Drobyshev AA, Buchnev AS. Blood flow control device in implantable extracorporeal circulation systems. Patent for a utility model. No. RU 201911 U1. Patent holder: Shumakov National Medical Research Center of Transplantology and Artificial Organs. 2020.
10. Syrbu AI, Itkin GP, Kuleshov AP, Gaidai NA. A mathematical model of neurohumoral regulation of the circulatory system. Biomedical Engineering. 2021; 55 (4): 41–44.
11. Itkin GP, Syrbu AI, Kyleshov AP, Buchnev AS, Drobyshev AA. Evaluation of the efficiency of a new pulsatile flow-generating circulatory-assist system in rotary blood pumps. Research on a mathematical model. Russian Journal of Transplantology and Artificial Organs. 2021; 23 (4): 73–78. (In Russ.). https://doi.org/10.15825/1995-1191-2021-4-73-78.
12. Cappon F, Wu T, Papaioannou T, Du X, Hsu PL, Khir AW. Mock circulatory loops used for testing cardiac assist devices: A review of computational and experimental models. Int J Artif Organs. 2021 Nov; 44 (11): 793–806. doi: 10.1177/03913988211045405.
13. Gregory SD, Pauls JP, Wu EL, Stephens A, Steinseifer U, Tansley G, Fraser JF. An advanced mock circulation loop for in vitro cardiovascular device evaluation. Artif organs. 2020 Jun; 44 (6): E238–E250. doi: 10.1111/aor.13636.
14. Rapp ES, Pawar SR, Longoria RG. Hybrid mock circulatory loop simulation of extreme cardiac events. IEEE Trans Biomed Eng. 2022 Sep; 69 (9): 2883–2892. doi: 10.1109/TBME.2022.3156963.
15. Ochsner G, Amacher R, Amstutz A, Plass A, Daners MS, Tevaearai H et al. A novel interface for hybrid mock circulations to evaluate ventricular assist devices. IEEE Trans Biomed Eng. 2013 Feb; 60 (2): 507–516. doi: 10.1109/TBME.2012.2230000. Epub 2012 Nov 27.
16. Petrou A, Granegger M, Meboldt M, Daners MS. A versatile hybrid mock circulation for hydraulic investigations of active and passive cardiovascular implants. ASAIO J. 2019 Jul; 65 (5): 495–502. doi: 10.1097/MAT.0000000000000851.
17. Ślęzak M, Kopernik M, Szawiraacz K, Milewski G. Assessment of blood flow parameters in a hybrid-digital model of the cardiovascular system applying recurrent neural networks. Biomedical Signal Processing and Control. 2024 Dec; 98: 106680. https://doi.org/10.1016/j.bspc.2024.106680.
18. Syrbu AI, Itkin GP. Optimization of the parameters of ventricular assist devices using computerized mathematical modeling of the cardiovascular system. Biomedical Engineering. 2022; 56 (2): 23–26.
19. Jansen‐Park SH, Mahmood MN, Müller I, Turnhoff LK, Schmitz‐Rode T, Steinseifer U, Sonntag SJ. Effects of interaction between ventricular assist device assistance and autoregulated mock circulation including Frank– Starling mechanism and baroreflex. Artif Organs. 2016 Oct; 40 (10): 981–991. doi: 10.1111/aor.12635.
Review
For citations:
Syrbu A.I., Shevchenko A.O., Grudinin N.V., Buchnev A.S. Hybrid hemodynamic modeling for optimization of mechanical circulatory support systems. Russian Journal of Transplantology and Artificial Organs. 2025;27(4):103-109. (In Russ.) https://doi.org/10.15825/1995-1191-2025-4-103-109
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